The short-tailed mutation (
T10r) induced by X-irradiation is allelic to the Brachyury (
T) on chromosome 17 of the mouse. Embryos homozygous for the
T10r are arrested developmentally at an earlier stage than
T/T embryos, but
T10r/
T embryos are indistinguishable from the
T/T. Serological studies suggest that the
T10r for may be a deletion. The present study examined genetic interaction of the
T10r and lethal
t-haplotypes (
tw32,
t1,
tw5,
tw18, and
tw1). The
T10r/
tn heterozygotes gave rise to viable tailless mice. Therefore, the
T10r is similar to the
T in interaction with recessive lethal
t-haplotypes. Lethality factors of such
t-haplotypes are mapped outside the abnormal region of
T10r.
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