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Volume 73 (2011)
- Issue 6 Pages 555-
- Issue 5 Pages 461-
- Issue 4 Pages 343-
- Issue 3 Pages 215-
- Issue 2 Pages 123-
- Issue 1 Pages 1-
Volume 73, Issue 3
Displaying 1-16 of 16 articles from this issue
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Color Atlas
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Kana MASUNAGA, Eri YOSHIMURA, Toshihiko MASHINO, Yukiko NAITO, Hiromar ...2011 Volume 73 Issue 3 Pages 215-216
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSDownload PDF (1127K)
Clinical Case Reports
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Akiko MATSUO, Hiroaki HAYASHI, Wataru FUJIMOTO, Junko OCHI2011 Volume 73 Issue 3 Pages 217-220
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSA 59-year-old man presented with erythematous vesicular lesions on the left cheek and eyelids with conjunctival hyperemia 2 days after an operation for injury in the left eye. Contact dermatitis due to a disinfectant or eye drops was suspected. Although the erythematous lesion on the left cheek subsided with topical steroid treatment, the blepharoconjunctivitis of the left eye aggravated. Patch tests showed strongly positive reactions to Mydrin®-P (containing 0.5% tropicamide and 0.5% phenylephrine hydrochloride) and Neosynesin®(containing 5% phenylephrine hydrochloride) eye drops. Patch tests with these ingredients showed positive reactions to 0.005% phenylephrine hydrochloride. After the use of Mydrin®-P was stopped, the blepharoconjunctivitis completely resolved with the use of atropine as a mydriatic agent. The patient had received Mydrin®-P eye drops more than 15 times before the development of blepharoconjunctivitis. The repeated use of eye drops containing phenylephrine for examination probably resulted in sensitization to phenylephrine hydrochloride.View full abstractDownload PDF (1196K) -
Asako YOSHIZAKI, Ayumi YOSHIZAKI, Eiji MUROI, Fumihide OGAWA, Shinichi ...2011 Volume 73 Issue 3 Pages 221-224
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSWe report on a 53-year-old male with digital gangrene. Since 2003, he had experienced Raynaud's phenomenon with repeated digital ulcers in winter. His ulcers had in the past resolved themselves without further treatments in spring. However, in November 2007, refractory skin ulcers occurred on his fingertips and developed into gangrene. He received a diagnosis of digital gangrene complicated with systemic sclerosis because of skin sclerosis of his fingers and detection of serum anti-RNA polymerase I/III antibodies. The gangrene successfully healed with combined conservative therapy by prostaglandin E1, antiplatelet aggregation drugs and local treatment.View full abstractDownload PDF (1260K) -
Eri YOSHIMURA, Kana MASUNAGA, Toshihiko MASHINO, Kayo HARADA, Tomoyo K ...2011 Volume 73 Issue 3 Pages 225-228
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSA 2-month-old girl presented with erythematous annular plaques on the left temporal region of the head and the chest that had begun when she was 6 days old. Skin biopsy showed liquefaction of the basal cells. Examination of blood showed the presence of hepatitis, anti SS-A/Ro and anti SS-B/La antibodies, confirming a diagnosis of neonatal lupus erythematosus (NLE). Her electrocardiogram was normal. The skin lesions gradually disappeared by 6 months, with sun protection and topical corticosteroids, parallel to the disappearance of the hepatitis and the decrease of the autoantibody levels. Her mother tested positive for anti SS-A/Ro and anti SS-B/La antibodies, but did not complain of any symptoms of collagen disease. We reviewed 26 cases of NLE in Japan whose mothers did not have collagen disease at delivery. Consequently, among 26 mothers, 9 were only positive for autoantibodies, 16 were diagnosed as having Sjögren's syndrome, and one was diagnosed as having systemic lupus erythematosus.View full abstractDownload PDF (1114K) -
Akiko KAMEGASHIRA, Hideki NODA, Shunsuke TAKAHAGI, Takaaki HIRAGUN, Mi ...2011 Volume 73 Issue 3 Pages 229-232
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSWe report on a 5-month-old boy whose hair, eyebrows, and eyelashes have been almost absent since he was born. He has often suffered from unidentified fever and sinusitis since 14th days after birth, and his hair growth has remained sparse. He also exhibits characteristic facial features, such as prominent lower jaw and forehead, a saddle nose, and thick protrusive lips. Moreover, only one tooth was recognized on a face X-ray. Furthermore, the sweat response was not observed by the thermoregulatory sweat test or the acetylcholine sweat-spot test. Based on these findings, the boy was diagnosed as having anhidrotic ectodermal dysplasia. His family history revealed that his mother also had defective tooth formation. A DNA sequencing analysis demonstrated that he and his mother had an identical missense mutation (c. 1037G>A) in exon 9 of the EDA gene on one X chromosome, indicating that his mother was a heterozygous carrier.View full abstractDownload PDF (1204K) -
Ayako KINOSHITA, Shoichi MATSUBA, Utako KIMURA, Yuki MIZUNO, Yasushi S ...2011 Volume 73 Issue 3 Pages 233-236
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSAn 80-year-old man presented with a case of isolated atypical fibroxanthoma on the face. His chief complaint was a nodular lesion on the left nasal wing that had enlarged gradually over several years. At the first visit, a 1.5 cm diameter reddish nodular lesion with crusting in the center was found on the alinasal area. Squamous cell carcinoma, adnexal tumor, soft tissue neoplasm, or keratoacanthoma were suspected, and the tumor was resected under local anesthesia. Histological examination showed that the tumor consisted mainly of bizarre atypical spindle cells in a fascicular pattern, and partially of giant cells and foamy cells, with epidermal collarettes. The tumor cells were positive for vimentin and α-antitrypsin, and negative for cytokeratin, S-100 protein, and CD34. The final diagnosis was a typical case of atypical fibroxanthoma. The patient was treated by a palliative resection of the tumor because of his poor general condition and severe liver cirrhosis.View full abstractDownload PDF (1219K) -
Miho OGATA-MASUOKA, Noriyuki MISAGO, Haruko UEMURA, Shinichi KOBA, Yut ...2011 Volume 73 Issue 3 Pages 237-240
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSA 29-year-old woman had noticed a black nodule on her right hip that had gradually increased in size during pregnancy. However, the size of the nodule had decreased after a miscarriage. The lesion was surgically resected, and we diagnosed malignant melanoma of pT4aN0M0 stage II B. After five course of DAV-IFN therapy, multiple metastases were recognized, and she died of the disease 2 years after the operation. In our case, it was very interesting that the nodule became smaller after miscarriage, this suggested a correlation of pregnancy with melanoma.View full abstractDownload PDF (1246K) -
Makiko ONO, Shinichi KOBA, Machiko HISATOMI, Asuka KITAYAMA, Noriyuki ...2011 Volume 73 Issue 3 Pages 241-244
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSA 55-year-old female presented with a bluish subcutaneous nodule on her left thigh. Magnetic resonance imaging (MRI) indicated a panniculitis or traumatic change. While undergoing surgical treatment, an ivory-white, ribbon-like worm was detected and identified as plerocercoid larvae; the infection was diagnosed as sparganosis mansoni based on the pathological examination. Other lesions of this disease were not detected by the image test of the whole body. Because the lesion remained after surgical treatment, praziquantel was administered. After that, the lesion disappeared immediately, and the IgG antibody level to plerocercoid antigen of Spirometra erinaceieuropaei descended markedly three months later. The current case indicates that parasite disease, including sparganosis mansoni, should be considered even in non-migratory and unchanging subcutaneous nodules.View full abstractDownload PDF (1185K) -
Keiko NAKAHASHI, Hiroyuki TAKAHASHI, Makiko KAGAYA2011 Volume 73 Issue 3 Pages 245-247
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSA 55-year old female patient with advanced colorectal carcinoma was referred to us, for the treatment of cutaneous toxicity induced by cetuximab. Although typical acneiform eruptions appeared on her face after second treatment with cetuximab, the treatment was stopped after fourth administration because of rapid exacerbation of these eruptions. On admission to our hospital, she showed facial eruptions similar to those observed in dermatitis with impetiginization, Candida albicans was however revealed by microscopic and culture studies. Therefore, her facial complications were diagnosed as atypical cutaneous candidiasis that was induced under immunosuppressive condition secondary to cetuximabtreatment and topical steroid application. Although cutaneous toxicity was promptly improved by the application of a topical anti-fungal cream, colorectal carcinoma was remarkably worsened. Adverse reactions induced by cetuximab treatment are well-known; however, some patients show unexpected reactions secondary to cetuximabtreatment. Therefore, dermatologists play an important role in ensuring that the quality of life (QOL) of patients is improved during the course of cancer treatment, particularly by careful inspection of the alteration of skin manifestations and an early recognition of unexpected cutaneous toxicities.View full abstractDownload PDF (1226K)
Clinical and Investigative Report
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Kazuya OOI, Noriyasu MITANI, Masahiko HAYASHI2011 Volume 73 Issue 3 Pages 248-252
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSWe investigated the combination of dexamethasone valerate ointment (Voalla® ointment) and water-in-oil-based moisturizing ointment (Hirudoid® soft ointment) to determine whether the topical drug application sequence (moisturizing ointment on glucocorticosteroid ointment or glucocorticosteroid ointment on moisturizing ointment) influences percutaneous absorption of dexamethasone valerate in isolated pig ear skin and in living human skin. The dose was administered with glucocorticosteroid ointment alone (group A). Then the dose was initially administered with glucocorticosteroid ointment preceding moisturizing ointment (group B). And finally, the dose was administered with moisturizing ointment preceding glucocorticosteroid ointment (group C). This study evaluated the skin penetration of dexamethasone valerate from glucocorticosteroid ointment, using non-viable excised pig ear skin samples (n =8). We measured the concentration of dexamethasone valerate in isolated pig ear skin by HPLC. We obtained information on the depth profiles of dexamethasone valerate in living human skin (n =2) by confocal Raman spectrometer. The permeability of dexamethasone valerate of pig ear skin was compared among groups A, B and C. Group A demonstrated the highest concentration of dexamethasone valerate penetrating the skin. The permeability of dexamethasone valerate when moisturizing ointment was applied on glucocorticosteroid ointment (group B) was greater than that when glucocorticosteroid ointment was applied on moisturizing ointment (group C) (p <0.01 ; t-test). Our findings were similar in both isolated pig ear skin and in living human skin.View full abstractDownload PDF (1267K)
Review
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— Antigen Analysis —Eishin MORITA2011 Volume 73 Issue 3 Pages 253-259
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
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Therapy
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Toshinori BITO, Shun OHMORI, Mayuko YOSHIZAWA, Sanehito HARUYAMA, Yu S ...2011 Volume 73 Issue 3 Pages 260-265
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSWe evaluated the therapeutic effectiveness of photodynamic therapy (PDT) using a metal halide lamp for actinic keratosis (AK) and Bowen's disease (BD). Thirty-one lesions of AK from 24 patients and 8 lesions of BD from 6 patients were involved in this study. After clinical remission, the efficacy of PDT treatment was histologically examined by punch biopsy. p53 protein expression was also assessed in serial specimens. Twenty-seven of 31 AKs and 5 of 8 BDs were diagnosed as having complete remission (CR). No harmful side effects were observed during the course. AKs were histopathologically divided into 5 groups, in which the required doses for CR were further investigated. From this study, we propose an initial irradiation dose for BD and AK that provides optimal effectiveness. Treatment with PDT using a metal halide lamp can be one of the first-line therapies for AK and BD.View full abstractDownload PDF (1330K) -
Motoi TAKENAKA, Shinichi SATO2011 Volume 73 Issue 3 Pages 266-270
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSBetamethasone butyrate propionate ointment, one of the most commonly used topical corticosteroids for dermatoses, has been demonstrated to be clinically effective. In the present study, we assessed the clinical efficacy of this ointment and its effects on patients' quality of life (QOL). The subjects were 30 patients with eczema or dermatitis. Of these patients, three had also been treated with antihistamines or antiallergic drugs from before the initiation of treatment with this ointment, and 27 received this topical preparation alone. Significant improvement was observed with respect to erythema or edema, papules or vesicles, lichenification, erosion, scales, and scratching, compared to the status before treatment. Assessment of the overall effect revealed moderate or greater improvement in 87% of the patients. Evaluation on a visual analog scale (VAS) showed significant improvement of both skin symptoms and itching. QOL evaluated using the Dermatology Life Quality Index (DLQI) was significantly improved to 0.93 ± 0.27 from 4.17 ± 0.49. Notably, significant improvement was seen in the domains “symptoms and feelings”, “daily activities”, and “work and school”. These findings indicate that improvement of skin symptoms by this topical drug contributed to improvement of QOL. The itching experienced by the study patients was alleviated by this topical preparation alone. These findings suggest that betamethasone butyrate propionate ointment is useful in many ways, and that it could be the drug of first choice for topical therapy of dermatoses.View full abstractDownload PDF (1437K) -
Atsushi FUKUNAGA, Chikako NISHIGORI, Kei ITO, Hiroshi SHIMIZU, Rikako ...2011 Volume 73 Issue 3 Pages 271-277
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSWe tested 3 sunscreen products on 49 test subjects from May to December 2009. The subjects were patients suffering from photosensitivity and patients whose dermal conditions had worsened to erythematosus due to sunlight exposure ; these patients had presented at 5 medical institutions. For our study, each of the patients was asked to use one or more of 3 sunscreen products, according to the severity of the required shielding, on an area of the body exposed to sunlight for a period of 4 weeks. The sunscreens were NOV®UV lotion EX, NOV®UV shield EX, and NOV®UV stick EX, products that do not contain ultraviolet light absorbing agents but contain micronized titanium dioxide as an ultraviolet light scattering agent. Two of the test subjects stopped using the sunscreen due to the development of erythema and pruritis at the site of application ; however, their cutaneous symptoms spontaneously improved a few days after the discontinuation. For the other 47 patients, who continued using the sunscreens, we obtained cutaneous assessments from their attending physician before and after the test. We then measured the level of oxidized protein and TNF-α, which were produced from the horny layer of the epidermis on exposure to ultraviolet light, by using the tape-stripping method, and verified a statistically significant difference between the results before and after the test. Furthermore, we carried out the same usage tests on 77 patients with conditions such as atopic dermatitis, for whom the avoidance of ultraviolet light is desirable for therapeutic reasons, and confirmed that the sunscreens are safe for these patients as well. Based on these results, we concluded that the 3 products examined in this study can be used safely by photosensitive patients and patients whose dermal condition worsens due to sunlight exposure, and that these products are highly effective sunscreens.View full abstractDownload PDF (1314K) -
Makoto KAWASHIMA, Hidemi NAKAGAWA2011 Volume 73 Issue 3 Pages 278-289
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSA double-blind, parallel group comparative study was conducted to investigate efficacy and safety of olopatadine hydrochloride (HCl) in atopic dermatitis in children using ketotifen fumarate dry syrup as a comparator. Patients with atopic dermatitis aged 7 to 16 years and weighing more than 20 kg were enrolled in the study. A total of 305 patients were randomized to oral treatment with olopatadine HCl at 5 mg (Group O) or with ketotifen fumarate dry syrup at 1 g (Group K) twice daily for two weeks. The primary endpoint was analyzed on the FAS population consisting of all 305 patients. Changes in the itching score from the pre-dose baseline values to the last measurements, the efficacy primary endpoint of the study, were determined by analysis of covariance using the baseline values as covariates. The analysis demonstrated noninferiority in Group O compared with Group K. So far as safety is concerned, the incidences of adverse events were 19.1% (29/152 patients) and 24.2% (37/153 patients) and those of adverse drug reactions were 11.8% (18/152 patients) and 6.5% (10/153 patients) in Group O and Group K, respectively. No serious or“severe”grade adverse events were reported in either group, and there seem to be no clinical safety concerns associated with the treatment. Based on the above findings, we conclude that olopatadine HCl is as effective as ketotifen fumarate in treating atopic dermatitis in children.View full abstractDownload PDF (1497K)
Dermatologists around the World
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Kazuo NOMURA2011 Volume 73 Issue 3 Pages 301-302
Published: June 01, 2011
Released on J-STAGE: September 28, 2011
JOURNAL RESTRICTED ACCESSDownload PDF (1157K)
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