The Review of Laser Engineering
Online ISSN : 1349-6603
Print ISSN : 0387-0200
ISSN-L : 0387-0200
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Volume 32, Issue 10
Displaying 1-9 of 9 articles from this issue
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Topical Papers on Photoacoustic Biometry and Medical Diagnoses
Topical Paper
Laser Review
  • Photoacoustic Biometry and Medical Diagnoses -Preface to Topical Papers-
    Shunichi SATO, Mutsuo YAMAZAKI, Minoru OBARA
    2004 Volume 32 Issue 10 Pages 622-626
    Published: October 15, 2004
    Released on J-STAGE: September 19, 2009
    DOIhttps://doi.org/10.2184/lsj.32.622
    JOURNAL FREE ACCESS
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    Principle and medical applications of photoacoustic diagnosis are reviewed. Photoacoustic diagnosis involves both advantages of optical and ultrasonic measurements, by which deep-located tissue can be diagnosed or imaged with a high spatial resolution. Applications to diagnosis of pigmented skin diseases, real-time monitoring of laser cyclophotocoagulation, detection of early cancer, functional brain imaging are described.
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  • Photoacoustic Glucose Monitoring
    Kazuhiro ITSUMI, Shoichi KANAYAMA
    2004 Volume 32 Issue 10 Pages 627-630
    Published: October 15, 2004
    Released on J-STAGE: September 19, 2009
    DOIhttps://doi.org/10.2184/lsj.32.627
    JOURNAL FREE ACCESS
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    Photoacoustic spectroscopy is an alternative technique for noninvasive glucose monitoring of diabetic patients. The incident near-infrared light penetrates a few millimeters into human tissue and generates an acoustic wave that is derived from the optical absorption. The photoacoustic signal is detected by a piezoelectric transducer, and the glucose concentration in human tissue is estimated from the magnitude of the signal. Several studies have been carried out to eliminate the numerous optically interfering components in human blood and tissue. In this paper, in vivo and in vitro photoacoustic measurements of glucose are reviewed and a highly sensitive photoacoustic sensor that uses a Pb(Zn1/3Nb2/3)O3-PbTiO3 (PZNT91/9) single crystal with an extremely large piezoelectric constant g33 is described.
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  • Applications of Photoacoustic Microscopy and Imaging to Biological and Medical Science and Technology
    Tsutomu HOSHIMIYA
    2004 Volume 32 Issue 10 Pages 631-635
    Published: October 15, 2004
    Released on J-STAGE: September 19, 2009
    DOIhttps://doi.org/10.2184/lsj.32.631
    JOURNAL FREE ACCESS
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    In this article, the basic principle of photoacoustic microscope (PAM) and imaging was introduced paying the special attention to its detection schemes. The experimental apparatus and applications of PAM were reviewed. Depth profiling using PAM in the nondestructive inspection of semiconductor device was discussed. The principle of spectroscopic analysis method by integration over PAM image measured with respect chemical reagent concentraion or pollen number was also discussed. Furthermore, photoacoustic imaging technique including photoacoustic tomography applied to biological imaging was reviewed.
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  • Photoacoustic Diagnoses in Traumatology
    Mutsuo YAMAZAKI, Shunichi SATO, Daizo SAITO, Minoru OBARA
    2004 Volume 32 Issue 10 Pages 636-639
    Published: October 15, 2004
    Released on J-STAGE: September 19, 2009
    DOIhttps://doi.org/10.2184/lsj.32.636
    JOURNAL FREE ACCESS
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    In this paper, we present the application of photoacoustic measurement to burn depth estimation and adhesion monitoring of skin grafts. In both applications, photoacoustic signals originated from the bloods are measured with a piezoelectric transducer put on the skin surface. Experiments using rat burn model showed that quantitative depth information of burn injury can be obtained. The technique can also be used to detect neovascularity in the grafted skin tissue; neovascularity is an indication of grafted tissue adhesion.
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Laser Original
  • Development of A Method Using Photoacoustic Measurement for Evaluation of the Viscoelasticity of Articular Cartilage in Regenerative Medicine
    Miya ISHIHARA, Masato SATO, Shunichi SATO, Toshiyuki KIKUCHI, Masayuki ...
    2004 Volume 32 Issue 10 Pages 640-644
    Published: October 15, 2004
    Released on J-STAGE: September 19, 2009
    DOIhttps://doi.org/10.2184/lsj.32.640
    JOURNAL FREE ACCESS
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    We propose a method for noninvasive viscoelastic characterization of biological tissue using photoacoustic measurement. The relaxation time (η/G , η being viscosity and G being elasticity) of laser-induced photoacoustic signals agreed with intrinsic relaxation parameters measured using a conventional rheometer with a correlation coefficient over 0.99 when the density of a gelatin model was changed in the range of 5-25 % as samples. We also applied this measurement method to tissue-engineered cartilage cultured for various periods (up to 12 weeks). Longer culture period resulted in greater viscoelasticity, which is equivalent to shorter relaxation time. The correlation between relaxation times of the photoacoustic signals and biochemical characteristics of the cultured cartilage revealed that the cartilage acquired viscoelasticity during the process of formation of an extracellular matrix such as collagen. This study demonstrated the usefulness of photoacoustic measurement for evaluating the viscoelastic properties of actual cultured cartilage using a tissue-engineering technique.
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  • Development of A Small-Diameter Photoacoustic Probe for Early Cancer Diagnosis
    Hiroharu MUKAIDA, Shunichi SATO, Hiroshi ASHIDA, Tsunenori ARAI
    2004 Volume 32 Issue 10 Pages 645-647
    Published: October 15, 2004
    Released on J-STAGE: September 19, 2009
    DOIhttps://doi.org/10.2184/lsj.32.645
    JOURNAL FREE ACCESS
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    We have proposed a method for photoacoustic diagnosis of deep-located early cancer in which a tumor-localizing photosensitizer is used to enhance the absorption contrast of the tumor. A photoacoustic probe of 3 mm in diameter was developed to apply this method to diagnosis of cancer in digestive organs. Its design and characteristics of detection for a pancreatic cancer model are described.
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Regular Paper
Laser Original
  • Real Time Measurement of A Surface Displacement with Two Laser Beams
    Tomotaka KOZUKI, Tomomi HONDA, Tetsuma SAKURAI, Masahiro UEDA
    2004 Volume 32 Issue 10 Pages 648-652
    Published: October 15, 2004
    Released on J-STAGE: September 19, 2009
    DOIhttps://doi.org/10.2184/lsj.32.648
    JOURNAL FREE ACCESS
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    An optical method for measuring surface displacement in real time has been proposed by means of a system composed of two laser beams, and is discussed analytically using paraxial optics. The normalized light intensity defined by both the lights, I=(I1-I2) / (I1+I2), was expressed by I = -2(f1-f0)2 (1/q) Δf0, where f1 and f2 are the focal lengths of the first (objective) and second (focusing) lenses, q a distance between the pinhole and the focal point of the second lens for both laser beams, and Δf0 surface displacement. The above analytical result has been roughly verified by preliminary experiment, though there were differences in absolute intensity between the experimental and the analytical results. The spatial resolution of this method was expected to be about 2 μm from these analytical and experimental results.
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Technical Note
Laser Flash
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