Background and Aims: Radioimmunotherapy (RIT) appears as one of the most effective treatment options for patients with relapsed or resistant non-Hodgkin's lymphoma (NHL). Our aim was to evaluate the role of pre-RIT
18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) as an early predictor of
90Y-Ibritumomab tiuxetan treatment response.
Methods: We included consecutive 20 patients with relapsed NHL (10 males; mean age, 58.5±8.9 years old) who were treated with
90Y-Ibritumomab tiuxetan. FDG-PET/CT was performed before and after treatment. Semiquantitative parameters of all measurable FDG-avid lesions were measured and averaged. A measurable FDG-avid lesion was defined as a lesion that showed FDG uptake higher than liver with a diameter more than 1cm. Treatment response was determined by visual assessment based on a five-point score criteria from FDG-PET/CT after treatment.
Results: Fourteen patients (70%) were classified as responders and the other six patients (30%) as non-responders. All semiquantitative parameters except for MTV demonstrated significantly lower values in the responders compared with the non-responders (p<0.05).
Conclusions: Semiquantitative evaluation by SUVmax, SUVpeak, and TLG before treatment were useful as early predictors of
90Y-Ibritumomab tiuxetan treatment response.
抄録全体を表示