Practica Oto-Rhino-Laryngologica

Hemangioma of the Parotid Gland in an Infancy Treated by X-Ray Irradiation

H. TAMURA, K. KIMURA, N. KAWAMOTO, T. KONO

1963 Volume 56 Issue 8 Pages 429-434
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.429

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We encountered on a case of 7 weeks female infant with a great tumor in the right parotid region.
It was revealed microscopically that this tumor was hemangioendothelioma. The tumor had remarkable regression after X-ray therapy.

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A Case Report of Lymphangioma in the Nasal Cavity

H. TAMURA, T. KONO, T. HIRAOKA

1963 Volume 56 Issue 8 Pages 435-437
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.435

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We removed surgically the tumor on the left side of nasal septum. The patient was 13 year-old boy. Microscopically this tumor was lymphangioma simplex.

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A case of agranulocytosis probably happened by Myosedan

S. KUSUYAMA, T. KIMURA

1963 Volume 56 Issue 8 Pages 437-441
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.437

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A case of agranulocytosis probably happened by Myosedan in 52 year-old male is reported here. He was getting three pills a day for two weeks. After that, the agranulocytosis and angina necroticans came out. His blood picture showed the remarkable decrease of the neutrophile granulocytes in number. The treatment were applied to him as far as possible, but unfortunately he died on the 16th day.

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An Interesting Case of the Palatal Cancer

H. TAMURA, T. YAMASHITA, S. UEDA, N. UEDA

1963 Volume 56 Issue 8 Pages 442-447
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.442

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A woman, aged 61, was found to have been affected with a large obsolete prolif erative ulcer involving the junction between the hard and soft palate causing of an artificial tooth since several years before. After observations for 2 years, the authors recognized squamous cell carcinoma arising from that ulcer.
A surprising effect was found with the treatment of Endoxan-Asta (B 518) to this case, for which clinical and patho-histologic investgiations were followed up to the clinical healing.

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Therapeutic Experiments with Trostin-M

-A newly developed hemostatica-

Y. WATABE, H. KOSAKADA

1963 Volume 56 Issue 8 Pages 448-453
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.448

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Forty two patients were treated with Trostin-M inj., and its hemostatic effects were studied.
Trostin-M was administered in the following three ways.
Each ampule contains 25mg of thromboplastin and 100mg of ε-aminocaproic acid, anitplasminic.
a) One or two ampules of Trostin-M were given prior to operation.
b) One or two ampules of Trostin-M dissolved in 100ml of 0.5% procain was given locally.
c) Local gauze tamponing soaked with Trostin-M.
Results
Markedly effective 6, Effective 30, Slightly effective 3, Ineffective 3.
Local administration showed marked hemostatic action.
No untoward reactions were observed in all cases.

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The Cllincal Application of Trilafon-Polaramin Tablets for Ménière's Disease

Y. TOMINAGA

1963 Volume 56 Issue 8 Pages 454-459
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.454

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Trilafon and Polaramine were concomitantly used on 31 patients with Ménière's disease or conditions exhibiting symptoms similar to Ménière's disease. The results were as follows:
1) The combined use of the prugs was markedly effective in 9 patients, effective in 11 patients, somewhat effective in 5 patients, and not effective in 6 patients.
2) Subjective symptoms such as nausea and vertigo were controlled or ameliorated comparatively early in the treatment, however, a long term therapy was required to control tinnitus and dysacousis.
3) The shorter the time interval between onset of the disease and inception of treatment, the better the results of the treatment.
4) Practically no untoward side effects were recognized with the dosage used in this study.
(This paper was presented at the 259th Meeting of the Japanese Society of Otorhinolaryngology held in Kyushu)

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Effects of DHSM and KM on Succinic Oxyolation System in the Cochlea of Guinea-pig

M. ODA

1963 Volume 56 Issue 8 Pages 460-466
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.460

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Effects of DHSM and KM on succinic oxyolation system in the cochlea were tested by a new technique, in which O₂ consumption was measured by adding staining material into the substrate and immediately after the measurement histochemical reactions were observed under the microscope.
This method made it possible that measurement of the O₂ Consumption and the histochemical staining can be performed simultaneously on a same tissue preparation.
It is difficult to determine by solely histochemical method that effects are caused whether by disturbances in succinic dehydrogenase system or those in cytochromoxydase, because there are inconsistency between amount of O₂ Consumption and the results of histochemical reaction.
By this new method, it was bound that disturbances elicited by KM were stronger than those of DHSM, particularly in the cytochromoxydase system. On the other hand, succinic dehydrogenase were affected to a same extent both by DHSM and KM.

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Studies on Experimental Mucosal Reaction of the Epipharynx

-Its Local and Generalized Effect

Kazuaki KITAHARA

1963 Volume 56 Issue 8 Pages 466-480
Published: 1963
Released on J-STAGE: October 14, 2011

DOIhttps://doi.org/10.5631/jibirin.56.466

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Studies of experimentally mucosal allergic reaction of the epipharynxwall, changes of local alkali phosphatase through the Shwartzman's phenomenon and effect of diphtheria toxin injection into epipharynxwall on general organs were carried out in rabbits for the purpose of clarifying the mechanism of “Epipharynx syndrome and symptom (Yamasaki).”
1) The Shwartzman's phenomenon on mucous membranes of the epipharynx;
14 albino male rabbits weighted about 2kg were divided into 2 groups. The first group (10 rabbits) were initially injected with 0.2cc of prodigiosus culture filtrates into both mucous membranes of the epipharynx and buccal mucous membranes, and then 24hours later were injected intravenously with 2cc of the same filtrates. The second group (4 rabbits) were done only the former proceedures as a control. The following results were obtained.
A severe hemorrhagic reaction was seen in all 10 rabbits of the first group and hyperemia was seen in 1. out of 4 rabbits of the control group at injected mucous membranes of the epipharynx, but no reactions were observed in both groups at injected buccal area.
Histological findings of the Shwartzman's reactions area of the epipharynx were remarkably similar to those noted in skin reaction. A severe hemorrhagic reaction with necrosis observed in submucous tissue was mainly due to rupture of the blood vessels below the surface and fibrinous thrombosis was frequently observed. Infiltrations of polynucleic leucocytes were preferably few.
2) Changes of local alkali phosphatase through the Shwartzman's phenomenon;
Immediately before the Shwartzman's reactive injection, adrenalin, pilocarpin or atropin was injected into one side of the epipharynx wall of each rabbit and then various degree of local skin reaction was able to be obtained. Male albino rabbits were dissected 6 hours after injection of the various vegetative posions and local alkali phosphatase in abdominal skins where the Shwartzman's phenomenon was seen, was measured after Gomori-Takamatsu's methode.
Local alkali phosphatase was appeared to be increased according as hemorrhagic reaction was marked to be stronger.
3) Effect of diphtheria toxin injection into mucous membranes of the epipharynx on general orgns.
On male albino rabbits injected with 0.5cc of diphtheria toxin (L. F, 85 unit) into mucous membranes of the epipharynx and dissected immediately after injection, histological observations of submaxillary glands, lungs, suprarenal bodies and kidneies were made.
As a control, same proceedures were done on rabbits dissected immediately and 3 hours after injection into subcutaneous tissue.
In cases injected into the epipharynx and dissected immediately after injection, histological changes were noted most remarkablly in contrast with cases injected into subcutaneous tissue and dissected immediately after injection, which were found few histological lesions.
In cases injected into subcutaneous tissue and dissected 3 hours after injections, these changes were moderate. Amongs observed organs, suprarenal bodies showed most marked hypertrophy and hemorrhagic reaction with necrosis in fascicular zone.
The Author presumes that mucous membranes of the epipharynx wall are very sensitive to local reaction such as the Shwartzman's phenomenon and mucosal reaction of the epipharynx is closely related with generalized effect.

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