The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 37, Issue 3
Displaying 1-24 of 24 articles from this issue
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Photograph
Special Article
Case Reports
  • Endocrine-Candidiasis Syndrome
    —Report of a Case of Chronic Mucocutaneous Candidiasis Associated with Idiopathic Hypoparathyroidism—
    Tadahiko MATSUMOTO, Shozo HONBO, Noriaki WATANABE
    1975 Volume 37 Issue 3 Pages 345-353
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.345
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    A 12-year-old girl with chronic mucocutaneous candidiasis of 8 years' duration developed parathyroid insufficiency. Endocrine evaluation of the patient led to the finding of idiopathic hypoparathyroidism. Oral administration of clotrimazole and normalization of serum calcium level by dihydrotachysterol therapy resulted in improvement of the infection which had previously been resistant to the prolonged antifungal treatment. The patient failed to demonstrate cutaneous delayed hypersensitivity to Candida antigen and also to PPD and specific humoral antibody to Candida albicans. In vitro studies of cellmediated immunity revealed intense positive blastogenic response to the Candida antigen and negative migration inhibitory factor production to the antigen. According to our hypothesis “immune deviation theory” in the pathogenesis of chronic mucocutaneous candidiasis, the term “pre-deviation state” is proposed in explanation of immunological condition of this case. Relationships between the Candida infection and the endocrine dysfunctions, and other implications of this syndrome are also discussed. A review of the literature suggested that the patient may be the first reported case of “endocrine-candidiasis syndrome” in Japan.
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  • Essential IgG Cryoglobulinemia with Purpura and Cold Urticaria
    Hiromu KODA, Masakazu ASAHI, Akiko KANAIDE
    1975 Volume 37 Issue 3 Pages 354-359
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.354
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    A eighty-year-old woman, who had repeated episodes of widespread purpura, necrotic cutaneous ulcerations and cold urticaria. No disease of other organ systems had been observed. The diagnosis of cryoglobulinema was established by laboratory studies. The cryoglobulin consisted of IgG immunoglobulin only. Attempts at the passive transfer of cold sensitivity by the serum and cryoprecipitate from the patient were successful.
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  • Eccrine Poroma
    Eizo FUKUDA, Shoji TOSHITANI, Tsuneo OSHIMA
    1975 Volume 37 Issue 3 Pages 360-364
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.360
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    A 71 year-old woman complained of an asymptomatic brown tumor on her left sole, which had developed over the past 6 years. Histologically from the general growth pattern and the morphological characteristics of individual cells forming the tumor nests, this case is considered an eccrine poroma described by Pinkus et al. Although this case is rich in cystic structures, sweat duct-like lumina with PAS-positive, diastase-resistant cuticle are not present. However, melanin granules were found within a large number of the tumor cells. For that reason, it seemed better to diagnose this case as a pigmented eccrine poroma.
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  • A Case of Accidental Vaccinia
    Akinori NAKAMURA, Katsumi OGATA
    1975 Volume 37 Issue 3 Pages 365-367
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.365
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    This is a case report of generalized vaccinia which developed in a 31 year old man. It is believed that he was accidntally infected by his 17 month old daughter after her first small pox vaccination. He has a previous history of serious bronchial asthma from his childhood.
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  • Epidermolysis Bullosa Dystrophica et Albo-Papuloidea (Pasini), Especially on Its Etiology
    Hiroshi KUWAHARA
    1975 Volume 37 Issue 3 Pages 368-378
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.368
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    The author treated a typical case of epidermolysis bullosa dystrophica et albo-papuloidea (Pasini). The patient was a 33-year-old Japanese woman with vesicles on the extremities, dystrophic nails and whitish, erythematous papules over the trunk. Her mother has the same disease, and the number of family members in her family history (relatives) is relatively few. Other symptoms of the patient included sexual function impairement and loss of the pubic and axillary hair. Laboratory examinations revealed a pattern, reversal of the pattern of diabetes mellitus in the glucose-fatty acid cycle suggesting the priority of the insulin-dependent pathway. Other findings were the uneasiness of the parasympathetic system and a transient increase of BMR. She responded to chloroquine phosphate and vitamin E, but the administration of DDS worsened her condition. These findings suggest an abnormal pathway in the pentose phosphate glycogenesis either resulting from, or in the abnomal metabolism of the lipids, increased glycolysis, increased Touster pathway and increased metabolism of amino acids, leading to the priority of the insulin-dependent pathway and overproduction and deposition in tissue of glycoprotein. Through the disturbance of synthesis of steroids, abnormalities of the various endocrine organs resulted, with sexual gland function impairement as its center. These speculations need re-evaluation from the standpoints of enzymology and endocrinology.
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  • Gnathostomiasis
    —Component of Alimentary Canal of Gnathostoma spinigerum—
    Akinobu SHOUJI, Motohiro ISEKI, Taro IKEDA
    1975 Volume 37 Issue 3 Pages 379-384
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.379
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    Thirty-eight patients with gnathostomiasis in whom the parasites were succeedingly removed have been reported in Japan up to now. A case presented is a 24 years old Japanese wife who had intermittently had a slow moving cutaneous swelling since she was 15 years old. On the first consultation, she had only one reddish papule on the left trunk. The lesions was taken by 5 mm. punch, and cut in serial section. Fortunately, the larva of Gnathostoma spinigerum by the form of hooklets on the head bulb. Microscopic studies of the larva revealed the esophagus, intestine and the other internal organs. The esophageal cells consisted of basophilic substance which contained a little iron. In the intestine, microvilli were found on the inside of the intestinal cells which had hemoglobin around the many brownish pigmented granules resembling melanin. Much attention must be payed for a papule or vesicular lesion in gnathostomiasis because it contains the larva, and is easily removed with a punch biopsy.
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Clinical Study
  • Treatment of Chromomycosis with 5-Fluorocytosine
    On 5-Fluorocytosine
    Harukuni URABE
    1975 Volume 37 Issue 3 Pages 385-386
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.385
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  • Experimental Study on 5-Fluorocytosine Against Dematiaceous Fungi
    Yoshinori SUENAGA, Masaru YASUDA, Shozo HONBO
    1975 Volume 37 Issue 3 Pages 387-390
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.387
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    The minimal inhibitory concentrations (MIC) of 5-fluorocytosine (5-FC) against dematiaceous fungi were in the range of 0.78 to 50/μg/ml. The MIC of Hormodendrum pedrosoi and H. dermatitidis repeatedly cultured on the medium containing 5-FC increased more than 500 μg/ml. The effect of 5-FC on the experimental chromomycosis in mice failed to be proved.
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  • The Course of a Case of Chromomycosis Treated with 5-Fluorocytosine
    Hiroyuki MARUTA, Kikuo MINAMI
    1975 Volume 37 Issue 3 Pages 391-396
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.391
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    5-Fluorocytosine (5 FC) was used orally for the treatment of a case of chromomycosis in a 46-year-old housewife. At 15 weeks after the onset, 5-FC was very effective and she was almost cured clinically. Histologically and electron microscopically, spores in the dermis were markedly decreased in number and all of them had suffered a change of shape or been destroyed. However 33 weeks later, she had a complete relapse.
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  • A Chromomycosis Case Treated with 5-Fluorocytosine
    Katsutaro NISHIMOTO, Hideaki YAMAURA, Kazuki MAEJIMA, Humiko HUNAMOTO
    1975 Volume 37 Issue 3 Pages 397-403
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.397
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    A chromomycosis case, 28 female, who was treated with oral and topical administration of 5-fluorocytosine (5-FC) was reported. The patient had had widespread granulomatous skin lesions since twelve years of age, and had been treated by intravenous and topical amphotericin B, surgical exision and also thiaben-dazole. The effect of oral 5-FC treatment on chromomycosis lesions was remarkable in the initial two months and regression of granulomatous vegetations and subcutaneous nodules were observed. But soonafter the effect of 5-FC was reduced by the elevation of MIC on the causative fungus, Phialophora verrucosa. Light and electron microscopic examinations of the skin lesions during 5-FC therapy were performed and the influence of the drug on morphology of fungus in the host tissue was in-vestigated.
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  • Studies of Fibrinolytic Activity in the Skin
    —Inhibitors of Fibrinolysis in Normal Skin and Inflammatory Lesion—
    Fumio SHIGEMI, Junya ISHIMURA, Toshio OTSUKA
    1975 Volume 37 Issue 3 Pages 404-409
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.404
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    Normal skin was cut with a cryostat in four layers along skin surface and biopsies from the affected areas (contact dermatitis, erythroderma) were divided in epidermis and corium. Each sample was homogenized and separated into supernatant and sediment. Supernatants were investigated on fibrin plates for their fibrinolytic activity, their inhibitor activity against urokinase, and SK-induced fibrinolytic activity.
    1) It is suggested that there were inhibitors of fibrinolytic activity not only in the epidermis but also in skin appendages.
    2) Antifibrinolytic activity was demonstrated in the corium of the affected area. The decrease or absence of fibrinolysis in some inflammatory states could be due to the presence of inhibitors.
    3) In the lower dermis of normal skin in which there was not an inhibitor existed SK-induced fibrinolytic activity, the distribution pattern of SK-induced activity was not similar to that of the inhibitors in supernatants.
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  • Studies on Adrenocortical Suppression Following Percutaneous Absorption of Topical Corticosteroids
    —Observations on 0.1% Triamcinolone Acetonide Ointment (Ledercort ointment) Applied under Occlusive Dressing—
    Shuhei SHIMAO, Yasuyuki SHIMIZU, Miki ASO, Motoyuki MIHARA, Taeko INOU ...
    1975 Volume 37 Issue 3 Pages 410-419
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.410
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    Three patients with generalized psoriasis, a patient with chronic eczematous dermatitis and a patient with exfoliative dermatitis were treated with 0.1% triamcinolone acetonide ointment (Ledercort oint.), 20g/day, (20mg. triamcinolone acetonide) under ODT. The serum 11-OHCS and urinary 17-OHCS levels were estimated every day. Eosinophil counts and blood glucose levels were also determined. The serum 11-OHCS and urinary 17-OHCS levels were slightly lowered or unchanged in all cases during observation. The phenomenon of inhibition of adrenocortical function was slight and the levels of serum 11-OHCS were limited in normal range. A decreasing tendency of eosinophil counts and increasing of blood glucose levels were observed in one case respectively. ODT with 0.1% triamcinolone acetonide ointment showed clinical usefulness. It seems reasonable to conclude from the above resusts that the patient with chronic skin disease, e. g. psoriasis, would be better treated with this ointment in external application.
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  • Experimental Study on Ampicillin Trihydrate Aquous Suspension
    Michiyaus ARIYOSHI, Tadahiko MATSUMOTO
    1975 Volume 37 Issue 3 Pages 420-425
    Published: June 01, 1975
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.37.420
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    Experimental studies for comparative purposes were carried out with AB-PC (aminobenzyl-penicillin) sodium, hitherto used as an intramuscular penicillin, and ampicillin trihydrate, a new aqueous ampicillin suspension for intramuscular use, and the results obtained were as outlined below:
    (1) Ampicillin trihydrate was found to maintain higher blood and dermal levels than ampicillin sodium. Both displayed a high degree of movement from the blood to the skin.
    (2) Used against syphilis experimentally induced in rabbits, the superior efficacy of ampicillin trihydrate as compared with that of ampicillin sodium was confirmed in terms of titer, immobilization and elimination of Treponema pallidum, and curative changes in foci.
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Review
Statistical Study
Therapy
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