hypertension induces renal injury via decreased blood flow in the renal artery.
Voltage-gated, delayed-rectifier K+ (KV) channels play
key roles in the regulation of vascular tone, and their dysfunction in arterial
myocytes may be involved in the higher vascular resistance. In their report, Ogiwara et al. described that there is a large
contribution of KV2.1 to the resting tension maintenance of renal
artery in Dahl salt-sensitive hypertensive rats and suggested the up-regulation
of the KV2.1 channel in renal artery might be involved in the
compensatory mechanisms against decreased renal blood flow in salt-sensitive