(SeMet) is a major form of selenium compounds in foods. The article by Arakawa et al. demonstrated that ear thickness
was increased by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) to the
ear, and SeMet significantly suppressed ear thickness in mice. SeMet inhibited
epidermal hyperplasia and dense infiltration of inflammatory cells. Serum total
immunoglobulin (Ig) E levels were suppressed by SeMet. Interleukin (IL) 4
expression in the ear and superficial parotid lymph node was inhibited by
SeMet. These results demonstrated that SeMet suppresses atopic dermatitis-like
skin lesions and inhibits the expression of total IgE and IL-4.