The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
Volume 71, Issue 3
Displaying 1-15 of 15 articles from this issue
Color Atlas
Mini Review
Clinical Case Reports
  • Kazuo MIZUMOTO, Hiroyuki NIHARA, Eishin MORITA, Naoki HARUTA
    2009 Volume 71 Issue 3 Pages 260-264
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    A woman in her seventies was diagnosed with a venous stasis ulcer with a varicose vein. Although she underwent venous stripping, her ulcer was expanding. We diagnosed venous stasis ulcer due to insufficient perforating veins with a Duplex scan. We performed subfascial endoscopic perforator vein surgery and debridement. Fine granulation was observed on the ulcer, and a free mesh skin graft was performed. At 35 days after the operation, the ulcer was completely epithelialized. At 3 months after discharge, no further ulcer had developed on her leg.
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  • Shujiro HAYASHI, Youichiro HAMASAKI, Yohei KITAMURA, Akihiro SOTOME, H ...
    2009 Volume 71 Issue 3 Pages 265-268
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    We report here a case of systemic sclerosis associated with esophageal carcinoma. A 78-year-old man noticed skin scleroses on his finger and forearm in November 1996. The following year, he visited our department. He was diagnosed with systemic sclerosis (diffuse type) by the clinical and laboratory findings, as well as the pathological findings of the skin biopsy. He was treated for skin sclerosis with topical PUVA and an initial dose of 30 mg/day of oral prednisolone. Prednisolone was decreased to 5mg/day two months later. Subsequently, he noticed dysphagia in April 2007, and esophagogastroduodenoscopy (EGD) was then performed. The inferior part of the esophagus had a white lesion which was diagnosed as esophageal carcinoma (carcinosarcoma) by biopsy with EGD. The patient then underwent esophagogastrectomy on July 2007. However, he subsequently died due to deterioration of postoperative course.
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  • Kosuke MOCHIDA, Dai OGATA, Keitaro FUKUDA, Teruki KATAOKA, Jun NAKAURA ...
    2009 Volume 71 Issue 3 Pages 269-274
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    Case 1. The patient was a 69-year-old female, who had a black nodule at the dental line. An excisional biopsy specimen from the lesion revealed malignant melanoma. She underwent an abdominoperineal resection and postoperatively received 5 courses of DAV (DTIC, ACNU,and VCR) therapy. The patient has been disease-free for 3 years and 5 months after the operation without any signs of recurrence. Case 2. The patient was a 74-year-old male, who had previously undergone local resection of an anorectal tumor with anal bleeding, and was diagnosed with anorectal malignant melanoma at another hospital before admission into our institution. One year and two months after the first resection, local recurrence was detected at the rectum, and he underwent an abdominoperineal resection in the same hospital. Two months later, he presented with multiple metastatic lesions (stomach, rectum and celiac and pelvic lymph nodes) and was admitted to our hospital. Here, the patient received DAC-Tam (DTIC, ACNU, CDDP and Tamoxifen) therapy. During 5 courses of the chemotherapy, the gastric lesion was significantly reduced in size and the rectal lesion became stable. Thus, although he was able to intake orally, the chemotherapy was useful from the viewpoint of QOL. Subsequently, multiple skin metastases developed and CDV (CDDP, DTIC and VDS) combined chemotherapy was initiated. After the second chemotherapy course, brain metastasis appeared and the patient died of melanoma 16 months after the start of chemotherapy and 33 months after the initial diagnosis of anorectal malignant melanoma.
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  • Akemi OHNISHI, Yuichi YOSHIDA, Osamu YAMAMOTO, Kazuhiko HAYASHI
    2009 Volume 71 Issue 3 Pages 275-277
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    A 69-year-old woman developed erythema on the inside of her left femoral in March 2006. She visited a dermatology clinic and was diagnosed with erysipelas. However, since response to the therapy was poor, she was referred to our hospital. Physical examination revealed erythema and painful swelling from the pubic region to the left femoral, and an erosion 1cm in diameter on the anterior surface of the left femoral. Laboratory findings revealed leukopenia. Histopathologically, medium and large irregularly-shaped lymphocytes were invading into the subcutaneous tissue. Immunohistochemically, the tumor cells were positive for CD3, CD8, CD45RO, and granzyme B, but were negative for CD4, CD5, CD10, CD20, CD23, CD56, CD79α, and myeloperoxidase. A diagnosis of subcutaneous panniculitis-like T-cell lymphoma was made, and as a consequence, she was treated with systemic chemotherapy (Hyper-CAVD). However, only 21 days after the initial visit, she died from sepsis with multiple metastasis. An autopsy revealed complication of hemophagocytic syndrome (HPS).
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  • Chiaki BABA, Takurou KANEKURA, Souji SANE
    2009 Volume 71 Issue 3 Pages 278-280
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    A 69-year-old male patient noticed the enlargement of the areola of the right mammary gland in February of 2005, that was gradually getting larger. He visited our department in December 2006. Skin biopsy from the mammary areola showed papillotubular carcinoma. Computed tomography of the chest demonstrated a subcutaneous nodule under his right mammary areola and enlargement of the right axillary lymph nodes, suspected to be metastasis. A modified radical mastectomy and axillary lymphadenectomy were performed. Though male breast cancer is a comparatively rare disease, the most typical clinical feature of male breast cancer is a mass of the mammary areola and the patient may consult a dermatologist. We report a case of male breast cancer with a review of the of current literature.
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  • Sugiko NOAMI, Reiko HORIGOME, Kazuhiko MATSUMOTO, Minoru TAKATA
    2009 Volume 71 Issue 3 Pages 281-284
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    A 14-year-old Japanese girl presented with nodules and papules on her chest. The biopsy from the chest skin showed non-caseating epithelioid cell granulomas associated with mixed inflammatory infiltrate consisting of lymphocytes, neutrophils and eosinophils. Two years later, she noticed erythema on the scalp, hair loss and cervical lymph node swelling. Cultures from the skin tested negative for Mycobacterium. The cervical lymph node was excised and histopathology of the cervical lymph node showed non-caseating epithelioid cell granulomas. Mycobacterium tuberculosis was finally isolated from the third skin biopsy specimen. We diagnosed the lesions as lupus vulgaris. The skin lesions cleared after 8 months of oral administration of rifampicin and isoniazid.
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  • Shinsuke YASUKAWA, Taizo TAKESHITA, Kiyoshi HAYASHIDA, Kozo NAITO, Fum ...
    2009 Volume 71 Issue 3 Pages 285-288
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    A 26-year-old woman was admitted to our hospital for treatment of fever of unknown origin. She had tender erythematous nodules on her fingertips, and nontender erythematous nodules on her palms and soles. Endocardiography showed oscillating intercardiac vegetation, and blood culture tested positive for a methicillin-resistant Staphylococcus Aureus. Thus, the diagnosis of infectious endocarditis was made, and resection of vegetation was performed. Most of the nodules disappeared after treatment by operation and antibiotics. The tender erythematous nodules on her fingertips were believed to be Osler's nodes and the nontender erythematous nodules on her palms and soles were compatible with Janeway's lesion.
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  • Hanako SEKIYAMA, Hidekazu SHINODA, Katsutaro NISHIMOTO
    2009 Volume 71 Issue 3 Pages 289-293
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    We report eight cases of tinea corporis due to Trichophyton tonsurans with fungal parasitism of the hair sampled from patients' skin rashes. The patients were junior and senior high school students with ages varying between 14 and 16 years old. The male : female ratio was 6 : 2. We sampled the hair from the patients' eruptions at the first examination and screened them for parasitic fungi. Endothrix as well as hair root-parasitic fungi were found in the culture from five patients who had previously received treatment with topical antifungal medication before our first examination. This finding implies that topical antifungal medication must be combined with oral agents in order to eradicate the fungi completely. Monotherapy with topical drugs can alleviate the skin rash, but we cannot exclude the possibility that the surviving fungi could transform the patient into a carrier, which could lead to relapse and spreading of the infection. Therefore, we conclude that, upon diagnosis of tinea corporis, sampling of the lesion site hair and KOH microscopic examination should also be performed, in addition to the usual scale inspection.
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Review
Statistics
  • Motoko MIYACHI, Yumiko KUBOTA, Miki MATSUO, Osamu TANIGAWA, Juichiro N ...
    2009 Volume 71 Issue 3 Pages 306-311
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    We experienced a total of 25 cases (male : female = 8 : 17) of scabies from June 2003 to September 2007 at Nishifukuoka Hospital and studied the clinical features in these patients. The mean age was 81.7 years. There were 6 patients with diabetes and hypertention, 7 patients with dementia, 5 patients with cerebral infarction, and 3 patients with cancer and myocardial infarction as past illnesses. The scabies rashes varied from involving one part of the body to the whole body. Scabies was significantly more prevalent in winter compared to summer. Mites were found more frequently in the toes and axilla. We suggest that 8 patients contracted scabies in a hospital, 8 patients in a nursing home, 2 patients at home, and 1 patient from a friend. We treated the patients with ivermectin or crotamiton ointment and benzoyl benzoate lotion. We did not observe any side effects of the ivermectin. One patient relapsed one and a half months after the end of treatment. Elderly patients with xerotic dermatitis or tinea unguium should be examined with a suspicion of scabies.
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Therapy
  • Hidetoshi TAKAHASHI, Hajime IIZUKA, Toshihiro ITO, Osamu FUKUCHI, Nao ...
    2009 Volume 71 Issue 3 Pages 312-320
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    The efficacy and safety of maxacalcitol lotion (Oxarol® Lotion ; 25μg/g) were evaluated in 54 patients with psoriasis vulgaris after topical application of the lotion to their hair-covered scalp, trunk, extremities, and face. The score of each skin symptom (erythema, infiltration/thickening, and scales) and the total of these scores began to decrease significantly from baseline to two weeks after treatment began (P<0.001, Wilcoxon signed-rank test). No abnormal changes in serum calcium, serum creatinine, or blood urea nitrogen concentrations were observed, and no local or systemic adverse reactions were noted. In terms of global safety, the drug was rated “free of safety problems” in 92.5% of cases, and “almost free of problems” in 7.5 % of cases. In response to a survey conducted in some of the patients at the end of the study, 81.0% stated that they felt “no stress” or “almost no stress” after the topical application of maxacalcitol lotion, and 95.3% stated that they had little or no feeling that the application of the lotion took much time. The results suggest that maxacalcitol lotion is highly effective when applied topically to the hair-covered scalp and to more extensive parts of the body (trunk, extremities, and face), and is unlikely to cause hypercalcemia (indicated by elevated serum calcium) or acute renal failure. We conclude that maxacalcitol lotion, which is currently used topically (primarily for the hair-covered scalp), is likely to be effective when applied to more extensive areas of the body (trunk, extremities, and face), and may be a useful alternative in the treatment of patients in whom ointment is difficult to apply (e.g., patients with low compliance or a low quality of life).
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  • Patient Assessment with a Self-administered Questionnaire
    Masutaka FURUE
    2009 Volume 71 Issue 3 Pages 321-327
    Published: June 01, 2009
    Released on J-STAGE: July 16, 2009
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    The efficacy of ebastine (Ebastel®), a second-generation antihistamine, for the treatment of pruritic skin disease was assessed by performing a questionnaire survey. Twenty-four patients who had atopic dermatitis and primarily presented with pruritus were treated with ebastine (10 mg once daily) for 4 weeks. Before and after the 4-week treatment period, the patients were asked to assess their pruritic symptoms by using a self-administered questionnaire. The questionnaire covered various aspects and the questions were randomly sorted to minimize interactions that could potentially bias the answers to successive questions. Four weeks of treatment with ebastine significantly reduced the frequency, severity, and intensity (VAS score) of pruritus, confirming that this drug effectively suppresses pruritus. Ebastine treatment also significantly relieved nocturnal pruritus that had caused sleep disturbance and thus improved daily activities, resulting in overall improvement of the patients' quality of life that had been impaired by pruritus. Compared with the response to prior treatment, the antipruritic effect of ebastine appeared more rapidly and persisted for a comparable duration after each dose. These results indicate that ebastine has a rapid and durable antipruritic effect, while causing fewer adverse events such as drowsiness, suggesting that this second-generation antihistamine may be a more satisfactory antipruritic agent for patients.
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