Okayama Igakkai Zasshi (Journal of Okayama Medical Association)

Experimental study on cerebral venous circulatory disturbance

Toshikazu SAIJO

1992 Volume 104 Issue 9-10 Pages 871-884
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_871

JOURNAL FREE ACCESS

Show abstractHide abstract

A new experimental model of cerebral venous occlusion was developed and the cerebral hemodynamics and water content using this model were studied.
An anatomical study of the cerebral venous system using methacyrl resin showed that the venous system was composed of superficial and deep veins. The superficial veins drained into the superior sagittal sinus (SSS). The SSS was connected to internal and external jugular veins via the transverse sinuses and diploic veins (DV), respectively. The cats were divided into three groups on the basis of the occlusion sites as follows; Group I: SSS occlusion, Group II: DV occlusion, Group III: occlusion of both the SSS and DV. Intracranial pressure (ICP) and cerebral blood volume (CBV, photoelectric method) were monitored continuously. Local cerebral blood flow (1-CBF) and water content were measured by hydrogen clearance and gravimetric methods, respectively. Somatosensory evoked potential (SEP) was also recorded. Evans blue was injected intravenously to evaluate blood brain barrier permeability.
There were no significant changes in ICP, 1-CBF or N1 latency of SEP after the occlusion in Group I or II. However, in Group III, 1-CBF decreased significantly 2 hours after the occlusion as ICP increased gradually. N1 latency of SEP was prolonged and water content increased significantly. CBV increased immediately after the occlusion. There was no extravasated Evans blue.
The increase in CBV and water content during sinus occlusion appeared to have led to intracranial hypertension and decrease of 1-CBF, which resulted in neural dysfunction. The brain edema in this model seemed to be hydrostatic edema or cytotoxic edema.

View full abstract

Download PDF (3754K)
The effect of nutritional intake on energy metabolism in postoperative patients after gastrointestinal surgery

Ken YOSHIZANE

1992 Volume 104 Issue 9-10 Pages 885-895
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_885

JOURNAL FREE ACCESS

Show abstractHide abstract

Many studies have shown that enteral nutrition (EN) has nutritional effects comparable to total parenteral nutrition (TPN). However, the energy metabolism of the two different nutritional methods remains undefined. The two nutritional methods were compared by measuring the resting energy expenditure (REE) and nutritional assessment in postoperative patients after gastrointestinal surgery. The effects of different amounts of EN were also evaluated. Patients were divided into three groups: Patients who were fed by EN of 30 Cal/kg/day (Group I, EN 30: n=8), patients who were fed by EN of 40 Cal/kg/day (Group II, EN 40: n=8), and patients who were fed by TPN of 30 Cal/kg/day (Group III, TPN:n=8). REE was measured by the Datex indirect calorimetry and nutritional assessment included the measurements of triceps skinfold thickness (TSF), arm muscle circumference (AMC), albumin and rapid turnover proteins. % REE/BEE of EN30, EN 40 and TPN was 122.5±14.3%, 138.2±16.8% and 107.6±10.5% respectively. The RQ for the three groups was about 1.0, which means the energy source of all regimens is carbohydrate. The TPN group showed a significantly higher RQ than the EN groups, but there was no difference in albumin or transferrin. There was no difference in nutritional effect between EN 30 and EN 40. No difference was found in anthropometric effects among the three groups.
These findings suggest that 30 Cal/kg/day would be preferable to 40 Cal/kg/day in energy supply of enteral nutrition and that the energy expenditure of EN is higher than that of TPN under 30 Cal/kg/day nutrition. There is no difference among the three methods in terms of nutritional effects.

View full abstract

Download PDF (2318K)
Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques

Part 1. Drug sensitivity test in lung cancer using human tumor clonogenic assay

Nobuyasu KISHIMOTO

1992 Volume 104 Issue 9-10 Pages 897-904
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_897

JOURNAL FREE ACCESS

Show abstractHide abstract

The selecton of a series of effective drugs for individual patients in advance of drug therapy should increase the success of cancer chemotherapy. The human tumor clonogenic assay was evaluated as a drug sensitivity test mainly in patients with lung cancer. Tumor cells from malignant pleural effusion, tumor-positive bone marrow aspirates, and tumor tissues from the primary or metastases were used as specimens. Prior to plating, tumor cells were exposed to 4-hydroperoxy ifosfamide, adriamycin, mitomycin C, methotrerxate, and cisplatin for one hour at graded concentrations which were achievable in man. Of 151 specimens tested, 93 (62%) yielded at least 5 colonies in the control plates containing no drugs. Colony growth (≥5/plate) was seen in 80% of squamous cell carcinoma, in 73% of small cell carcinoma, in 62% of adenocarcimoma, and in 40% of large cell carcinoma. Among the 93 specimens with colony growth, 62 yielded more than 30 colonies in the control plates and were put in force for drug sensitivity testing. Of 37 instances in which the clinical response to a certain drug was examined, 34 (92%) showed an in vitro-in vivo correlation, showing a true positive rate of 57% and a true negative rate of 100%. In summary, the human tumor clonogenic assay would be an excellent technique for testing the drug sensitivity of the tumor in individual patients tumor.

View full abstract

Download PDF (1186K)
Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques

Part 2. Biological characteristics of five newly established small cell lung cancer cell lines

Nobuyasu KISHIMOTO

1992 Volume 104 Issue 9-10 Pages 905-913
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_905

JOURNAL FREE ACCESS

Show abstractHide abstract

Five small cell lung cancer (SCLC) cell lines in culture were established and designated as SBC-1, 2, 3, 4 and 5. SBC-1, 2, 4 and 5 were derived from tumors of intermediate cell histology, and SBC-3 was from a tumor of oat cell histology. All the cell lines represented a characteristic cytomorphology of SCLC when examined by papanicolaou staining and by electron microscopy. Their biological characteristics such as doubling time, clonogenic activity, heterotransplantability in nude mice, and capacity of hormone production in culture revealed that each cell line had a distinct biological feature. The SCLC cell lines reported here would be useful as a tool for cellular pharmacology of new drugs and drug resistance.

View full abstract

Download PDF (2744K)
Development of double cancer in small cell lung cancer patients treated with intensive chemotherapy

Kenichi MIYAKE

1992 Volume 104 Issue 9-10 Pages 915-922
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_915

JOURNAL FREE ACCESS

Show abstractHide abstract

Development of double cancer was evaluated in 337 small cell lung cancer patients who had received intensive chemotherapy with or without radiotherapy. Of them, 14 patients (4.2%) developed a second malignancy: non-small cell lung cancer in six, stomach cancer in four, acute myelogenous leukemia in two, liver cancer in one, and esophagus cancer in one. The relative risk for the development of double cancer calculated by person-year method utilizing age and sex adjusted cancer incidence in Japan was 2.75-fold (P<0.01). The risk of non-small cell lung cancer (8.75-fold) and acute myelogenous leukemia (37.82-fold) was particularly high.
The cumulative risk for the development of double cancer was 2.0% at 1 year, 4.1% at 2 years, 14.3% at 3 years, and 100% at 8.1 years.
Of 27 patients who survived disease-free for more than 2 years, 10 patients died; five patients (50%) died of double cancer, two died of infectious disease, and only three patients died from recurrent small cell lung cancer.
These findings indicate that a cautious follow-up program for the detection of double cancer is indicated in patients with small cell lung cancer.

View full abstract

Download PDF (452K)
Combined resection of lung cancer and invaded aorta with the use of simple temporary bypass: A case report

Fumiyuki INOUE, Yasuaki KAMIKAWA, Yoshio NAOMOTO, Akira GOUCHI, Kunzo ...

1992 Volume 104 Issue 9-10 Pages 923-929
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_923

JOURNAL FREE ACCESS

Show abstractHide abstract

Left pneumonectomy and concomitant resection of the invaded aorta were performed by the simple temporary bypass method. The patient was a 59-year-old male with the chief complaint of left thoracic pain. The 57×43×35mm tumor was in a region centering on segment 6 of the left lung and had infiltrated the descending aorta. It was diagnosed as T4NOMO, Stage IIIb. A bypass for blood flow was established between the aortic arch above the invasion and the left femoral artery, after ligation of the pulmonary artery and vein and closure of the left bronchial stump. Vascular blocking forceps were applied to the descending aorta above and below the tumor infiltration, and two thirds of the circumference of the invaded aortic wall, 4.0×3.0cm, along with the tumor, was resected. Reconstruction was performed with an 18mm Cooly double velour graft. Blood pressure was monitored with a pressure probe inserted into the right femoral artery. It did not fall below 60mmHg during the operation. Local recurrence was observed 10 months post- operatively, and the patient is now receiving radiation therapy.

View full abstract

Download PDF (2375K)
Thermographic findings as a prognostic indicator for breast cancer: Correlation between temperature increase and angioarchitecture

Masakazu MURAKAMI

1992 Volume 104 Issue 9-10 Pages 931-941
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_931

JOURNAL FREE ACCESS

Show abstractHide abstract

The thermographic findings of 191 patients with Stages I-III breast cancer were retrospectively evaluated to determine the prognostic indicators of disease-free survival in both the whole study population and in each histological stage. The angioarchitecture of 75 breast cancer specimens was subsequently examined morphometrically using an immunohistochemical method, and was then compared with the extent of increase in the temperature at the tumor site.
The extent of increase in the temperature was more closely related to the prognosis than was the thermal pattern.
In stage II cancer (n=57), patients with lesions that showed a temperature increase>1.5°C had a poorer prognosis than the patients with hypothermic regions (p<0.05).
The range of skin temperature elevation at the tumor site correlated with the vascular changes in the skin above the tumor rather than with changes within or around the tumor in all of the patients.
The increase in temperature above a tumor was concluded to be useful for assessing the prognosis and the grade of malignancy of breast cancer. The skin blood flow was also suggested to have the closest relationship with thermographic findings and the extent of the increase in blood flow to be a prognostic indicator for breast cancer.

View full abstract

Download PDF (2542K)
[title in Japanese]

1992 Volume 104 Issue 9-10 Pages 943-947
Published: 1992
Released on J-STAGE: October 29, 2012

DOIhttps://doi.org/10.4044/joma1947.104.9-10_943

JOURNAL FREE ACCESS

Download PDF (1386K)
[title in Japanese]

1992 Volume 104 Issue 9-10 Pages 949-960
Published: 1992
Released on J-STAGE: October 29, 2012

DOIhttps://doi.org/10.4044/joma1947.104.9-10_949

JOURNAL FREE ACCESS

Download PDF (2441K)
[title in Japanese]

1992 Volume 104 Issue 9-10 Pages 961-968
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_961

JOURNAL FREE ACCESS

Download PDF (400K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 969-970
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_969

JOURNAL FREE ACCESS

Download PDF (90K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 971-972
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_971

JOURNAL FREE ACCESS

Download PDF (84K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 973-974
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_973

JOURNAL FREE ACCESS

Download PDF (94K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 975-976
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_975

JOURNAL FREE ACCESS

Download PDF (78K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 977-978
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_977

JOURNAL FREE ACCESS

Download PDF (490K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 979-980
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_979

JOURNAL FREE ACCESS

Download PDF (97K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 981-982
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_981

JOURNAL FREE ACCESS

Download PDF (491K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1992 Volume 104 Issue 9-10 Pages 983-984
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_983

JOURNAL FREE ACCESS

Download PDF (91K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 985-986
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_985

JOURNAL FREE ACCESS

Download PDF (106K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 987-988
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_987

JOURNAL FREE ACCESS

Download PDF (96K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 989-990
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_989

JOURNAL FREE ACCESS

Download PDF (88K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 991-992
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_991

JOURNAL FREE ACCESS

Download PDF (75K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1992 Volume 104 Issue 9-10 Pages 993-994
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_993

JOURNAL FREE ACCESS

Download PDF (445K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 995-996
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_995

JOURNAL FREE ACCESS

Download PDF (102K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 997-998
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_997

JOURNAL FREE ACCESS

Download PDF (772K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 999-1000
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_999

JOURNAL FREE ACCESS

Download PDF (97K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1992 Volume 104 Issue 9-10 Pages 1001-1002
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_1001

JOURNAL FREE ACCESS

Download PDF (98K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1992 Volume 104 Issue 9-10 Pages 1003-1004
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_1003

JOURNAL FREE ACCESS

Download PDF (105K)
[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1992 Volume 104 Issue 9-10 Pages 1005-1006
Published: 1992
Released on J-STAGE: March 30, 2009

DOIhttps://doi.org/10.4044/joma1947.104.9-10_1005

JOURNAL FREE ACCESS

Download PDF (94K)

Register with J-STAGE for free!