Pentobarbital and reserpine were examined for effect upon the action of adrenaline on the carbohydrate values of male Single-Combed White Leghorn chickens. (1) Blood glucose and blood lactate increased and liver glycogen decreased after the administration of 0.3mg/kg of adrenaline. Muscle glycogen decreased after the injection of a smaller dose, 0.03 mg/kg, of adrenaline. (2) Both hyperglycemia and glycogenolysis which had been induced in the liver by adrenaline injection were inhibited by the pretreatment with pentobarbital (30mg/kg) or reserpine (0.1mg/kg). (3) In birds which had been treated with pentobarbital, no changes occurred in the blood lactate and muscle glycogen by adrenaline injection. (4) Blood glucose, blood lactate, and liver and muscle glycogen were not changed in amount by the administration of pentobarbital. (5) The administration of adrenaline caused no changes in blood glucose and liver and muscle glycogen but a marked increase in blood lactate.
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