The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 45, Issue 6
Displaying 1-20 of 20 articles from this issue
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Color Atlas
Mini Review
Clinical Case Reports
  • Superficial Spreading Melanoma
    —Report of a Case and an Electron Microscopic Study on the Role of Melanin Pigment for the Variation of Macroscopic Color of Melanomas—
    Masayuki NISHIMURA, Kimihiko MIHARA, Hiromu KOHDA
    1983 Volume 45 Issue 6 Pages 958-964
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.958
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    We report the case of a 62-year-old woman with superficial spreading melanoma on her left thigh. The melanosomes in the cytoplasm of the tumor cells were studied electron microscopically. Although a small number of typical eumelanosomes were seen, there was a large number of altered melanosomes of spheroid shape and which contained vesicular, spiral microtubular and/or fragmented regular fibrillar matrices instead of parallel fibrillar structures. These melanosomes showed various amounts of diffuse granular melanin deposition. Based on recent advances in melanin chemistry and ultrastructural characteristics of eu- and pheo-melanosomes, these melanosomes were considered to be pheomelanosomes and/or mixed types of eu- and pheo-melanosomes. We speculate that the type and amount of melanin pigment in tumor cells might be responsible for variations in the macroscopic color of melanomas.
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  • Comparative Observation of the Reactively Infiltrating Cells Between Two Lesions in a Case of Senile Keratosis Changing into Squamous Cell Carcinoma
    —An Immunohistological Study Using Monoclonal Antibodies—
    Masayoshi JOHNO, Yasuko KOJOH, Toshiro KAGESHITA, Yukihiro OKUMURA, Hi ...
    1983 Volume 45 Issue 6 Pages 965-971
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.965
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    In situ immunological phenotyping of the lymphocytes and macrophages within the tumor nests and in these stroma was performed in a case of senile keratosis (SK) changing into squamous cell carcinoma (SCC). The hypersensitive peroxidase enzyme antibody method using monoclonal antibodies specific for T-cells, for killer and suppressor T-cells, for helper and inducer T-cells, or for Langerhans cells was used. The results of our studies may be summarized in the following three points. 1) The cells infiltrating into the dermis of SK and SCC were lymphocytes and almost all were T lymphocytes. 2) The Leu2+ cell/Leu3+ cell ratio of the area of SK was higher than that in the normal peripheral blood, but this finding was not observed in the area of SCC. 3) It was confirmed that Leu2+ cells infiltrate into and just below the nest of SK, while there were no such findings in the area of SCC. These results suggest that there is/are antigen(s) specific to SK reactable to Leu2+ cells and that is treated with Langerhans cells.
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  • A Case of Eosinophilic Pustular Folliculitis, Developed in the Course of Treatment for Steroid Dermatosis
    Eiko MANO, Yusei ITOH
    1983 Volume 45 Issue 6 Pages 972-975
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.972
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    In a 50-year-old man steroid dermatosis developed after using mainly betamethasone valerate cream for over five years. In the course of the treatment for steroid dermatosis, folliculopustular and infiltrative lesions appeared on his eyebrow and lower jaw. On histological examination of the biopsy specimens of the lesion, typical eosinophilic pustular folliculitis (EPF) was revealed. The skin lesions of EPF disappeared nine weeks after complete discontinuation of the use of steroids for topical application.
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  • A Case of Eosinophilic Fasciitis
    Kazuhiro KATAOKA, Sanae IKEDA, Mie TAKATA, Masaaki EGAWA, Hirofumi NAK ...
    1983 Volume 45 Issue 6 Pages 976-981
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.976
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    A 49-year-old woman had diffuse sclerotic cutaneous lesions and a few coin-sized indurated erythematous eruptions on her legs. Laboratory data showed circulating eosinophilia, elevated sedimentation rates and hypergammaglobulinemia. Rheumatoid factor, LE cells, antinuclear antibodies and complement level were negative or normal. Biopsies obtained from skin lesions of her left leg revealed conspicuous thickening of the fascia and infiltrations of lymphocytes, eosinophils, histiocytes and neutrophils in the dermis. Lymphocytic infiltration was also observed in the muscle tissue of the lesion. X-ray of the leg bones showed a hypertrophic change in the periosteum. The patient had a thyroid nodular tumor which histologically proved to be papillary carcinoma.
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  • Two Cases of Sweet’s Syndrome (Acute Febril Neutrophilic Dermatosis)
    Kagari ASHIZAWA, [in Japanese], [in Japanese], [in Japanese]
    1983 Volume 45 Issue 6 Pages 982-986
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.982
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    Case 1: A 46-year-old woman. Case 2: A 65-year-old woman. In both patients there was a slightly elevated erythema with infiltration and tenderness on the face, chest and back. Erythema nodosum was also present on the arms and legs. Symptoms in the second patient appeared during the course of irradiation therapy for the uterine cancer. High fever, neutrophilia, increased ESR and positive CRP were evident. Histologically, dense infiltrations of neutrophiles with nuclear deposits were present in the dermis. Administration of DDS and potassium iodide led to a dramatic improvement of case 1 and 2, respectively and there was no recurrence. The pathogenesis of Sweet’s syndrome appears to be similar to that of erythema nodosum.
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  • A Probable Case of Hygroma
    Shiro NANIWA, Kazuo HISAMOTO, Yasunori OKAZAKI, Chidori ASAGAMI, Hides ...
    1983 Volume 45 Issue 6 Pages 987-990
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.987
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    A probable case of hygroma occurred in the sacral region of a 31-year-old Japanese woman. The surgically removed lesion was a cyst with a connective tissue appearance and had adhered to the sacrum. Histopathologically, the inner surface of the cyst was lined with two or three layers of cells (probably of synovial nature), surrounded with layers of connective and granulomatous tissues. From the results of clinical, bacteriological, histopathological and ultrastructural examinations, it was suspected that destructive changes around the sacrum, as induced by secondary and opportunistic infections of Staphylococcus epidermidis, Candida and Pseudomonas puterfaciens may have stimulated the occurrence of an incomplete form of synovial membrane from an ectopic and remniscent bursa or undifferentiated mesenchymal cells in the periosteum of the sacrum.
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  • Two Cases of Skin Injury Following Extravasation of Contrast Medium
    Reiko NOGAMI, Shoichiro KUDO, Yoshihiro MAEKAWA
    1983 Volume 45 Issue 6 Pages 991-994
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.991
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    Two cases of skin injury following extravasation of iodinated contrast medium are reported. The tissue reaction by contrast medium, therapy and pathogenesis of skin injury were discussed. In a 3-month-old girl, in whom a diffuse neonatal hemangiomatosis was suspected, contrast enhanced CT-scanning was carried out to look for central nervous system involvement. After about 10ml of Angiographin had been injected into right dorsal vein, an erythematous and swelling lesion appeared over the right lower leg and finally resulted in a skin necrosis around the injected vein. A split thickness skin graft was performed successfully after 3 weeks, without any contracture of the joint. A 77-year-old woman with extramammary Paget′s disease complained of a marked swelling and erythematous lesion over the injected site of her right forearm after contrast medium drip infusion for pelvic CT-scanning. An immediate and local injection of hyaluronidase in physiological saline solution prevented tissue damage including necrosis due to the injected contrast medium. It is well known that accidental extravasation of contrast medium from the vein may occur, yet few cases of skin injury have been reported, particularly by dermatologists. Large amounts of contrast medium will cause various skin reactions and such incidences may well be on the increase.
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Clinical and Investigative Report
  • Assessment of the Clinical Usefulness of Skin Reaction and Leucocyte Adherence Inhibition Test Using SK·SD Antigen
    Yasunori OKAZAKI
    1983 Volume 45 Issue 6 Pages 995-1001
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.995
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    Skin reactions with SK·SD, PPD and PHA and leucocyte adherence inhibition test using SK·SD antigen were performed on 1) healthy controls (28 persons aged between 20 and 59 and 23 persons over 60), 2) 36 patients with disturbances in cellular immunity and 3) 34 patients without this disturbance, in order to assess the usefulness of skin reaction using SK·SD antigen. The skin reaction with SK·SD was useful as one of the markers of cell mediated immunity for patients between 20 and 59 years, while the LAI test using SK·SD antigen seemed to be of little use.
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  • Clinicopathological and Immunological Study of Bullous Pemphigoid
    Toshiro KAGESHITA, Yukihiro OKUMURA, Hiroaki NAGANO, Yutaka MIYAMOTO, ...
    1983 Volume 45 Issue 6 Pages 1002-1009
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.1002
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    Twenty-two cases of bullous pemphigoid diagnosed by immunofluorescent technique were reviewed. Twelve were men and twelve were women. The age at onset of the disease ranged from 38∼84 years. We classified the clinical morphology into 1) bullous type (3 cases), 2) vesicular type (6 cases), 3) erythematous type (2 cases) and 4) mixed type (10 cases). Abnormal laboratory findings were leucocytosis (12), eosinophilia (10), elevated LDH (6), positive CRP (12) and hyper IgE (5). Histologically, neutrophil dominant infiltrates were noted in 2, eosinophil dominance in 10 and lymphocyte dominance in 10. Complications were malignant tumors (2), hypertension (4), diabetes mellitus (3) and thyroid dysfunction (2).
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  • Three Cases of Pityriasis Rubra Pilaris
    —Systemic Treatment with Aromatic Retinoid (Ro-10-9359)
    Kazuo ASO, Yohtaro KATAGATA, Seikichi TOKU, Shuichi WATANABE, Yoshihir ...
    1983 Volume 45 Issue 6 Pages 1010-1017
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.1010
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    Three cases of pityriasis rubra pilaris—a 25 year-old man (adult type), a 7-year-old boy (familial infant type) and a 4-year-old boy (non-familial infant type) were treated with retinoid. The response to this treatment was marked in all patients. The effect was superior to those seen with oral Vitamin A. The abnormal electrophoretic patterns of keratin improved after the treatment.
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  • Measurement of Cutaneous Blood Flow by Hydrogen-Gas Clearance Method
    Norifumi TAKEUCHI, Takashi OGUNI, Fumio SHIGEMI, Katsuyuki TAKEDA
    1983 Volume 45 Issue 6 Pages 1018-1023
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.1018
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    Cutaneous blood flow (CBF) was measured quantitatively on fifteen regions of twelve volunteers using the hydrogen-gas clearance technique. Simultaneously, skin surface temperature (SST) was measured on the same regions. The mean value of CBF on the forehead (106.2±35.1 ml/min/100g) was highest, followed in order by that of flexor aspect of the upper arm, extensor aspect of the upper arm, flexor aspect of the forearm, chest, back, abdomen, back of the hand, back of the foot, posterior aspect of the thigh, extensor aspect of the forearm, anterior aspect of the thigh, posterior aspect of the leg, anterior aspect of the leg. Mean value of CBF was lowest on the lumbar region (57.8±10.7 ml/min/100g). CBF of the flexor aspect tended to be greater than that of the extensor aspect in the areas of the four extremities. There was no relationship between CBF and SST on the forehead, trunk, extremities. The advantages and disadvantages of using this method to measure CBF are given attention.
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  • Immunofluorescent Study of Pustulosis Palmaris et Plantaris
    Toshiro KAGESHITA, Masayoshi JOHNO, Tomomichi ONO
    1983 Volume 45 Issue 6 Pages 1024-1027
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.1024
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    Twelve cases of PPP were studied using a direct immunofluorescent technique. In all pustules, there was a positive deposition of IgG and C3. In the horny layer, half the samples showed a positive linear deposition of IgG and C3. The pathogenesis of PPP involves immunological mechanisms.
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  • Port Wine Stain and Response to Argon Laser Therapy:
    Predictive Role of Clinical and Histological Types
    Tomomitsu NAKANO, Tadashi TEZUKA
    1983 Volume 45 Issue 6 Pages 1028-1033
    Published: December 01, 1983
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.45.1028
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    The argon laser has been established as an effective modality in the treatment of port wine stain (PWS). Recent studies have suggested that argon laser therapy is beneficial in some, but not all, cases of PWS. To the best of our knowledge, there is no appropriate clinical classification of PWS that predicts the therapeutic responses to argon laser therapy. In this study 100 patients with PWS were classified into 3 clinical and histological groups and their responses to the argon laser examined. These patients were classified into 3 clinical groups, A, B, and C, prior to argon laser treatment. The skin eruption of type A was sharply bordered and intensively red with remarkable telangictasia. Histologically the superficial capillaries were filled with RBC’s. Type C showed a relatively defined border and less red exanthema with lack of telangiectasia and a deeper location of the undilated vessels. Type B was an intermediate type between A and C. The patients then received treatments with the Argon Laser Photo Coagulator System 1000 (Coherent). Each patient was treated identically, receiving 1.2 watts at a 1mm area with a pulse duration of 0.2 seconds. In 6 months or later, the patients were evaluated for the effectiveness of the treatment. The results were evaluated as excellent (total or almost complete blanching without scar), good (marked lightening without scar), fair (slight lightening without scar), and poor (scar or unchanged). The number of cases of type A was 28, type B, 38, and type C, 34. The results were excellent or good in type A, fair in type B, and poor in type C. In conclusion, PWS was classified into 3 groups according to the therapeutic responses to the argon laser.
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Review
Therapy
Dermatologists around the World
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