In order to investigate the effects of anticartinogen on fungus infections, the inoculation was performed by intra-gastric instillation and intra-venous injection of spores of three kinds of fungi, Aspergillus fumigatus, Mucor spinescens and Cryptococcus neoformans, on female d-d mice, five weeks old and weighing twenty grams.
Nitrogen Mustard N-oxide was given intravenously, 1.5 mg. four days and 1.0 gm. two days prior to inoculation. The intragastric instillation of fungus spores was made with a needle inserted into the stomach cavity through the mouth. The intra-venous inoculation was done by the injection through the caudal vein with spore suspension.
The observation of survival days, recovery cultures from organs and pathological examination of tissues were performed.
In intra-gastric instillation experiment, no significant difference was found between control group and anticartinogen group in the death rate and positive culture recovery rate.
In intra-venous inoculation experiment, on the other hand, the death rate was higher in anticartinogen group than in control group in each strain of fungi. And, remarkable difference was found between the two groups in the death rate and positive culture recovery rate from brain, heart, liver, spleen, kidney, stomach and intestine, higher in anticartinogen given group.
From the result of the experiment, it is presumed that in the former, as the fungus infection does not yet established the lesions in any part of the animal tissues, anticartinogen can not exert its infection acceralating effect on the animals, to the contrary to the latter experiment.

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During the past several years, there has been an increase of interest in fungal infections of the central nervous system, but with regard to aspergillary infection in the brain, it is relatively uncommon. Consequently, the pathogenesis and morphological characteristics have not been clarified as yet, because of the paucity of the autopsy cases.
In this paper, the author tended to investigate the intracranial lesions of rabbits produced by intravenous injection of Aspergillus fumigatus. Acute lesions are usually manifested as rapidly spreading suppurative leptomeningitis, chorioditis and intracerebral abscesses which are initially formed around the cortical arterial branches with fungal embolism. Later on the inflammatory process spreads widely through the pia-glial or ependimo-glial membrane and is further extended by the confluence of multiple disseminated lesions. Circulatory disturbance also plays a role in the destruction of the brain tissue with or without remarkable inflammatory reaction. Besides suppurative or necrotic inflammatory lesions, proliferative or productive changes of glial or other mesenchymal elements are also encountered in a few examples, although these are usually localized. The neurons in the lesions are often compressed or destroyed by growing filamentous organisms, and this process is tentatively described as “mycotic neuronophagy”.

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