[in Japanese]

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[in Japanese]

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The arterial system of the bovine uterus has been studied by Ellenbogen, Hanseland Asdell, Hilliger, Reuber and Emmerson, and Tsutsumi. Nevertheless, there havebeen only a few accounts on comparative studies regarding the caruncular region ofnulliparous heifer, multiparous cow, and pregnant cow. In the present investigation, atotal of 61 uteri from l 1 nulliparous heifers, 12 multiparous cows, and 38 pregnant cowswere used. Casts of arteries were prepared for this purpose by means of the intra-vascular injection of acrylic resin. Apart from the casts just mentioned above, tissueblocks were obtained from some uteri injected with resin. Transparent slices andcelloidin sections were also made. In addition to resin-injected materials, those injectedwith gelatine were also used. Paraffin sections of the caruncle were prepared fromnon-injected materials fixed in 10% formalin, Carnoys, Zenkers, or Bouins fluid, andstained with hematoxylin and eosin.The arcuate artery proceeded toward the antimesometrial margin within the stratumvasculare of the uterine wall. Many of them anastomosed with adjacent ones in arxarchfasluion at about 1/2 to 2/3 of the circumference of the horn from the mesometrialmargin. Finally, they terminated in an anastomosis with those of the contralateral rowon the antimesometrial margin. Meanwhile, many smaller arcuate arteries joined thearchfashioned anastomoses described just above. The arcuate arteries in a nulliparousheifer were nearly straight until they formed an anastomosing net, and thereafter theybecame strongly tortuous. On the other hand, those in multiparous cows were stronglytortuous throughout their course. Meanwhile, those arteries were almost straight ina cow which was in the second half of pregnancy.The arcuate artery gave ofl a radial artery to the caruncle and a branch to thecircular muscle. The radial artery usually give origin to a basal artery within thestratum vasculare, which supplied inner one-third of the circular muscle and stratum basale of the endometrium. The main trunk of the radial artery usually bifurcatedonce or twice in the endometrium and finally divided into many arterioles at the baseof the caruncle. These arterioles gave off many pre-capillary vessels which, in turn, continued to the subepithelial capillary net. TIIC radial arteries, especially those inthe caruncular region, were much more tortuous in the multiparous cow than in thenulliparous lueifer. Well-developed capillary networks were also present in the circularmuscle.In tlne second half of pregnancy, the arteries became adapted to the expansion ofthe uterus witlt the following modifications. The radial artery proceeded toward thetop of the peduncle, taking a course almost perpendicular to the base of it. Then, it divided into many arterioles, which proceeded to the bottom of the placentome, takinga fan-fashioned course. At the base of the placentome, these arterioles gave origin tocaruncular radial arteries, which were found to be rather thin at tlaeir origin and whichbecame thicker on their way to the surface of the placentome. The caruncular radialarteries in t[te placentome seemed to be an extension of the pre-capillary vessels whichwere invariably found near the surface of a caruncle in the nulliparous heifer, as wellas in the mu[tiparous cow.

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[in Japanese]

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In December, 1962, tlae autlaors happened to encounter 3 swinte cases of pseudo-tuberculosis which broke otut int Tottori city. Pasteurella pseudotuberculosis was isolatedfrom the liver, spleen, lurngs, duodenum, rectum, and mesenteric lymphnodes of thesecases.The main clinical findings were dullness, inappetence, blood-stained diarrlaea, andremarkable edema in the eyelids and their neighboring areas, the mandibla, and thelower part of the abdomen.Macroscopically were observed miliary grayish-white spots in the lixer, spleen, andmesenteric lymphnodes, enteritis catarrhalis and diphtheroides, swelling and grayish-white-macular formation in the mesenteric lymphnodes, dilatation of the riglnt ventricleof the heart, remarkable general edema, moderate increase of ascites, hydropericardium, and yellowisln coloration of the general adipose tissues.Microscopically, the following findings were characteristic. Tltere were purulentand necrotic foci containing baciJIary masses and surrounded by thin granulation tissues, that is, pseudotubercules, in the lungs, liver, spleen, mesenteric lymphnodes, and Nymph-follicles of the large intestiute. On the other hand, the liver presented cellular foci, some of which contained one or a few giant cells resembling Langhanss giant cells.Both pseudotubercular and cellular foci were present in the periphery of sorne acini.Consequently, it was considered that these changes had spread via circulatiout of theportal system. In the mesenteric lymphnodes, such pseudotubercular foci as observedin the liver and spleen were few, and necrotic areas with bacillary masses were spreadmostly along the peritrabecular and subcapsular sinuses. Therefore, it was presumedthat the change had been spread to the mesenteric lymphnodes via the lymphatic stream.In the colon and caecum where tlae diphtheroid change was present, the lymphfollicleswere hyperplastic and pseudotubercular foci sometimes formed in them.It was considered that loss of the resistance caused by general steatitis autd parasi-tism of Balanti

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Chicks were given 0, 3, 9, and 27 ppm of pyrimethamine contained in a diet for12 consecutive weeks and examined both clinically and histopathologically. The healingprocess of the pyrimethamine-induced Iesion was also observed.l. Clinically, chicks exhibited remarkable hyperchromic anemia and retardedgrowth after 27 ppm administration. They showed slight anemia after 9 ppm adminis-tration, but scarcely any after 3 ppm.2. Pathologically, cl?icks showed remarkable reduction in ertyhropoiesis in bonemarrow, lymphocytic decrease in all the lymphatic tissues and swelling of reticulum cellsafter 27 ppm administration. They showed medium reduction in erythropoiesis after9 ppm, and only slight damage after 3 ppm.3. Peripheral red blood cell count and hemoglobin value were lowered after Tweeks administration of 27 ppm, but were restored approximately to the initial level inl week. Histologically, however, erythropoiesis in the bone marrow and the Iesion oflymphatic tissues were not sufficiently cured within this period of time.4. It has become clear from these results that pyrimethamine, which is usuallyemployed for the prevention of Leucocytozoon caulleryi infection in chickens, willscarcely produce any damage on chicks in a dose of 3 ppm or below, even if it is admin-istered continually over a long period.

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