The Nishinihon Journal of Dermatology

A case of 59-year-old woman who had Recklinghausen’s disease and breast cancer was reported. There are few such cases in the literature. Histologically, metastasis of breast cancer to neurofibroma was evident. Recklinghausen’s disease and breast cancer, cutaneous metastasis of breast cancer and metastasis of neoplasmas to other neoplasmas are discussed.

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Two cases of hyperkeratosis lenticularis perstans are reported. Case 1 was a 59-year-old man with rough, warty papules on the hand, legs and feet. Case 2 was a 43-year-old woman with small hyperkeratotic papules on the hands and feet. In our survey, 28 cases reported in Japan were collected from the literature and the data were analyzed statistically.

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For the previous 3 and a half years, we have experienced 5 patients with subcutaneous dermoid cyst, three of these cysts being located in the upper lid. One of these 3 was a 2-year-old boy, and the other two were 27-year-old and a 24-year-old woman. Prior to surgery, an assessment of the depth of the cyst should be determined, and here xeroradiography is most useful. In addition, computer tomography and consultation with ophthalmologists is beneficial. Histologically, an epidermoid cyst with skin appendages was characteristic; granuloma with hairs was observed in all patients.

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A 36-year-old woman was admitted in March 1980 with left hip-joint pain and asymptomatic skin eruptions. There were 2 types of skin eruptions, i.e., pinhole sized scar with pale-blue discoloration at the I. V. injection sites of the right antecubital fossa and 1-2cm sized reddish-violet macules on the breasts. These skin eruptions developed a few years after having received a large amount of plasma expander (PVP) 14 years ago. Biopsies of the skin, striated muscle and bone marrow showed distinctive gray-blue granules and vacuoles in the cytoplasm of histiocytes stained with hematoxylin-eosin. Elastica van Gieson, orcein, Hale-periodic acid-Schiff (Hale-PAS) and alkaline Congo red stain produced dark brown, pale-brown, blue and dark orange colours, respectively. Histochemically, strong acid phosphatase activity was detected in the granules but such was poor in the vacuoles. Ultrastructural examinations revealed electron dense lysosomal bodies and vacuoles in the histiocytes. When PVP-storage disease is suspected, skin biopsy is highly recommended and various special stainings will usually lead to an accurate diagnosis.

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