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Volume 64 (2002)
- Issue 6 Pages 673-
- Issue 5 Pages 531-
- Issue 4 Pages 405-
- Issue 3 Pages 275-
- Issue 2 Pages 147-
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Volume 64, Issue 5
Displaying 1-23 of 23 articles from this issue
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Color Atlas
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Shohei FUJITA, Yuichi YOSHIDA, Kazunori URABE, Masutaka FURUE2002 Volume 64 Issue 5 Pages 531-532
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSDownload PDF (333K)
Clinical Case Reports
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Toru MORI, Yoshihiro MIURA, Junji NAKAFUSA, Noriyuki MISAGO, Yutaka NA ...2002 Volume 64 Issue 5 Pages 533-536
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSWe report two rare cases of temporal arteritis involving the occipital artery. The first case was a 76-year-old woman who was found to have tender, tortuous swollen temporal and occipital arteries and a mild fever. The second case was an 80-year-old woman who was admitted our hospital because of a headache in the bilateral temporal and occipital regions and a mild fever. Laboratory tests of the two cases revealed an extremely elevated ESR and a high CRP level. A histological examination of the superficial temporal arteries in these two cases showed arteritis with giant cell infiltration. The symptoms improved after the oral administration of prednisolone at a dose of 40mg/day in both cases.View full abstractDownload PDF (1773K) -
Yoshiko MATSUMOTO, Shinji MURAKAMI, Koji HASHIMOTO2002 Volume 64 Issue 5 Pages 537-540
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA 66-year-old man suffering from chronic hepatitis C developed a finger tip ulcer. Laboratory evaluations revealed a positive rheumatoid factor, cryoglobulin, and positive hepatitis C antibodies. He was diagnosed to have type III cryoglobulinemia because the serum cryoglobulin was composed of polyclonal IgG, IgA and IgM. The use of a stellate ganglion block and the intravenous injection of Alprostadil effectively improved the symptoms. Cryoglobulinemia involves a variety of symptoms, but it was noteworthy that his skin lesions developed only on his finger tips but were not observed on the legs. We speculate that the cause of his skin lesions localized on the finger tips may be the result of Raynaud’s disease due to the long-term use of a lock drill or cryoglobulinemia.View full abstractDownload PDF (874K) -
Manabu MAEDA, Takaharu YAMAZAKI, Mari ARAKI, Hiroaki IWATA, Mai ENDO, ...2002 Volume 64 Issue 5 Pages 541-547
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSTwo cases of dermatomyositis with reversible psychological symptoms are reported. A 65-year-old male, who had been admitted to a local hospital, visited our department complaining of fatigue and erythema. Three days after corticosteroid therapy (predonisolone; PSL 100mg/day), he experienced temporal auditory aphasia but recovered 2 days later. Several days later, however, he experienced similar aphasia for 2 days while being treated with PSL (180mg/day). He died on Jan. 12, 1998 because of fuluminant pulmonary fibrosis. The other case was a 40-year-old female who noted exudative erythema on her hands and feet with arthralgia. After admission, during PSL pulse therapy, she complained of sleep disturbance, and there after a temporal disorientation was seen after oral medication of PSL; 50mg/day. Later, the same symptoms occurred again during oral medication of PSL; 25mg/day. There were no abnormal features on a CT scan of the brain in either case, even though both cases appeared to reveal symptomatic psychological disturbances, which might also be induced by the administration of high dosages of corticosteroids.View full abstractDownload PDF (1952K) -
Eiichi NISHIO, Akimichi MORITA, Noriyuki SAKAKIBARA, Masaki HASEGAWA, ...2002 Volume 64 Issue 5 Pages 548-551
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSWe report the case of 68-year-old woman who had been suffering from a chronic leg ulcer for 23 years. In 1999, she was diagnosed to have Sjögren’s syndrome. She also developed psoriasis vulgaris as well. In March of 2000, the size of the ulcer increased. The laboratory data revealed positive antiphospholipid antibodies. Cutaneous biopsy specimens of the ulcer demonstrated segmental hyalinizing vasculitis. The underlying mechanisms of the ulcer were found to be related to antiphospholipid syndrome, segmental hyalinizing vasculitis, and hypergammaglobulinemia.View full abstractDownload PDF (841K) -
Hideki MAEJIMA, Yumi SHIMAMURA, Kazumi SAITO, Harumi HARADA, Hikaru ET ...2002 Volume 64 Issue 5 Pages 552-556
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSWe herein describe two cases of granulomatosis idiopathica. Case 1. The patient was a 42-year-old man. He has noticed swelling on his forehead and eyelids with no redness, no pain, nor local heat since 1997. He had no other previous illness, such as infectious disease, allergic disease, dental caries or injury. He was referred to our department. Histopathologically, there were numerous lymphocytes, plasma cells and epithelioid cells which infiltrated areas around dilated blood vessels in the deep dermis. Case 2. The patient was a 25-year-old woman. She developed edematous lesions similar to case 1 on the left upper eyelid and she also had no previous illness. Histopathologically, there were dilated blood vessels and numerous lymphocytes which infiltrated the perivascular regions, but no epithelioid cells were seen. Toluidine blue staining showed numerous mast cells with or without degranulation which exsisted perivasculary in cases 1 and 2. Toluidine blue staining seems to be useful in the diagnosis of granulomatosis idiopathica, especially in early stage cases which histopathologically lack granulomatous reaction (such as in case 2). We analyzed 9 cases of granulomatosis idiopathica, simlar to cases 1 and 2 and 73 cases of cheilitis granulomatosa reported over the past 20 years in Japan. The major causes of cheilitis granulomatosa were metal allergy and infectious disease (dental caries), however, most cases of granulomatosis idiopathica did not show any special causes such as in cases 1 and 2.View full abstractDownload PDF (1261K) -
Hirotaka ASAGA, Yoshio HASHIMOTO, Hajime IIZUKA, Noriaki TOYOTA, Marik ...2002 Volume 64 Issue 5 Pages 557-562
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA 66-year-old woman presented with large atrophic and scarring lesions with ulcerations on her right leg. Cutaneous biopsy specimens and laboratory data established the diagnosis of sarcoidosis. The cutaneous lesions with ulcers responded well to systemic prednisolone therapy. Although a large variety of morphologic patterns has been described in the literature, ulcerative skin lesions are unusual in sarcoidosis. We adovocate that ulcerative skin sarcoidosis is among the rare but distinctive forms of skin sarcoidosis, which show fairly characteristic clinical manifestations and also tend to demonstrate a normal course.View full abstractDownload PDF (2921K) -
Yoshiko KAGIMOTO, Hiromichi TAKESHITA, Tetsuya KOGA, Masutaka FURUE, S ...2002 Volume 64 Issue 5 Pages 563-566
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA 66-year-old man, who had been injured in a coalmine explosion 40years earlier, was found to have multiple subcutaneous nodules and indurated plaques at the sites of disseminated posttraumatic scars on his right arm and leg. A biopsy specimen obtained from the multiple subcutaneous nodules on his right dorsal hand showed noncaseating epithelioid cell granulomas, including foreign bodies which were mainly composed of SiO2. Furthermore, an elevated level of angiotensin-converting enzyme and the presence of bilateral hilar lymphadenopathy and uveitis were also found. We diagnosed this patient to have intra- and subcutaneous multiple scar sarcoidosis.View full abstractDownload PDF (1684K) -
Mikako MORIYA, Yoshihiro UMEBAYASHI, Hitoshi TOJIMA2002 Volume 64 Issue 5 Pages 567-569
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA 31-year-old man visited our hospital because of generalized skin eruptions on February 16th, 1998. One week before the onset of the eruption, he developed symptoms of an upper respiratory tract infection. He developed numerous guttate erythemas with scaling on the trunk and extremities. A histopathological examination showed the lesion to be consistent with acute guttate psoriasis. Laboratory studies revealed increased ASO and ASK levels. HLA typing was HLA-A33(19), A11, B17, B70, Cw3, Cw7. He was successfully treated with oral antibiotics. However, the skin eruptions recurred in July 1998 and March 1999. In the latter case, he also demonstrated prodrome. In each case, the eruptions completely subsided within 2 months. A repeated throat culture yielded Streptococcus pyogenes. After a tonsillectomy performed in May, 1999, no recurrence of the disease has been observed for 2 years. A throat culture did not yielded any bacteria. A recurrent case of acute guttate psoriasis is rare, at least in Japan. A tonsillectomy may be an effective therapeutic modality for these cases.View full abstractDownload PDF (687K) -
Misato AMAYA, Yoshihide HONDA, Masaomi YAMASHIRO2002 Volume 64 Issue 5 Pages 570-573
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA female infant who was born after a full-term spontaneous normal delivery, developed at birth several vesicles and erosions on her left leg, both arms and on the left side of her abdomen. Some of them were linearly arranged. The peripheral eosinophil fraction was 12%. Histologically, intraepidermal vesicles and spongiosis with marked infiltration of eosinophils were observed. From these findings, incontinentia pigmenti was diagnosed. There was no family history of this disorder. She also had a nasolacrimal obstruction, but this spontaneously resolved within three months after birth. We defined mild type incontinentia pigmenti as cases with unilateral eruptions on any of the face, trunk, arms and legs. We summarized the patients with incontinentia pigmenti reported in Japan, classifying then into mild-type and common-type, and carefully evaluated the clinical characteristics of both types while also referring to the literature.View full abstractDownload PDF (856K) -
Yuri UCHINO, Hidehiko SHIMADA, Tomoko FUKUSHIGE, Yoshihiko KATAHIRA, T ...2002 Volume 64 Issue 5 Pages 574-577
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA 79-year-old man with blastic NK cell lymphoma is reported. He presented with erythematous-brown papules and plaques on his skin. A biopsy of the cutaneous lesions showed dense atypical lymphoid cell infiltration in the superficial and deep dermis. The cells showed a lymphoblastoid morphology. These cells were positive for CD4 and CD56. Epstein-Barr viral RNA was negative according to the findings of in situ hybridization. The final diagnosis was blastic NK cell lymphoma, and the patient died of this disease two months after the initial presentation.View full abstractDownload PDF (918K) -
Mitsuhiro SEKIYAMA, Kenjirou TERASAKI, Takurou KANEKURA, Tamotsu KANZA ...2002 Volume 64 Issue 5 Pages 578-580
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA 49-year-old man complained of a pedunculated nodule on his right inguinal region which he had first noticed when he was 9 years old. A physical examination showed an 8 × 5cm pedunculated tumor. There was no swelling in the regional lymph nodes. Based on histopathological and immunohistochemical examinations, a diagnosis of DFSP was made. However, the tumor contained focal areas that were microscopically indistinguishable from fibrosarcoma.View full abstractDownload PDF (1432K) -
Kenji SAITO, Akihiko KOMURA, Masato UEDA2002 Volume 64 Issue 5 Pages 581-585
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSWe report a 34-year-old female patient presenting with malignant melanoma which was presumed to occur on a dysplastic nevus. Since adolescence she had multiple moles, two of them on the trunk and one on the lower leg which had recently increased in size. Two moles on the trunk were diagnosed to be dysplastic nevi clinicopathologically. The lesion on the lower leg showed malignant melanoma cells in the epidermis and the superficial dermis in continuity with nevus cells in the mid-dermis, giving a diagnosis of superficial spreading melanoma developing from dysplastic nevus. We furthermore surveyed 23 cases of melanoma associated with dysplastic nevus in Japanese and analyzed their clinicopathological features. The average age of the patient was 35 years old. These included 12 cases of superficial spreading melanoma and 8 cases of nodular melanoma, but no acral lentiginous melanoma was reported. Fifteen cases developed on trunk, 7 cases on the extremities and a case on face. A further compilation of Japanese cases is necessary to reveal the biological significance of dyplastic nevus in Japanese.View full abstractDownload PDF (1910K) -
Wen-ya CHEN, Tetsuo SHUKUWA, Kenichiro IMAZATO2002 Volume 64 Issue 5 Pages 586-590
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSWe report two patients with subungual melanoma (SUM) that developed after traumatic onycholysis. Case 1: A 61-year-old man had SUM Stage II (pT3N0M0) on his left index finger, which he had struck twice with a hammer 10 years ago. Half of his nail was removed at that time and the wound had been repeatedly infected since then. A granulomatous nodule was present on his left index finger. Histology of the nodule showed malignant melanoma with a tumor thickness of 2.0mm. Case 2: A 58-year-old woman had SUM Stage III B (pT4N1M0) on her right thumb. She had injured the nail of her right thumb with a thick staple in a corrugated cardboard box soon after burning the thumb one year ago. The nail was completely removed, and a gray-colored nodule later developed on it. Histological examination showed malignant melanoma with a tumor thickness of 5.0mm. She had already experienced axillar lymph node metastasis. Previous reports of 14 cases and our cases indicate that severe trauma with destruction or deformity of a nail tends to cause invasive melanoma, greater than pT2. It should be noted that six of sixteen cases had melanomas after repeated trauma on the nail.View full abstractDownload PDF (1297K) -
Hidezumi KIKUCHI, Motoki KUROKAWA, Nobuaki CYOUSA, Yukichika ISHII, Ay ...2002 Volume 64 Issue 5 Pages 591-594
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSWe herein report five female cases of measles (a 2-month-old infant, her 29-year-old mother and 3 adults) who visited our hospital within one month. Koplik’s spots were present in four cases, including the infant. All adult patients showed severe general symptoms of high fever (more than 38°C), general fatigue, cough, diarrhea, and so on. Four cases, including the infant, had elevated aminotransferase. All the adult patients had hypoxemia without breathing difficulty, although their chest roentgenograms revealed minimal abnormal shadows. The rate of vaccination against measles, is still about 70-80% and an outbreak of measles patients occurs every several years. Moreover, the number of adult and infant patients is also increasing. Japan where more than 100,000 cases of measles are seen every year, remains a developing country with respect to measles prevention.View full abstractDownload PDF (966K) -
Shigeruko IIJIMA, Toru OGAWA, Naoto YAMAGUCHI, Itaru EBIHARA2002 Volume 64 Issue 5 Pages 595-599
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSA 66-year-old man with chronic renal failure who had undergone hemodialysis for four years visited our dermatology clinic for the treatment of diabetic gangrene on his left foot. The gangrene was followed by a tylosis infection in his foot and which resulted in the exposure of the 5th metatarsal bone which was treated using intravenous antibiotics and prostaglandin E1, and several topical ointments with poor improvement. γ-Linolenic acid, one of polyunsaturated essential fatty acids, 300mg/day, was then orally administered to the patient. Fairly good granulation tissue appeared soon, and the ulcer healed completely after a 16-week administration of γ-linolenic acid. However, chronic suppurative osteomyelitis of the 5th metatarsal bone was soon detected by an X-ray examination. It was successfully treated by a combination of intravenous antibiotics and oral γ-linolenic acid. The patient continued to take γ-linolenic acid which prevented a recurrence of the disease. Thermography before and after taking γ-linolenic acid for 1 year revealed a marked improvement in the skin temperature. We demonstrated the efficacy of γ-linolenic acid for the treatment of diabetic foot in hemodialysis patients and also discuss the mechanism of its action.View full abstractDownload PDF (1145K)
Review
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Diagnosis and Therapy (the first part)Mitsuru SETOYAMA2002 Volume 64 Issue 5 Pages 600-605
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
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Therapy
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Maki HATA, Yoshiki TOKURA, Masahiro TAKIGAWA, Yoshinori TAMURA, Genji ...2002 Volume 64 Issue 5 Pages 606-611
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSSince in atopic dermatitis, an insufficiency of ceramides in the stratum corneum is an etiologic factor in dry and barrier-disrupted skin, we used 8% pseudoceramide-containing cream in the forearm skin of atopic dermatitis patients (n=20, average 26.4 years old) to compare their effect on the clinical appearances, water-holding function, and transepidermal water loss (TEWL) with 10% urea cream. We found that ceramide cream effectively improved the atopic dry skin in 60% of all patients tested. The measurement by TEWL showed no significant difference between before and after the application with ceramide cream, whereas the water content in the stratum corneum (conductance value) significantly increased in comparison to before application. Although there was no significant difference in lesional elements (dryness, scale, itching and follicular papules), TEWL value, or water content between ceramide and urea creams during the treatment period, the ceramide cream was found to be significantly superior to urea cream. These results indicate ceramide cream to have a high clinical efficacy for the treatment of atopic dry skin as a modulator for the stratum corneum functions.View full abstractDownload PDF (1313K) -
Iwao TAKASHIMA, Keiko HASEBE, Minehiro OKUDA, Genji IMOKAWA2002 Volume 64 Issue 5 Pages 612-620
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSAtopic dermatitis (AD) is a chronically relapsing dermatitis that is characterized physiologically by a disrupted barrier function and water-holding property in the stratum corneum, predisposing skin inflammation and itch sensation due to enhanced cutaneous permeability and dry skin, respectively. This dysfunction of the stratum corneum results from a decreased amount of ceramide, a major constitutive of the intercellular lipids within the stratum corneum layers. Since topical compensation of ceramide has been reported to result in recovery of the disrupted function of the stratum corneum in patients with AD, it would be interesting to determine whether stratum corneum dysfunction induced by washing with surfactants that are known to eliminate ceramide from the stratum corneum could be restored by the exogenous addition of ceramide to the detergent formulation. In this study, we examined the clinical and physiological effects of pseudoceramide-containing detergent formulation applied to the skin of patients with AD and asteatotic eczema. Clinical observations of skin appearance for 4 weeks revealed that application of 1% pseudoceramide-containing detergent formulation had improved the atopic skin symptoms, including dry skin, in 95.3% of the patients. In accordance with the clinical improvement, there was a significant increase in the water-holding property of the stratum corneum in the patients with AD and asteatotic eczema after 2 and 4 weeks of treatment. These results indicate that application of a pseudoceramide-containing detergent formulation to atopic dry skin in very effective for improving systems as a result of the preventive and restorative effects of pseudoceramide.View full abstractDownload PDF (2268K) -
Noriko MURAYAMA, Masataro HIRUMA, Koichi HIRAMOTO2002 Volume 64 Issue 5 Pages 621-624
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
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Ryoji TSUBOI, Rie UEKI, Kayako HIRA, Fumiko IKEJIMA, Emiko YAMAMOTO, H ...2002 Volume 64 Issue 5 Pages 625-630
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSThe efficacy and safety of application of camellia oil in conjugation with a treatment using camellia oil-containing shampoo for various scalp diseases were evaluated. Fifty-two subjects with mild scalp diseases, such as atopic dermatitis and seborrheic dermatitis, were enrolled in this study. Camellia oil was applied to the whole scalp and rinsed off roughly 5 to 10 minutes later with warm water. The scalp and scalp hairs were then washed using a shampoo containing camellia oil. These procedures were performed once daily for four weeks without any modification in the routine treatment of the patient’s disease. Grades of clinical manifestations, such as redness, wetness, scaling, encrustation, dryness and itching, were recorded weekly. Efficacy of the treatment was evaluated in 37 cases, and the results indicated that scores in scaling and encrustation significantly improved. The percentage of subjects who showed slight to significant improvement was 78.4%. The skin manifestations were exacerbated in two cases, and adverse effects were observed in five cases. The patients were later asked to answer a questionnaire regarding their impressions of the treatment, 69.7% of the patients answered that they found the treatment refreshing and not too oily (as in leaving an oily residue). These results suggest that a combination of camellia oil and shampoo containing camellia oil is a good hair and scalp-washing product for patients with various scalp diseases.View full abstractDownload PDF (1536K) -
Juichiro NAKAYAMA, Yumiko KUBOTA, Akira TAKAHASHI, Akihiko SHIMIZU2002 Volume 64 Issue 5 Pages 631-638
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSThe effectiveness and safety of twice-daily treatment with calcipotriol ointment were evaluated in 18 patients with moderate to severe psoriasis. Results for inpatients treated with calcipotriol ointment for 2 weeks under strict control were compared with those for outpatients who treated themselves with calcipotriol for 2 weeks at home. The clinical effects of both treatments were almost the same, suggesting that outpatients adhered to the physician’s prescription. After 12 weeks, the mean percentage of clinical improvement based on modified psoriasis area and severity index was 80% in outpatients, and the itchiness was improved significantly. Two patients had skin irritation during the period of therapy. No clinically important increase in serum calcium was observed in any of the patients. The impact of calcipotriol ointment on the quality of life of each patient was also evaluated. The score of self-consciousness improved significantly. The degree of satisfaction with the treatment improved from 33% to 80%. Calcipotriol ointment is safe and effective for treatment of psoriasis.View full abstractDownload PDF (1908K)
Dermatologists around the World
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Takeshi HORIO2002 Volume 64 Issue 5 Pages 639-640
Published: October 01, 2002
Released on J-STAGE: September 02, 2010
JOURNAL RESTRICTED ACCESSDownload PDF (1091K)
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