The
SD-bw line, which was produced by recombination of
SD-72 with a
cn bw stock, shows fairly high
SD activity (K>0.9). This line was irradiated with a high dose of X-rays and many chromosome rearrangements were produced. The
SD activity was significantly reduced in many of the irradiated lines: in some cases, the original high activity was recovered in a few generations, while, in other cases, the reduction was permanent. The nature of the chromosome rearrangements was determined through recombination tests and cytological observation of the salivary gland chromosomes, and the results compared with the
SD activity. The findings from these experiments are as follows:
1. Only chromosome pairing in the
SD region corresponding to the small pericentric inversion of
SD lines is essential for the normal function of the
SD gene.
2. The Y chromosome may possess some function necessary for the
SD gene to operate.
3. There may be modifiers of
SD activity on the third chromosome and/or the fourth chromosome.
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