Practica Oto-Rhino-Laryngologica
Online ISSN : 1884-4545
Print ISSN : 0032-6313
ISSN-L : 0032-6313
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Volume 85, Issue 6
Displaying 1-28 of 28 articles from this issue
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  • Voice Therapy
    [in Japanese]
    1992 Volume 85 Issue 6 Pages 847-849
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.847
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1992 Volume 85 Issue 6 Pages 849-852
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.849
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1992 Volume 85 Issue 6 Pages 853-856
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.853
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  • [title in Japanese]
    [in Japanese]
    1992 Volume 85 Issue 6 Pages 856-860
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.856
    JOURNAL FREE ACCESS
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  • Endoscopic Endonasal Surgery Using Nd-YAG Laser
    [in Japanese], [in Japanese]
    1992 Volume 85 Issue 6 Pages 862-863
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.862
    JOURNAL FREE ACCESS
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  • Hypoglossal Neurilemmoma Resected with Suboccipital C raniectomy; A Case Report
    Shigeru Hirano, Mitsuharu Nonomura, Hideyuki Fukushima
    1992 Volume 85 Issue 6 Pages 865-871
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.865
    JOURNAL FREE ACCESS
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    Neurilemmomas of the hypoglossal nerve are uncommon; our report is the 49th case in the world.
    A 55-year-old female was admitted to Kyoto University hospital for relief of pharyngeal discomfort. Paralysis and atrophy of the left side of the tongue and curtain's sign were noted. Computerized tomography showed tumor of the left parapharyngeal space extending to the intracranial region with destruction of the hypoglossal canal. Magnetic resonance imaging was useful in defining the extent of the tumor. One-stage suboccipital craniectomy was performed through an infratemporal fossa approach.
    Examination of the intracranial region by CT or MRI is necessary for the diagnosis of hypoglossal neurilemmoma of the parapharyngeal space.
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  • Mitochondrial Encephalopathy with Progressive Hearing Impairment; A Case Report
    Jin-ichi Shidara, Kimitaka Kaga
    1992 Volume 85 Issue 6 Pages 873-879
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.873
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    An 11-year-old female had complained of headache, eye pain, fever and vomiting at the age of 5 years. MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes) was diagnosed at the age of 7 years by muscle biopsy. She was referred to our department because of hearing impairment at 8 years of age.
    Our first examination disclosed weakness of the extremities, mental disturbance, and hearing impairment. The pure tone audiogram showed a hearing level of 46dB on the right and of 39dB on the left. Two year later, the hearing level was about 20dB higher bilateraly. Auditory brainstem responses showed no brainstem damage and hearing levels similar to the pure tone audiogram.
    Electrocochleograms and evoked otoacoustic emission tests suggested that hearing impairment was due to a cochlear disturbance.
    However, speech audiograms suggested that there might be an associated retrocochlear disturbance too.
    Vestibular function was not disturbed. MELAS is known to include degeneration of small arteries of the brain (mitochondrial angiopathy).
    In our patient, cochlear and retrocochlear disturbances seem to have been caused partially by disturbances secondary to degeneration of small arteries.
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  • Lermoyez's Syndrome; A Case Report
    Masutoshi Nishikawa, Keiko Nishikawa
    1992 Volume 85 Issue 6 Pages 881-885
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.881
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    A 56-year-old female complained of vertigo, hearing impairment and tinnitus. The diagnosis was Meniere's disease. One day she again complained of vertigo and visited our hospital for emergency treatment. Her hearing was improved during the vertigo attack, so she was considered to have Lermoyez's syndrome. She was examined by electrocochleography both during this attack of vertigo and about 6 months earlier when she was not complaining of vertigo. Positive SPs were recorded both times. Since a positive SP is often seen in patients with Meniere's disease, we thought that it indicated Lermoyez's syndrome, one of the subgroup of Meniere's diseases.
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  • Prognosis of Otitis Media with Effusion in Children and the Degree of Mastoid Pneumatization
    Takako Anda, Masahiko Kumagai, Takehiko Kokubun
    1992 Volume 85 Issue 6 Pages 887-894
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.887
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    We examined 858 ears of children aged 3 to 15 years to determine whether or not the prognosis of otitis media with effusion could be predicted from the degree of pneumatization. The area of the cellulae was determined by the square area technique, from X-ray films taken according to the method of Schüller. Four areas were considered: below 6cm2, 6-10cm2, 10-15cm2 and over 15cm2.
    When the area was over 15cm2, the disease was healed in nearly all ears, and rapid healing (within one year) was observed in 55%. When the area was 10-15cm2, the rate of healing was over 90%. When the area was 6-10cm2, the incidence of complication by secondary disease was 7%, and the percentage of ears requiring treatment for 5 years or longer was 8%, although the final rate of healing was close to 90%. But the area was 6-10cm2 at ages over 10 years, the incidence of secondary disease was 28%. When the area was below 6cm2, healing took even longer, and the incidence of secondary disease rose sharply to 26%, although the final rate of healing was 60%. But the area was below 6cm2 at ages over 10 years, the incidence of secondary disease was as high as 64%.
    These results suggest that patients with a cellula area below 10cm2 require careful treatment, and that those whose cellulae increase during the follow-up period tend to have a better prognosis.
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  • Clinical Features of Acute Mastoiditis in Infants
    Noritake Watanabe, Shigehiro Ueyama, Goro Mogi
    1992 Volume 85 Issue 6 Pages 895-904
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.895
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    The advent of broad spectrum antibiotics has allowed not only otologists, but also physicians and pediatricians easily to treat patients with acute infection of the middle ear cavity, and it has altered the clinical features and the course of acute mastoiditis. There are many fewer cases of acute mastoiditis with typical and classical signs and symptoms, such as ear pain, fever, aural discharge and postauricular abscess, and ‘classical’ mastoiditis has been largely replaced by a more chronic picture of ‘latent’ or ‘masked’ mastoiditis.
    We treated four infants with acute mastoiditis at the Medical College of Oita from 1981 to 1991. Two of them had typical signs and symptoms of classical mastoiditis secondary to acute otitis media. In the other two, the clinical features and course of acute mastoiditis were masked by the prior therapy with antibiotics. All four patients were successfully treated with simple mastoidectomy and postoperative antibiotic therapy. Etiological bacteria were cultured from two of the mastoids: Streptococcus pneumoniae and methicillin-(cephem)-resistant Staphylococcus aureus (MRSA).
    The clinical features of ‘classical’ and ‘masked’ mastoiditis in infants are compared and discussed.
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  • Maxillary Hemangioma; A Case Report and Review of the Japanese Literature
    Toru Handa, Hidekazu Yamamoto, Takeshi Akisada, Yukihiro Sato, Junshi ...
    1992 Volume 85 Issue 6 Pages 905-909
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.905
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    An 81-year-old woman was admitted to our hospital because of right maxillary swelling, pain and nasal obstruction. The medial wall of the right maxillary sinus protruded to the nasal septum. Plain X-ray films showed destruction of the lateral bony wall, and plain CT scans showed destruction of the posterior bony wall of the right maxillary sinus. The tumor was invading the parapharyngeal space. These findings suggested a malignant tumor of the right maxillary sinus.
    When needle biopsy was attempted intranasally, the needle could be inserted into the right maxillary sinus without any resistance. The pathological report was no malignancy, only coagulation.
    The right cheeck and gingiva showed swelling abruptly. Emergency CT showed an osteolytic lesion of the alveolar bone. Right maxillary sinectomy was done. The pathological report was fibrosis, hyalinization and capillary dilatation, these finding are compatible with hemangioma of the right maxillary sinus. The authors review the Japanese literature and discuss the ethiology of hemangiomas of the nose and paranasal sinuses.
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  • Clinical and Statistical Studies of Facial Trauma
    Shinya Matsunaga, Joji Hirota, Eiichiro Tokushige, Atsushi Sameshima, ...
    1992 Volume 85 Issue 6 Pages 911-916
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.911
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    We have treated 68 patients with facial trauma from 1979 to 1990 in the otolaryngologic clinic of Kagoshima University Hospital. There were 52 males and 16 females of all ages. The incidence was highest among 10-19-year old males.
    Traffic accidents caused the most traumas followed by fights and sports accidents. In 62 of the 68, there were facial bone fractures: nasal, maxilla, zygoma and orbital floor in almost equal numbers.
    Miniplates used for the fixation of maxillo-zygomatic bones were quite useful. Questionaires to the patients showed that post-operative distress was more often a cosmetic problem than functional disability.
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  • Sense of Taste in Children with Congenital Microtia
    Osamu Kawashima, Yoshihito Yasuoka, Tomio Yoshimi, Makiko Sakamaki
    1992 Volume 85 Issue 6 Pages 917-922
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.917
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    The sense of taste was evaluated in 20 children with congenital microtia. No laterality of the sense of taste was noted in any of the three areas examined in 16 patients without facial nerve palsy. In four patients with facial nerve palsy, no lateral difference in the sense of taste was noted in the areas supplied by the glossopharyngeal and major pyramidal nerves. However, the sense of taste was more diminished in the chorda tympani area on the side of the palsy in three of the four patients.
    A review of the literature and of the authors' patients suggests that the chorda tympani is present in some form even in children with microtia. In children with facial nerve palsy, however, hypoplasia or aplasia of the chorda tympani may occur.
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  • Reconstruction of Advanced Carcinoma of the Tongue and Oral Floor
    -A Case Report and Discussion of Heterogenous Multiple Primary Cancers in the Oral C avity-
    Kazuhito Matsubara, Katsuya Aoji, Kunio Nishikawa, Satoshi Koike
    1992 Volume 85 Issue 6 Pages 923-927
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.923
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    Recent progress in myocutaneous and free flaps has made repairs possible after wide resections of head and neck tumors.
    We treated a 67-year-old male patient with carcinoma of the tongue and oral floor.
    Reconstruction of large defects with the use of a pedicled latissimus dorsi flap and a free rectus abdominis flap was done after total laryngo-glossectomy and subtotal mandibular resection.
    The incidence of multiple primary cancer in patients with carcinoma of the tongue and oral floor is high, so periodic examimations are important.
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  • Benign Pleomorphic Adenoma of Parotid Gland with Unusual Course and Histological Findings; Report of Two Cases
    Yoshiyuki Tanigaito, Hirokazu Yoshida, Hitoshi Shimada, Kotaro Baba
    1992 Volume 85 Issue 6 Pages 929-935
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.929
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    Two female patients aged 37 and 46-years visited our out-patient clinic complaining of a tumor of the right parotid gland. A few weeks after the first visit, the tumors had become smaller. X-ray CT examinations of each patient showed a ring-shaped mass enhanced by the contrast medium in the lateral lobe of the parotid gland. The clinical course and the results of examinations led to a diagnosis of lymphadenitis or inflammatory cystic lesion. Both tumors were surgically extirpated, and histological examination showed benign pleomorphic adenoma with a wide area of central necrosis. The cause of the central necrosis is unknown. This type of benign pleomorphic adenoma is very rare but calls our attention to its possibility and the importance of accurate diagnosis and appropriate therapy.
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  • Adenosquamous Cell Carcinoma of Submandibular Gland; A Case Report
    Junshi Yamakawa, Yozo Orita, Takumi Hayashi, Tsuyoshi Yoshihiro, Toru ...
    1992 Volume 85 Issue 6 Pages 937-941
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.937
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    A 70-year-old man was admitted to the hospital because of a large left submandibular mass, 7×5×5cm. The tumor but it had been growing slowly for 50 years, enlarged suddenly, so we removed it together with adjacent lymph nodes. The pathohistological examination showed adenosquamous cell carcinoma accompanied by specific hyalinization. The hyalinization was considered to be related to the enlargement of the tumor and to the development of squamous cell carcinoma. Three years after the first operation, squamous cell carcinoma recurred. The adenosquamous cell carcinoma should be treated more vigorously at the initial stage.
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  • Surgical Treatment for Obstructive Sleep Apnea Syndrome
    Yoshifumi Uno, Ryusuke Saito, Makoto Kanatani
    1992 Volume 85 Issue 6 Pages 943-950
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.943
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    Ten patients with obstructive sleep apnea syndrome (OSAS) were treated surgically: Adenotonsillectomy for seven children and uvulopalatopharyngoplasty (UPPP) for three adults. Several respiratory and sleep parameters were evaluated by polysomunography (PSG).
    1. The clinical symptoms of loud snoring and excessive daytime sleepiness were completely relieved in all ten patients.
    2. Sleep apnea and the quality of sleep were significantly improved following adenotonsillectomy in all seven children. Enlarged tonsils and adenoids appear to be the major cause of OSAS in children.
    3. In the adults, sleep apnea and the quality of sleep were also improved following UPPP. However, there was considerable variation in the degrees of response. These therapeutic results indicate that OSAS in adults remains a complicated problem.
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  • Parapharyngeal Cyst; A Case Report
    Reiko Sato, Hitoshi Hentona, Hideki Muraoka, Soukei Maeka, Atsushi Kom ...
    1992 Volume 85 Issue 6 Pages 951-956
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.951
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    A rare case of parapharyngeal cyst arising from the second branchial cleft is reported.
    Radiologic imaging, especially CT and MRI, were useful in locating the cyst and showing that it extended from the lateral wall of the oropharynx to the base of the skull.
    A fenestration was made at the bottom of the cyst producing a communication between it and the oropharynx, since it was impossible to remove the cyst completely.
    Two years later there is no sign of recurrence of the cyst.
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  • Rates of Complete Cure of Abnormal Sensation in the Throat with Various Medicines
    Mikikazu Yamagiwa, Yasuo Sakakura, Teruhiko Harada, Masahiko Kubo, Har ...
    1992 Volume 85 Issue 6 Pages 957-961
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.957
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    During the past 10 years we have treated a total of 1, 132 patients with abnormal sensation in the throat with 11 active and 2 inactive oral medicines for two weeks or psychotherapy. The complete cure rate (CCR) was determined 1, 2 and 3 weeks after the start of treatment.
    Three Kampo medicines (hange-koboku-to, saiko-ka-ryukotsu-borei-to and saiboku-to), which are supposed to be mainly effective for psychosomatic disorders, and sulpiride, an antidepressant and considered to be effective for other central nervous system disorders, gave the best results: their CCR's were 13-18% at 1 week, 14-24% at 2 and 18-32% at 3 weeks.
    The CCR's for two (oxazolam and diazepam) of the three minor tranquilizers were high at 1 and 2 weeks (19-30%), but not at 3 weeks (13-14%). Symptoms recurred soon after the cessation of the therapy with these two medicines. The CCR of the other minor tranquilizer, alprazolam, was not high (8%) at 1 week, but it rose (13%) at 2 weeks and stayed at 13% at 3 weeks.
    On the other hand, the administration of other medicines [dosulepin hydrochloride (pure anti-depressant), hormone complex, lysozyme chloride (anti-inflammatory agent) and tiaprofenic acid (anti-inflammatory agent)] could not produce any better CCR's (3-7%) at 1 week than the two kinds of inactive medicines (3-4%) or psychotherapy without any drugs. At 2 and 3 weeks the CCR's for the former 4 medicines (7-16%) were slightly, but not significantly, higher than those (4-16%) for the inactive medicines or psychological treatment.
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  • Total Laryngectomy; 25 Cases
    Setsuo Nakamoto, Yoko Sugiyama, Masashi Inagaki
    1992 Volume 85 Issue 6 Pages 963-968
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.963
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    A clinical study was conducted of 25 patients who underwent total laryngectomy in our hospital from 1987 to 1990.
    1) Of these 25 patients, 18 had laryngeal cancer, 3 had esophageal cancer, 3 had cancer of the hypopharynx and 1 had thyroid cancer.
    2) The primary diagnosis in 8 of the 18 patients with laryngeal cancer was T1 or T2, and these patients underwent total laryngectomy for surgical salvage because of initial radiation failure.
    3) Recurrence rates after initial radiation were 10.5% for T1 glottic cancer.
    4) Patterns of failure after total laryngectomy for laryngeal cancer were stomal recurrence in 3 patients, neck metastasis in 2 patients and distant metastasis in 1 patient.
    5) The patients with esophageal (IuIm) and thyroid cancer had total laryngectomy because of paratracheal invasion.
    6) A simple objective evaluation of esophageal voice is described in this paper.
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  • Osteosarcoma of the Mandible; A Case Report
    Ryo Asato, Hideyuki Fukushima, Mitsuharu Nonomura
    1992 Volume 85 Issue 6 Pages 969-973
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.969
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    A 26-year-old man complained of swelling in the right parotid region of two months duration. Open biopsy at another hospital suggested osteogenic sarcoma. Pre- and postoperative chemotherapy (CDDP+THP-ADM) was administered. Hemimandibulectomy combined with neck dissection was performed. One and a half years later, the patient is alive with no evidence of local recurrence or metastasis.
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  • Metastasis of Renal Cell Carcinoma to Lingual Ectopic Thyroid; A Case Report
    Yosaku Shiomi, Yasuyuki Tasaka, Yoshiko Kano, Eiko Iwaki
    1992 Volume 85 Issue 6 Pages 975-979
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.975
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    A 62-year-old female came to our clinic because of oral bleeding. A tumor was found at the base of the tongue. Despite many examinations, including biopsy, we could not determine the nature of the tumor. It was resected, and pathological examination revealed a metastasis from a renal cell carcinoma to a lingual ectopic thyroid.
    If malignancy is suspected in the head and neck region, the possibility of metastatic tumor, especially from the urogenital tract, must be kept in mind.
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  • Toxic Shock Syndrome after Sinus Surgery; A Case Report
    Toshio Yamawaki, Hiroyuki Tsuji, Koichi Tomoda, Toshio Yamashita, Tada ...
    1992 Volume 85 Issue 6 Pages 981-985
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.981
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    Toxic shock syndrome (TSS) is characterized by the abrupt onset of fever, hypotension, rash, and multiple organ failure. This syndrome was first reported by Todd et al in 1978.
    This syndrome has also been described as a complication of nasal surgery (Thomas et al, 1982).
    The patient was a 16-year-old male with abrupt high fever, nausea, vomiting, diarrhea and rash 10 days after sinus surgery. Blood cultures were negative, but a nasal swab grew MRSA.
    Antibiotics and steroids were administered, and he recoverd in about a month without any sequellae.
    To our knowledge this is the first case of suspected TSS following sinus surgery in Japan.
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  • Vascular Architecture of the Eustachian Tube in the Rat
    -A Scanning Electron Microscopic Study-
    Takuya Ohmichi, Kazunori Nishizaki, Toshihiko Higashikawa, Yoshihiro N ...
    1992 Volume 85 Issue 6 Pages 987-991
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.987
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    The blood vessels of the eustachian tubes of rats were infused with methacrylate casting medium and observed three-dimensionally under a scanning electron microscope (SEM). The ascending pharyngeal artery and the ascending palatal artery gave off many branches around the nasopharyngeal orifice of the eustachian tube. The vascular architecture of the nasopharyngeal orifice was a dense network, extending to most of the other pharyngeal areas. The vascular system of the middle part of the tube was a one-layered coarse network. Arteries from the middle ear cavity and the pharynx supplied the tympanal orifice. The vascular network of this area was richer than that in other parts of the eustachian tube, and two or more vascular layers were observed clearly. From the point of view of the vascular supply, it is probable that pathological change around the nasopharyngeal orifice leads to stenosis of the tube and is related to the occurrence of lowered pressure in the middle ear cavity. However, the particular structure of the vascular layers in the tympanal orifice might also play an important role in the regulation of air pressure in the tympanic cavity.
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  • Gricothyroid-Lateral Gricoarytenoid Muscle Suturing
    -Experimental Study-
    Mitsuharu Nonomura
    1992 Volume 85 Issue 6 Pages 993-1001
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.993
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    A new method of dynamic reconstruction by suturing the cricothyroid and the lateral cricoarytenoid muscles was devised for the treatment of hoarseness due to unilateral recurrent laryngeal nerve paralysis.
    Eighteen adult dogs underwent this method after sectioning of a recurrent laryngeal nerve.
    Immediate postoperative observation during phonation revealed tension and movement of the affected vocal cord, which was adducted to reach the midline in 17 of 18 dogs. Over four months later, fiberscopic inspection revealed that adequate adduction was still present, and electrophysiological and histological examination showed that the affected lateral cricoarytenoid muscle was reinnervated by the external branch of the superior laryngeal nerve.
    Since this method is simple, and remobilization and tension during phonation are prompt and persistant, the clinical application of this method may serve as a new dynamic reconstruction for unilateral recurrent laryngeal nerve paralysis.
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  • Effect of Anticancer Drugs on CDDP-Resistant KB Cells
    Takuya Tachikawa, Hirobumi Kumazawa, Yoshio Hori, Yasuhiro Wada, Norik ...
    1992 Volume 85 Issue 6 Pages 1003-1009
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.1003
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    We investigated the effect of various anticancer drugs on CDDP-sensitive KB cells and CDDP-resistant KB cells (KBrc cells). The effect of CDDP and CDDP analogues on the two tumor cell lines were evaluated by in vitro cell growth curves. KBrc cells were resistant to both CDDP and CDDP analogues, which were effective against KB cells. No significant difference between KB cells and KBrc cells was observed in terms of the effect of 5FU and peplomycin.
    Futhermore, to investigate the mechanism of resistance of KBrc cells to CDDP and CDDP analogues, we compared the intracellular platinum concentration of two tumor cell lines after the addition of CDDP and CDDP analogues to the cell culture. The platinum concentration in KBrc cells was much lower than in KB cells, when CDDP was added to the cell culture in concentrations of 10μg/ml and 100μg/ml. These results indicate that a difference in the intracellular platinum accumulation may be involved in the mechanism of resistance of CDDP-resistant tumor cells.
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  • Best Kampo Medicines for Patients with Globus Pharyngeus in Relation to Background Factors
    Katsuhisa Ikeda, Tomonori Takasaka
    1992 Volume 85 Issue 6 Pages 1011-1015
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.1011
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    Fifty-four patients with globus pharyngeus were classified by Jitsu Sho scores and the Cornell Medical Index (CMI) health questionnaire. Three different Kampo medicines, saiboku-to (TJ-96), bukuryoin-go-hangekoboku-to (TJ-116), and kamikihi-to (TJ-137) were given, and their clinical usefulness was evaluated.
    The number of patients showing Jitsu Sho, Kyo/Jitsu Chukan Sho, and Kyo Sho was 9, 33, and 12, respectively. In regions I, II, III, and IV of CMI there were 16, 18, 17, and 3 patients, respectively.
    The overall therapeutic efficacy was marked in 20%, moderated in 41%, and slight in 15%. TJ-116 was found to be most effective in patients with Jitsu Sho and Kyo/Jitsu Chukan Sho, while TJ-96 was most useful for patients with Kyo Sho. The highest efficacy was obtained in TJ-116 for patients with regions I and II, and in TJ-96 for those with region III.
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  • Technique and Trick of the Intra-Arterial Infusion to the Superficial Temporal Artery
    [in Japanese]
    1992 Volume 85 Issue 6 Pages 1016-1017
    Published: June 01, 1992
    Released on J-STAGE: November 04, 2011
    DOIhttps://doi.org/10.5631/jibirin.85.1016
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