The accuracy in measuring total thyroxine concentration (tT
4) with a portable blood chemical analyzer (VetScan
®) was evaluated in healthy dogs. This apparatus has the advantage of doing multiple chemical blood tests at one time, requiring only 100μ
l of whole blood. Reproducibility tests were performed ten times for each sample from each dog. Dilution tests were also performed using physiological saline or serum of two different tT
4 concentration. The results of these tests showed excellent reproducibility and dilution reproducibility. As to the influence of interference substances, chyle was found to be the most influential. Since tT
4 values tend to be measured less than theoretical ones due to the presence of chyle, an improvement in this point might be necessary for future use. Correlation tests on tT
4 with the RIA method and the FPIA method were performed, and high coefficients were obtained between the values from the VetScan
® and those from the RIA method and from the FPIA method. From these results, VetScan
® could be considered useful for diagnosis by exclusion of hypothyroidism in an emergency or for monitoring during the administration of thyroid.
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