In some former reports, the irradiation of laser improved the dentin hypersensitivity in the clinical situations. However, the mechanism of the improvement has not fully been understood. The purpose of this study was to investigate the effects of the laser irradiation on the coagulation of a protein using a liver of Pig. The liver surface was laser-irradiated as a following conditions; Scan speed of the irradiation: 4.7mm/sec, Area of the irradiation: 5×10
-3cm
2, Output power: 280mW, Power density: 56W/cm
2, Repetition rate: 40 Hz, Pulse duration: 650μsec. The photograph images showed that the irradiation of CO
2 laser using this condition coagulated the protein without causing thermal damage to the peripheral tissue. Hence, we suggest that the CO
2 laser irradiation of this parameter is effective for the treatment of the dentin hypersensitivity in the clinical situations.
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