A case of toxic epidermal necrolysis (Lyell) appearing on 16 year-old male was presented. The patient was cured by various treatment with transfusion, intravenous use of corticosteroids and topical application of boric vaseline. Barbital was considered to be the causing agent by allergic examination tests. A brief discussion on this syndrome in Japan was described.

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A woman, age 32, came to the National Fukuoka Central Hospital because of a cutaneous condition that had begun twelve years previously, at the age of 20. The eruption caused no discomfort. Appearing first on the upper abdomen, the eruption abruptly spread to the chest, shoulders and back after she had been delivered of her first baby. There was no history of an antecedent eruption of any kind, and process had always been clinically noninflammatory. On physical examination, general health of the patient was good. There were numerous lesions on the abdomen, chest, shoulders and back. The lesions’ varied in size from that of a rice to a pea, and on the sides of the thorax were arranged along the lines of cleavage. There were two types of cutaneous lesions; one a soft, bladder like, circumscribed elevation of the skin, the other a flat, shriveled area showing neither elevation nor depression. All the lesions were lighter than the normal skin, some appearing gray. Histologically, there were a marked disruption and a diminution of elastic fibers. This case was diagnosed as macular atrophy of the skin (Schweninger-Buzzi type). This is supposed to be the eleventh case of this disease, reported in Japan. Authors discussed and compared these eleven cases in this report.

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The normal value of serotonin in whole blood was 0.077±0.022μg/ml and abnormally high values were observed in patients with skin cancer, pustular psoriasis, pemphigus vulgaris, and bullous pemphigoid. In patients with drug eruptions, serotonin had increased after administration of the offending drug and decreased to normal value before the drug eruption appeared. On the contrary, histamine increased in accordance with the appearance of the eruption. Corticosteroids inhibited the release of serotonin and prevented the appearance of drug eruption in oral administration test.

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The histological study was carried out on the series sections of 86 specimens obtained from 48 cases of pustulosis palmaris et plantaris, 1 case of trichophytia pompholytiformis, 3 cases of dyshidrosiform eruption, and 1 case of nummular eczema in a hand. The results obtained are as follows. Little or no spongiosis could be seen at the surrounding of its characteristic intraepidermal unilocular pustule. It seemed, therefore, that the histogenesis of pustulosis palmaris et plantaris was not eczematic reaction, but psoriasiform tissue reaction. The histological examination of epidermis showed such various findings as slight spongiosis and altération cavitaire in the suprapapillary regions, intraepidermal bulla and pustule. These changes in epidermis reflected the intensity of the inflammation in dermis. Severe inflammatory changes in dermis were observed in patients with pustule in epidermis. Inflammation in dermis was slight in patients with spongiosis and bullae in epidermis. The histological features of psoriasis, such as parakeratosis, elongation of rete ridges, thinning of suprapapillary portions of the stratum Malpighii, dilatation of the papillary capillaries also existed on the pustulosis, but these were not so distinct. It was assumed that the process of pustule formation might be as follows. The initial change of pustule formation was the degeneration and necrosis of the individual cells in stratum Malpighii. It might be caused by the invasion of the exsudate into the suprapapillary epidermis from the severe underlying inflammatory papilla. Leucotaxis occurred consequently, and then the spongiform pustule was formed. This change gave rise to characteristic unilocular pustule by continuous and strong exosersis. No relations between pustule or bulla and sweat duct was visible. The pustle of the 1 case trichophytia pompholytiformis could not be distiguished from the pustule of the pustulosis without detecting trichophyton in the horny layer by PAS stain. Dyshidrosiform eruption showed eczematic reaction. It was not the same as the tissue reaction of the pustulosis.

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A statistical study of the treatment of hemangiomas and keloids, containing preventive irradiation against the post-operative keloids, with “Dermopan” (Siemens) for recent five years in our clinic was reported. In total 551 cases, 150 cases could be followed up. Good results were obtained in 80 per cent (60/75) cases of hemangioma, in 54 per cent (27/50) cases of keloid and in 53 per cent (40/75) cases of preventive irradiation. The side effects, such as erythema, pain or erosion, were observed in 20 per cent (30/150) of cases. These results were given through the answers from the patients by request of our clinic.

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Von 1907 bis 1966 hatten wir im unsere Hautklinik die 1347 Hauttuberkulose Patienten diagnostitiert. Diese zahl sind 0.57% aller ambulants Patienten. Von 1907 bis 1916 batten die echte Hauttuberkulose Patienten gleich Ratio zum die Tuberkulid Patienten. Von 1957 bis 1966 hatte die Hinter ein Viertel zum die Vorder Im echte Hauttuberkulose Gruppe waren die Tuberkulosis verrucosa und Skrophuloderma allmählich abgenommen. Im die tuberkulid Gruppe waren Lupus miliaris disseminatus faciei und Erythema induratum Bazin Allmählich aufgenommen. Die echte Hauttuberkulose war mehr häufiger männlichen Geschlecht als beim weiblichen (1:0.68). Die Tuberkulid war mehr häufiger beim weiblichen Gesehlecht als m&aml;nnlichen (1:2.06). Aller Hauttuberkulose war mehr häufiger beim weiblichen Geschlecht als männlichen (1:1.36).

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Clinical effects of Glutide Tablets (glutathione reduced), Actoxal Tablets (pyridoxal-homocysteine) and concurrent use of both drugs were examined by double blind method on 77 cases with acute eczema, seborrheic eczema, contact dermatitis and drug eruption. It was found that Glutide Tablets and Actoxal Tablets were significantly more effective than the concurrent use of both drugs or placebo on these skin diseases. In general, the effects of Actoxal Tablets were more favorable than those of Glutide Tablets. Rash was improved better with the latter than the former, while alleviation of itching was more remarkable with Actoxal Tablets than Glutide Tablets. Glutide Tablets were markedly effective in contact dermatitis, but in acute eczema Actoxal Tablets were more effective than Glutide Tablets. Both drugs showed excellent effects in seborrheic eczema and drug eruption.

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