The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 44, Issue 3
Displaying 1-22 of 22 articles from this issue
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Color Atlas
Clinical Case Reports
Clinical and Investigative Report
  • Serum Lipoperoxide in Skin Diseases
    —with Special Reference to the Relationship to Lipoprotein and Lipid—
    Yohko HARA
    1982 Volume 44 Issue 3 Pages 390-399
    Published: June 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.390
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    In studies on serum lipoperoxide and on the relationship to lipoprotein and lipid in serum, the following results were obtained; (1) TBA (thiobarbituric acid) values indicating increases of serum lipoperoxide were noted in patients with psoriasis vulgaris, xanthoma, acne vulgaris and oil poisoning “Yusho”, in significantly larger numbers than in the control group and also in patients with vascular disorders such as allergic vasculitis, Mondor’s disease and systemic lupus erythematosus; (2) Serum lipoprotein electrophoresis revealed that a considerable number of patients with psoriasis vulgaris and “Yusho” showed a type III pattern; (3) Significant correlations were not evidents between TBA and serum lipid values in simultaneously examined patients.
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  • Lipid Peroxide Levels in Sera of Patients with Skin Diseases
    Makoto TAKAHASHI, Kuniji OTSUKI
    1982 Volume 44 Issue 3 Pages 400-404
    Published: June 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.400
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    The lipid peroxide levels in the serum of 175 individuals were measured by the TBA (thiobarbituric acid) method of Yagi5). The mean TBA value of 38 healthy individuals was 2.14±0.41 nmol/ml and differences between male and female were nil.. The TBA values in serum tended to increase with age and decrease in those over 50, albbeit with no statistical significance. High TBA values in the serum were seen in patients with reticulosis, collagen diseases, malignant tumor, psoriasis and malignant melanoma. On the other hand, patients with of herpes zoster, benign tumor and atopic dermatitis revealed the values within the normal range.
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  • Arylsulfatase Activity in Blister Fluids of Bullous Pemphigoid
    Mitsunari HIGUCHI, Tatsumi NISHIO, Mikio ICHIKI, Shingo TSUDA, Yoichir ...
    1982 Volume 44 Issue 3 Pages 405-408
    Published: June 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.405
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    The granules of the eosinophil contain a variety of hydrolytic enzymes, including arylsulfatase A and B. Arylsulfatase activity is known to correlate well with eosinophil levels, and eosinophil arylsulfatase B was found to inactivate ECF-A and SRS-A. Bullous pemphigoid is a chronic cutaneous disease characterized by subepidermal bullae and perivascular accumulation of eosinophils, although the pathomechanisms of the development remain obscure. In the present study, arylsulfatase activity in the blister fluid was investigated to elucidate the role of eosinophils in cases of bullous pemphigoid. Nine patients with bullous pemphigoid were diagnosed using immunological approaches. Bullous fluid was aseptically aspirated and stored at -70°C until use. Blisters in four patients with burns served as the controls. The activity of arylsulfatase was estimated by the amount of 4-nitrocatechol liberated in μg/ml/hr of blister. The increased activity of arylsulfatase was observed in the blister fluid of bullous pemphigoid (A: 6.552±1.083μg/ml/hr, B: 25.797±7.052μg/ml/hr), as compared with findings in the controles (A: 3.118±0.224μg/ml/hr, B: 3.447±0.508μg/ml/hr). The activity of arylsulfatase was remarkably reduced after treatment with prednisolone in two cases. These reductions also correlated well with the levels of peripheral blood eosinophilia and the concentration of IgE in the sera. Demonstration of arylsulfatase in the tissue fluid suggests that hydrolytic enzyme may play a pathogenic role during the initial stage of blister formation in cases of bullous pemphigoid.
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  • Perifollicular Nerve Endings in Guinea Pig
    Electron Microscopic Observation of the Longitudinal Sections
    Motoyuki MIHARA
    1982 Volume 44 Issue 3 Pages 409-415
    Published: June 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.409
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    The perifollicular nerve endings in telogen follicle of the dorsum of a guinea pig, in the longitudinal sections, were examined by electron microscopy. There were two perifollicular nerve endings about 20μm in length on both sides of the outer root sheath. The cytomembranes were separated from those of the basal cells of the outer root sheath by a basal lamina alone. These membranes consisted of axons and cytoplasmic processes of the Schwann cell and were arranged alternately. Axons were classified into two types; one contained many mitochondria, which put both their long axes and their crests in parallel to the basal lamina between perifollicular nerve endings and the outer root sheath; the other had a few cored vesicles 50nm in size and several clear vesicles 30nm in size. These vesicles were considered to be neurosecretory granules. The cytoplasmic processes of the Schwann cells had numerous pinocytotic vesicles and were seen to more numerouson on the sides of axons, as compared to the outer root sheath or dermis.
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  • Cause and Treatment of Ingrown Toenail
    Yoshikado SAKAZAKI, Koichiro MUTO, Toshitatsu NOGITA, Takashi NAGATA
    1982 Volume 44 Issue 3 Pages 416-420
    Published: June 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.416
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    Fifty-one cases of ingrown toenail treated during an 11 year period were studied clinically. Clinical symptoms, causes and treatments were discussed. The female to male ratio was 37 to 14 (2.6 to 1) and 54.9% of the occurrences were in those 10 to 29 years of age. The main cause of ingrown nail was lateral compression of the toe by ill-fitting shoes. Other contributory causes were occupation, sports activities and malformation of nail and toe. As for treatment, it is essential that shoes be sufficiently wide to eliminate lateral pressure. Cutting the nail straight across, inserting a pledget of cotton wool under nail plate or administration of antibiotics is helpful in some cases. If the conservative measures fail, partial nail excision including nail plate and nail matrix is indicated.
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