Using liver biopsy specimens obtained from 55 dogs which had received surgical attenuation of a congenital extrahepatic portosystemic shunts, hepatic histopathologic findings were reviewed in relation to such clinical findings as age at diagnosis, presence or absence of clinical signs, shunt type, maximal diameter and total length of the shunting vessel, portal pressure before (baseline) and after ligation, change in portal pressure from the baseline, mortality rate following surgery, and survival rate. Histopathologic abnormalities (hepatocellular damage, dilatation of sinusoids, remodeling of the lobular structure, biliary proliferation, hypoplasia of intrahepatic portal veins, arteriolar proliferation, lipid granulomas, lymphangiectasis, and fibrosis) were classified, and the correlation between the histopathologic and clinical findings were statistically analyzed. The results showed that both hypoplasia of intrahepatic portal veins and dilatation of sinusoids were milder in older dogs. On the other hand, lipid granuloma formation was more extensive in older dogs. The hypoplasia of intrahepatic portal veins was severer in dogs with neurological abnormalities (seizure or ataxia) or delayed growth, in comparison with dogs with no apparent clinical signs. There was no significant correlation of the histological features examined here with shunt type, maximal diameter and total length of the shunting vessel, portal pressure between before (baseline) and after ligation, or change in portal pressure from the baseline. In dogs that died following surgery, hepatocellular damage, biliary proliferation, hypoplasia of intrahepatic portal veins, and lymphangiectasis were more extensive, as compared with surviving dogs. In conclusion, there was a significant correlation between the severity of hypoplasia of intrahepatic portal veins and such clinical signs as age at diagnosis, presence or absence of clinical signs, and mortality rate after surgery, which suggested that hypoplasia of intrahepatic portal veins might be the most correlative indicator of the clinical findings observed in dogs with congenital extrahepatic portosystemic shunt.
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