The antiviral effectiveness of commercially available povidone-iodine (PVP-I) products (isodine solution and isodine gargle) were investigated in vitro against animal coronaviruses such as transmissible gastroenteritis virus (TGEV), feline infectious peritonitis virus (FIPV), and bovine coronavirus (BCoV). These PVP-I products at the concentrations of general use showed strong antiviral activity against the coronaviruses used in the present experiments. These results suggest that hand washing and gargling with PVP-I products are a very useful defense against viral infection.

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A 6-year and 10-month-old, neutered female Labrador retriever was referred to our hospital with a month-long history of hematuria. Radiological and ultrasonographical examinations revealed a mass in the right kidney area. The mass was removed and investigated pathologically. Cystic wall composed of a thick capsule and a compressed renal parenchyma surrounded the mass. In cross section, it showed a grayish white mass like a cauliflower in the cyst. Tumor cells were spindle-shaped, and reacted with anti-vimentin antibody. In addition there were transitional epitheliums positive for anti-keratin/cytokeratin antibody, and myogenic cells positive to anti-desmin and anti-α-SMA antibodies. Based on these observations, this tumor was diagnosed as nephroblastoma, although primitive glomeruli and nephronic tubules were not observed.

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A 12-year-old male mixed-bred dog was brought to the Animal Clinical Research Foundation with anorexia and depression. Radiographs showed a spherical gas-filled viscus, which accorded with the shape and position of the gallbladder. A tentative diagnosis of emphysematous cholecystitis was made, and treatment with antibiotics was initiated. Twenty-four hours later, the gas shadow had disappeared. As gallbladder perforation was suspected, an emergency laparotomy was performed. The gallbladder was found perforated, and there was leakage of bile. Microbiological examination showed Clostridium spp. in the ascites. Histopathologically, the disease was determined to be necrotized cholecystitis. No complications were observed after surgery, and the quality of life was drastically improved for the patient.

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