The literature on dermatophytosis and its causative fungi in Kyushu district during a 45-year period (1924∼1968) has been reviewed. In tinea capitis, Trichophyton ferrugineum was the most common species isolating in 67% of cases; followed by T. glabrum, 24%; T. violaceum, 5.1%: T. gypseum (asteroides), 1.3%; T. rubrum, 0.3%; Microsporum gypseum, 0.2%, and T. coccineum, 0.7% respectively. However, not a single strain of T. coccineum has been isolated since 1950, and the incidence of T. ferrugineum in cases with tinea capitis has markedly decreased after the war. In southern part of Kyushu and Okinawa, T. glabrum and T. violaceum prevail over T. ferrugineum, showing geographical variation of the agents of tinea capitis. In tinea pedis, tinea unguium, tinea cruris, and tinea corporis, the most commonly isolated organism was T. rubrum, 71%; followed by T. interdigitale, 21%; T. gypseum (asteroides), 2.0%; Epidermophyton floccosum, 1.3%; T. ferrugineum, 1.2%; T. pedis, 0.8%; M. gypseum, 0.5%; T. glabrum, 0.2%; T. coccineum, 0.18%, and T. violaceum, 0.12%. The incidence of T. rubrum in cases with tinea pedis has been increasing.

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One of the disadvantages of the occlusive dressing technique is its foul odor because of bacteria cultured under the dressing. Attempts were to minimize this odor and it was found that the dispersion of aluminium potassium sulfate prior to the application of corticoid ointment is no growth of bacterial colonies in spite of application of corticoid ointment under the dressing.

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A 27-year-old pregnant woman (7 months) with impetigo herpetiformis has been reported. The first pregnancy and delivery ran normal course. One month ago miliary reddish papules appeared on the axillae and spread to the trunk and extremities with continous or remittent fever, resulting numerous pustules in a circinate manner upon an inflammatory base. The mucous membrane was also affected. The spongiform pustule of Kogoj was demonstrated by a biopsy. A large doses of oral corticoids, vitamin B₁₂, antibiotics and an artificial abortion showed almost no therapeutic effect.

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A case of dysgammaglobulinemia type I was reported. The diagnosis was established by quantitative measurement of the serum immune globulins of the patient, male infant, fifteen months old: IgG 60mg/dl, IgA ?? 0 and IgM 85mg/dl. The clinical features consisted of recurrent infections of respiratory tract, tonsillitis and abscesses of skin soon after birth. The cervical, axillary and inguinal lymph nodes were apparently enlarged. Plasma cells were not present in biopsy specimens of lymph nodes or bone marrow smears. The biopsy specimen showed indistinct and scanty lymphoid follicles. Serum total protein was 5.8mg/dl; serum paper electrophoresis showed Al 59.2%, α₁-Gl 7.4%, α₂-Gl 22.2%, β-Gl 10.4% and γ-Gl 0.7%.

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A case of Melkersson-Rosenthal syndrome was reported. The patient was 18-year-old man, noted enlargement of his lips and plicated tongue 8 years previously. At age 1, he had polyomyelitis anterior acuta and he had had paralysis of the right facial nerve. There is no granulomatous reaction of the lip microscopically. A review of this disease was performed.

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215 nonsyphilitic sera and 105 syphilitic sera were examined by TPHA test (to use as antigen formalin treated tanned sheep red blood cells sensitized by T. P. Nichols strain and testing sera absorbed with T. P. Reiter strain and etc.,).
Results:
1) On the nonsyphilitic sera 195 gave negative results to both of STS and TPHA, 6 gave positive results to TPHA and negative to STS, 14 gave negative results to TPHA and positive to STS. Then these were regarded as BFP, coinciding with results to FTA-200.
2) On the syphilitic sera
101 gave positive results to both of STS and TPHA. The reactivity to TPHA has been persistent after the antiluetic treatment. The sensitivity and spicificity of TPHA on syphilis might be satis-factory as that of FTA. Then the advantage of TPHA might be the stable graded agglutination figure on the hollow plastic plate for the test.

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Thirty-nine patients with superficial dermatomycoses were treated with a new antifungal solution containing 3-(p-methylbenzylideneamino)-4-phenyl-thiazoline-2-thione and the excellent results were obtained. In cases with tinea cruris and tinea macrovesiculosa, the fungus disappeared from the lesion in two or three weeks after the initiation of the treatment. Side effects were minimum.

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The therapeutic effect of antifungal agent, 3-(p-methylbenzylideneamino)-4-phenylthiazoline-2-thione referred as TBK hereafter, was clinically tested on some kinds of tinea. TBK preparations, in a form of carbowax ointment containing one (TBK I) or two (TBK II) percent, was applied. Of 30 subjects tested, there were 19 Tinea cruris, 10 T. interdigitalis and 14 T. pedis. TBK I was applied in 10 subjects and TBK II in 7. In the rest, both preparations were used—different lesions of same individual—for comparison of efficacy according to the concentrations. The therapeutic effects of TBK I and TBK II were 70% and 89% for T. cruris, 71% and 100% for T. interdigitalis, and 17% and 33% for T. pedis, respectively. As to side effects, contact dermatitis was observed only in a patient with T. cruris treated by TBK II.

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The following results were obtained by our fundamental and clinical studies of a new antifungal agent, 3-(p-methylbenzylideneamino)-4-phenylthiazoline-2-thione (TBK).
1) The antifungal effect in vitro was found at the concentration of 3.12γ/cc against trichophyton mentagrophytes, 1.5γ/cc against trichophyton rubrum, and over 100γ/cc against candida albicans.
2) The healing rate of experimental trichophytia was 100 percent.
3) Clinically TBK-I solution (1%) and TBK-II solution (2%) were applied to 7 cases with tinea cruris and 17 cases with tinea pedis.
TBK-I solution was very effective in 11 cases, effective in 7 cases, slightly effective in 2 cases, and ineffective in 4 cases.
TBK-II solution was very effective in 12 cases, effective in 5 cases, slightly effective in 2 cases, and ineffective in 5 cases.
4) Side effects were observed in 2 cases.

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Following results were obtained by our fundamental and clinical studies of Angimn.
1) Anginin was clinically applied to 52 cases of various skin diseases. Of these 52 cases, effective therapeutic results were obtained in 9 of 13 cases of urticaria, 6 of 10 chilblain cases, 2 of 4 cases of erythema exsudativum multiforme, 1 of 4 cases of erythema nodosum, 2 of 3 cases of chronic venous insufficiency and 4 of 17 cases of the other various skin diseases.
2) Though 8 cases of 52 complained the gastro-intestinal disturbances, other sevre side effect was not observed.
3) Urticaria, chilblain and a certain stage of chronic venous insufficiency were considered as to be the indication of Anginin therapy in dermatology.
4) The efficacy of Anginin for recover of skin temperatur from cold was examined. In healthy person this drug had no influence.
In cases of urticaria and chilblain the effect was observed, while one cases of scleroderma diffusum showed the delayed recover of skin temperatur before and after therapy.

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