The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 31, Issue 3
Displaying 1-14 of 14 articles from this issue
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Photograph
Special Article
Symposium—Contact Dermatitis—
  • Preface
    Kihei TANIOKU
    1969 Volume 31 Issue 3 Pages 237-239
    Published: June 01, 1969
    Released on J-STAGE: March 26, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.31.237
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  • Contact Dermatitis and the Regional Lymph Nodes
    Sinichi FUJITA
    1969 Volume 31 Issue 3 Pages 240-246
    Published: June 01, 1969
    Released on J-STAGE: March 26, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.31.240
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    To know a part of changes of regional lymph nodes in contact dermatitis, we performed the following experiments. Experimental animals; Albino guinea pigs weighing 350 to 450g. Sensitization; Guinea pigs were sensitized by applying 3% 1-chloro-2,4-dinitrobenzene ethanol solution on the inguinal region. 8gtt. on the 1st day and then the dosis were increased by one drop every day to reach 15gtt. after seven days. The inguinal lymph nodes of these guinea pigs were exstirpated at varied time up to 36th day. The weight, content of RNA-P and DNA-P and histological changes of these nodes were examined. The weight of these nodes gradually increased, arriving at maximum on 13th day. The increase in nucleic acids were found to parallel to the increase in weight of the nodes. Slightly higher increasing rate of RNA-P than DNA-P was seen on 4th to 8th days. Methylgreen-pyronine stained sections of the nodes revealed the increase of the large pyroninophilic cells at that ti me. Pasive transfer was also tried with the nodes.
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  • Observation of the Leucocyte, Lymph Node and Permeability on Contact Dermatitis.
    Jyoji JIDOI
    1969 Volume 31 Issue 3 Pages 247-254
    Published: June 01, 1969
    Released on J-STAGE: March 26, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.31.247
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    Ten mg of cyclophosphamide were injected intraperitoneally to guinea pigs for five days and the leucocyte, lymph node and permeability on the course were observed. At seventh day the leucocyte in blood was decreased to about one thousand per ml and recovered to normal at thirteenth day. On pathological findings in lymph node the germinal center was almost disappeared and the lymphcyte decreased remarkably at fifth day and recovered at fifteenth day. DNCB dermatitis on guinea pigs was not developed when sensitization was done at the same or five days before of cyclophosphamide injection and the severe dermatitis was observed on the cases of sensitization were done immediately after injection. The capillary permeability on DNCB dermatitis in guinea pigs began at six hours and reached to maximum at ten to twenty hours and gradually decreased. The permeability factor in extract from DNCB dermatitis skin might be peptide and checked in vivo and found it on the same area of ninhydrin reaction positive.
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  • Investigation on Blood Fibrinolytic Activity in Contact Dermatitis
    Masaaki TASHIRO, Sumio KOURA, Kunihiko SARUWATARI
    1969 Volume 31 Issue 3 Pages 255-263
    Published: June 01, 1969
    Released on J-STAGE: March 26, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.31.255
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    We made some observations of blood fibrinolytic activity in clinical or experimental contact dermatitis. Results obtained are as follows: Elevated fibrinolytic activity was observed in contact dermatitis, especially in that of exsudative manifestations of the skin or in several causes of contact dermatitis. In spite of disappearance of skin manifestation, high fibrinolytic activity was recognized in many cases. Elevated fibrinolytic activity was observed in experimental dermatitis by croton oil or DNCB, too. And tissue activator in inflammatory skin was higher than another skin.
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  • Substances Responsible for Contact Dermatitis and the Conceptional Diagram of Organic Compounds of Fujita
    Tatsuo FUJIKI
    1969 Volume 31 Issue 3 Pages 264-278
    Published: June 01, 1969
    Released on J-STAGE: March 26, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.31.264
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    Most substances responsible for contact dermatitis are composed of organic compounds. However there is no rule governing the relationship between the chemical formulae of dermatitis-producing substances and mechanisms of contact dermatitis. But there is no denying that there is a close relationship in this respect. In this report, the conceptional diagram of organic compounds of Dr. A. Fujiia was tested. Many substances, known chemically and responsible for contact dermatitis were located in the diagram. The author proposed the photo-sensitizing substance area, carcinogenic substance area, cell-damaging substance area, organic active substance area, inorganic active substance area, the area of substances which have organic and inorganic properties and the border line of sensitizing substances. The substances respobsible for difolatan dermatitis were located in the diagram and the relationship between the location of these substances in the diagram and irritation dermatitis, photo-toxic dermatitis and photo-allergic dermatitis was analyzed. These substances were located in agreement with the proposed areas in the diagram.
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Case Reports
  • Pyoderma Gangrenosum associated with so called Pulseless Disease
    Manabu YAMASAKI, Masaru YASUDA, Toru NOZU, Norihiro YASUKAWA
    1969 Volume 31 Issue 3 Pages 279-295
    Published: June 01, 1969
    Released on J-STAGE: March 26, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.31.279
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    A 13-year-old girl having pyoderma gangrenosum was reported, which associated with aortitis syndrome. Clinico-pathological analysis of 7 cases associated with so called pulsess disease in Japan suggests that infection and immunologic deficient state shuld be playing some roles on its pathomechanism as being Schwartzman phenomenon or allergic rection. t-AMCHA was effective in the own case and it may suggest that plasmin is the important chemical mediator in this disease.
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Clinical Study
  • Clinical Studies on Hydrogen Ion Concentration on the Surface of Normal Human Skin
    Tadashi TAURA
    1969 Volume 31 Issue 3 Pages 296-314
    Published: June 01, 1969
    Released on J-STAGE: March 26, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.31.296
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    Through use of a single glass electrode, the surface of normal skin was measured for pH value, and statistical observations were made. The results are as follows.
    1) The pH value of normal skin was 4.87 inmales and 5.05 in females showing an increase at high-teenage in females and after age 50 in males. As to the difference in value by the region, the upper arm showed higher value than the forearm, and the exterior portion than the interior portion. Many female cases showed high value in the forehead. The value was high in winter and low in summer showing a big variation between spring-summer period and fall-winter period.
    2) In neonates, the pH value was high immediately after birth but remarkably decreased around the 4th day. The inguinal region maintained high value with little variation due to lapse of days. The pH value in neonates seemed to be affected by the absorption and decomposition of vernix caseosa and amniotic fluid, and, in the inguinal region, by the contaminationby urine.
    3) The value in the 4th interdigital region of foot was much higher than that in the 1st interdigital region. Moreover, high value was more frequent in the cases with the past history of trichophytosis. Hence, it was presumed that the interdigital pH value is related to the onset of interdigital trichophytosis.
    4) The scrotum indicated higher pH value exceeding 7.0 in some cases and wider range of variation as compared to the inguinal region. This is considered to be due to the peculiar anatomical condition of the scrotum.
    5) In females, the pH value decreased during the period of menstruation and the period of variation was stable.
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