The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 35, Issue 6
Displaying 1-18 of 18 articles from this issue
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Case Reports
  • Pustulosis Palmaris et Plantaris
    —A Case Associated with Chronic Rheumatoid Arthritis Which Responded to Tonsillectomy—
    Tomomichi ONO, Yuichi NAGAHIRO
    1973 Volume 35 Issue 6 Pages 679-684
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.679
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    Report was made of pustulosis palmaris et plantaris associated with chronic rheumatoid arthritis appearing in a 61 year-old woman. In both disorders, focal infection has been considered to be an etiologic factor. Tonsillectomy was performed in this patient of these two disorders. A review of the literature was made on the relationships between pustulosis palmaris et plantaris and chronic rheumatoid arthritis, and between tonsillitis and these two disorders.
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  • Therapy of Hemangioma-Thrombocytopenia Syndrome
    Katsuro OYAMA, Shohei INOUE, Hiroshi SAKANASHI, Hiroshi SUDO
    1973 Volume 35 Issue 6 Pages 685-693
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.685
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    We reported three cases of hemangioma-thrombocytopenia syndrome and discussed the therapy of this syndrome. The main treatments of this syndrome are radiation therapy and general administration of corticosteroid, however the latter therapy shoud be reconsidered because of its doubtful effect and side effects. From our experience, we prefer electron beam therapy as the first choice for this syndrome.
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  • A Case of Chronic PCB-Intoxication
    Seichiro SAGAMI, Shojiro KAMATA, Mitsu YOSHIDA
    1973 Volume 35 Issue 6 Pages 694-701
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.694
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    A 33-year-old house-wife with dissemination of pigmented macules was first seen in July, 1972. Six years before her first visit, she had worked for 6 years in a battery-factory, at where, polychlorobiphenyl (PCB) was demonstrated at the concentration of 0.01∼0.05 ppm in air, and 0.09∼0.59 ppm in the laborers’ sera. Clinically, the face, back and extensor aspect of upper extremity were disseminated by blackish pigmented macules with dilated follicular pores, induration and/or pustule. Nail plates and shoulders and iliacal regions were also diffusely pigmented. Hypersweating was one of complaints. Histologically, there were perivascular cell infiltration throughout the dermis, degeneration of fatt cell, arrector muscle-cell and hair-bulb. Melanophages were also encountered at the dermo-epidermal junction. Chemically, high concentration of PCB in the blood (0.08∼0.128 ppm) and in the abdominal fatty tissue (42 ppm) was found as well as high level of the serum-triglyceride (148∼350 mg/dl) and alkali phosphatase (6.2∼8.0 unit), low urinary excretion of 17KS (2.2∼6.4 mg/day). Other laboratoy examinations were all within normal limits.
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  • Vitamin E and Porphyria Cutanea Tarda
    Masaru YASUDA, Toshiharu MOTOMATSU
    1973 Volume 35 Issue 6 Pages 702-706
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.702
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    Serum vitamin E level in twenty patients was determined by colorimetric method. In a 49-year-old male with porphyria cutanea tarda, serum vitamin E level was the lowest. After he was given d1-α-tocopherylacetate (Juvela, Eisai Co., Japan) 300mg/day for a period of forty days, we found clinical improvement that paralleled the rise in serum vitamin E, but the urinary excretion of uroporphyrin and coproporphyrin remained unchanged.
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Clinical Study
  • Skin Manifestations and Diabetes Mellitus
    I. Statistic Studies on the Skin Manifestations of Diabetes and Clinical Prediabetes
    Hirokazu YASUNO, Kiyoshi KAGAMI, Takeshi YANO
    1973 Volume 35 Issue 6 Pages 707-715
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.707
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    The authors discussed statistically skin manifestations and their relationship between each skin manifestations in the cases of diabetes and clinical prediabetes. The summaries are as follows:
    1. Diabetic patients have a high incidence in the following skin manifestations; pyogenic skin infections, fungus infections, solar dermatitis, seborrheic dermatitis, chronic eczema, xanthoma and pruritus cutaneus.
    2. The patients of clinical prediabetes have a high incidence in the following skin manifestations; seborrheic dermatitis, rosacea, pustulosis palmaris et plantaris, psoriasis vulgaris, erythema nodosum, chronic urticaria, herpes simplex and pyogenic skin infections.
    3. Hyperglycemia or abnormal glucose metabolism is considered as an important factor in chronic eczema and fungus infections.
    4. The diabetic patients of psoriasis vulgaris and pustulosis palmaris et plantaris may be influenced by the some pathological factors rather than abnormal glucose metabolism.
    5. The diabetic patients of pyogenic skin infections and pruritus cutaneus may be influenced by various abnormal metabolic conditions.
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  • A Study on the Eczematous and Dermatitis-Like Lesions Localized on the Face of Adult
    II. Patch Test Study
    Tsutomu SHINO
    1973 Volume 35 Issue 6 Pages 716-721
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.716
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    To study the relationship between eczematous, dermatitis like-lesions localized on the face of adult and cosmetics, patch test studies were carried out on 506 patients. The results obtained were as follows. Positive percentage value of the patch test was 67% in eczematous eruptions (include contact dermatitis), 61% in seborrhoic dermatitis and 65% in melanosis Riehl, but acne vulgaris showed 52% and 46% in chloasma. Allergic reaction predominated in contact dermatitis, but in other diseases, strong primary irritant reaction which continues over 24 hours was dominant. Use was made of questionaire investigation, in 81% of the patients, the lesions improved by stopping the use of patch test positive cosmetics. Primary irritant reaction is as significant as allergic reaction in patch test of cosmetics.
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  • Effect of Cephalexin on Virulent Treponema pallidum
    Hiromu KODA, Michiyasu ARIYOSHI, Tatsuro SUZUKI, Harukuni URABE, Yukio ...
    1973 Volume 35 Issue 6 Pages 722-730
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.722
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    Effect of cephalexin (CEX) on virulent Treponema pallidum Nichols strain was investigated. The results were summarized as follows:
    1) The VDRL titer of 7 rabbits were determined following intratesticular infection with T. pallidum and after oral administration of CEX 80mg per kg per day for 2, 5 or 10 days. Those animal treated with CEX for 5 days or 10 days exhibited rapid decrease of VDRL titer, but for 2 days only a few decrease.
    2) Syphilitic orchitis which occurred following infection disappeared after 10 days from the beginning of the treatment with CEX. T. pallidum from the lesion were immobilized after 2 days treatment.
    3) To investigate the direct effect of CEX on T. pallidum in vitro T. pallidum from the syphilitic orchitis were incubtead in medium containing various amount of CEX for 17 hours. It was found that 100% T. pallidum were immobilized by the CEX concentration at 0.002 μg/ml, 70% of T. pallidum were immobilized at 0.001 μg/ml CEX.
    4) Five patients with ulcus durum, ulcus mixtum, congenital syphilis or syphilis latens were treated with CEX. Healing of the lesions and the decrease of antibody titer were observed in all patients.
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  • The Effect of Topical Vitamin A Acid on Darier’s Disease
    Takae HIRONE, Norio OTSUKI, Yoichi NAKAMURA
    1973 Volume 35 Issue 6 Pages 731-742
    Published: December 01, 1973
    Released on J-STAGE: March 24, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.35.731
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    Clinical, histological and electron-microscopic studies on the effect of topical vitamin A acid on Darier’s disease were performed. The ointment used was 0.1 % vitamin A acid cold cream. Complete clinical remission of the lesions was obtained after 15 days of daily application without occlusion, or after 10 to 14 days of daily application under occlusion. Local remission in the treated areas persisted about 3 to 5 months after cessation of the treatment. Biopsies from the treated areas showed complete disappearance of the characteristic changes of Darier’s disease. Electron microscopy revealed that after 10 days of daily application under occlusion tonofilaments were decreased and both membrane-coating granules and keratohyalin granules were increased, and that at 3 months after cessation of topical application under occlusion keratinocytes in all layers of the epidermis showed normal appearance and horny cells showed normal keratin pattern.
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