The Weil-Felix reaction test performed on the blood sera of healthy persons in Aioi village which had been affected with “Umayado-Disease” and 51 other cities, towns and villages in Kagawa Prefecture revealed as follows:
1) The aggultination titer against the OXK strain on the blood sera of healthy persons in Aioi village is remarkably higher as compared with that in other areas in Kagawa prefecture. This fact shows that the inhabitants of Aioi village are constantly exposed to a danger of the infection of this disease.
2) The strength of the OXK reaction observed in Aioi village seems to be varied according to lacalities; i.e., it is higher at the localities nearer the mountaineous area. In other words, the possible extent of this disease's infection is inversely propotional to the geological elevation of land.
3) My observation on the amount of the antigen produced against the OXK strain shows that the possible extent of the infection of this disease is expecially remarkable at Umayado and Sakamoto.
4) The antigen titer against the OXK strain in healthy persons in Aioi village always changes according to the seasons of the year. For instance, it is constantly higher in autumn, and in spring it drops lower. In view of this fact, it is possibly understood that this disease prevails chiefly in summer-time.
5) With the people in Kagawa prefecture as a whole, the strength of the OX₁₉ reaction becomes higher among the people westward, and lower eastward. This is in coincidence with the conditions of the prevalence of fleck fever in this prefecture.
6) The strength of the OXK reaction, with the people of Kagawa prefecture as a whole, is higher in the easten part of the prefecture, including Aioi village, and in the western part the antigen against the OXK strain has hardly been discovered so far.

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The auther took observation to find some clue for pathogenesis of schizophrenia, on certain physical natures of erythrocytes. attacking the most general somatic aspect above all, on their diameter, specific gravity, number, hematocrit value, volume, thickness, spheric index (spread of erythrocytes), inverse spheric index (swell or dilation of erythrocytes), as well as their resistance against NaCl solution.
In Ist chapter, the auther took investigation to know whether the erythroeytes of schizophrenics had specific natures. compared to those of normal subjects or non-schizophrenics; moreover examined if there existed any difference even for various clinical types or states of schizophrenics.
In 2nd chapter, the auther investigated about changes in the physical properties of schizophrenic erythrocytes by electric shock therapy, besides if they had certain special differences from those of depression and neurosis, and examined the changes between acute or chronic progressive schizophrenic types, by comparative study.
In 3rd chapter, the auther examined as to those effects occurred by insulin shock therapy on the physical properties of schizophrenic erythrocytes.
The results of the investigation were summarized as follows;1st chapter.
1) Examined; normal, 20 cases; non-schizophrenics, 22; schizophrenics, 60; respectively, male and female were same in number.
2) Schizophrenic erythrocytes are discovered to have a large diameter, rather thin, and small in volume.
Their spheric index proved below 0.23; their inverse spheric index, above 40. The specific gravity of the total blood and the blood plasma proved heavy, but that of erythrocytes suffered no changes. As to resistance, they proved an incrcase in the width of it due to the shift of the maximum resistance, which brought about an increase in their resistance.
3) The volume, thickness, spheric index, and inverse spheric index etc. of schizophrenic erythrocytes, compared to those of non-schizophrenics, indicated specific changes.
4) Erythrocytes in excitatory state of schizophrenic is larger and flatter than those in stuporous; as special features in stuporous state, schizophrenic erythrocytes proved light in their gravity, while numerous.
5) While becomes remission, the diameter of erythrocytes reduces compared to worse time: thickness, spheric index, inverse spheric index, resistance, and number, all come back to their former normal state, but on the contrary, their specific gravity and volume indicate even a rise.
2nd chapter.
1) The physical changes taking place in erythrocytes in those three periods, i.e., immediately before as well as after, 90 minutes after E. C. T., were duly laid under observation, employing 26 schizophrenic cases, 12 non-schizophrenic; summing up, 38 cases.
2) Such as the erythrocytes diameter, the specific gravity of total blood as well as blood plasma, hematocrit value, volume, thickness of erythrocytes. each showed certain degree of increase by E. C. T.; after 90 minutes, it relapsed to the direction of before E. C. T., and the specifie gravity of erythrocytes decreased immediately after E. C. T., contrary to the changes of total blood or blood plasma, and then it became heavier again after 90 minutes. Both spheric index and inverse spheric index altered their course toward increase by E. C. T., which recovered as before, after 90 minutes.
3) Between schizophrenics and non-schizophrenics, essential differences are as to those changes in the specific gravity of erythrocytes and in their number, the specific gravity in schizophrenics being slow to regain its self-same state, while their number in non-schizophrenics though regained normal self, it keeped on abating trend in schizophrenics. The resistance of schizophrenic erythrocytes was weakend by E. C. T. and recovered afterwards. The width of resistance, though enlarged itself, after a while underwent certain shrinkage.

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I made various experiment to know which is better artificial light-source, incandescent lamps or fluorescent lamps, from the viewpoint of eye-hygiene and illumination engineering.
In this part, experiments were made with colored and uncolored test-charts in the effort to resolve the matter from the point of speed of seeing, and the following conclusion was reached.
(1) There is a stright line relation between speed of seeing and logarithm of intensity of illumination, and the relation appears nearly same with each light-sources.
(2) Speed of seeing increases as the intensity of illumination increases, and the rate of increase is great in low intensity of illumination and small in high. But the relation seems to differ slightly with the light-source and test-charts.
(3) Speed of seeing varies with the luminosity-contrast, and in general, high speed of seeing is obtained in high luminosity-contrast. But this relation slightly varies with light-sources and the intensity of illumination.
(4) Speed of seeing, throughout each test-chart and intensity of illumination, is highest with de luxe daylight fluorescent lamp, and daylight fluorescent lamp, de luxe white fluorescent lamp, white fluorescent lamp, incandescent lamp follow in the order.
(5) So from the view-point of speed of seeing, it is considered that fluorescent lamp, especially de luxe daylight fluorescent lamp is superior artificial light to incandescent lamps in visual tasks.
(6) From the view-point of speed of seeing, the required intensity of illumination in reading, if colored pages included, is considered to be 300 H. Lux at the minimum.

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Reading tests were made with Ishihara's Charts (10th edition) under incandescent lamps, daylight fluorescent lamps. de luxe daylight fluorescent lamps, mixed light of daylight fluorescent lamps and incandescent lamps, and neutral daylight.
The result was as follows:
The reading accuracy was highest under the de luxe daylight fluorescent lamp, and neutral daylight. the daylight fluorcscent lamp, mixed light of the daylight fluorescent and the incandescent lamps followed in this order with slight differences, and the incandescent lamp was the lowest.

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I made a test of vision under the illumination of 200 H. Lux using incandescent lamps and de luxe daylight fluorescent lamps as the light-source.
Fourteen kinds, 140 sheets of Landolt's test-card in various color-contrast with black, white, green, blue, red and yellow were used as the test material.
(1) In all cases de luxe daylight fluorescent lamps gave better vision than incandescent lamps.
(2) The difference was 1.78% at the minimum, 26.08% at the maximum, and 9.67% in the average.
(3) The marked differences were 26.08% in white object on yellow background, 25.04% in yellow object, 24.10% in red object, 11.74% in green object and 10.48% in blue object each on white background.
(4) These differences are considered mainly due to the color rendoring properties of both light-sources.
(5) The relation between color-contrast and vision is affected by the nature of light-sources in various degree according to the variety of coor-contrast.

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The present work was carried on by means of 2 dimensional paper chromatography. ‘where phenol and lutidine-collidine were used. The following results were obtained.
1) Aspartic acid, glutamic acid, glutamine, γ-aminobntpric acid and taurine were remarkably demonstrated, glycine and alanine moderately, while serine, β-alanine, valine as well as leucine, slightly.
2) The free amino acids found in the brain are almost non-essential amino acids.
3) Certain fixed relation in quantitative ratio has been recognizable among glutamic acid, γ-aminobutyric acid and glutamine.

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The change of the free aminoacids in the cat-brains treated repeatedly by electric shocks was in vestigated. Both the systems of glutamic acid→γ-aminobutyric acid and glutamic acid→glutamine were influenced by the treatment. Especially the change in the former proved more remarkable than in the latter. In other words, glutamic acid decarboxylase has been activated and in the latter system, glutamine, has been formulated, though in a slight degree. These facts are considered to show certain rise in the brain function as results of E. C. T.

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Have measured the amount of the free amino acids found with in cat's brain that has undergone the repeated Insulin shock, same as often used in curing psychotic patient: and which. according to paper chromatography, proved as follows:
1) As seen from the point of quality, no definite change whatever has happened.
2) Glutamic acid and γ-aminobutyric acid increased in quantity.
3) The ratio γ-aminobutyric acid to glutamic acid showed an increasing tendency.

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[in Japanese]

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Some investigations having been directed toward the measurement of carbonic anhydrase activity in the erythrocytes either of any normal subject, schizophrenic, or non-schizophrenic patient, together with a study as to the correlations that exsist between that and electric or insulinshock, or various toxines of vegetative nervous quality, (e.g., adrenalin, pilocarpine, atropine etc.) that should by administered to it;
1) In the case of schizophrenics, the activity of carbonic anhydrase has proved in general to be rather low than in normal subjects; exitatory type has proved the lowest. Then, in the course of transition from acute type to chronic, or improving, the activity has inclined to increase.
2) As for those non-schizophrenic patients, in the greater half it has proved to be lower than in normal subjects; with such diseases as hysteria, depression, or neurosis, which chiefly are consisted of psychiatric symptoms, it has proved distinctly to be lower than in those diseases in which physical symptoms are considered with importance such as hydrocephalus, brain haemorrage, and chronic toxicity.
3) When treated by electric or insulinshock, anhydrase activity both of schizophrenics or non-schizophrenic patients show a sure drop. If adrenalin may be injected, it would prove an increase invariably; in case atropine is applied, a drop in activity will occur in the schizophrenic group, while various attitude may take place among the non-schizophrenic groupes. Toward the injection of pilocarpine, both groups repsond with various attitudes.
4) I have tried certain investigations as to the significance those changes of anhydrase activity may suggest to us.

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