A case of 68 years old Japanese male was reported who was clinically diagnosed senile psychopathy and was found visceral Hodgkin's disease by autopsy. The disease involved thyroid, right kidney, spleen and lymph nodes.The brain showed no macroscopic and microscopic changes except simple atrophy.Generally, diffuse involvement of thyroid was rare condition.In this case, severe degree of diffuse fibrosis with scattered Hodgkin's cells was seen in the thyroid.It was suggested that senile psychopathy could be related to the diffuse involvement of Hodgkin's disease of the thyroid.

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An enzyme which catalyzes sulfhydryl disulfide interchange in proteins containing incorrect disulfide bonds has been reported by several investigators. In the present paper, the biological significance of glutathione on the interchange reaction to the randomly cross-linked RNase was determined. It was suggested that glutathione must be also involved in the rearrangement of the incorrect disulfide bond to form the correct disulfide bond of the corresponding native protein.

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Neutralization kinetic tests were carried out on nine type 2 and two type 1 strains. Seven type 2 strains had the similar antigenicities but other two strains were more or less different from them. KY showed the intermediate properties between type 1 and type 2 when anti-UW268 serum was used, while this strain clearly belonged to type 2 when tested with anti-KY or anti-KP-1 serum. Neutralizations by three anti-type 2 and two anti-type 1 sera revealed that KP-1 was neutralized slowly not only by anti-type 2 serum but also by anti-type 1 serum compared with other type 2 viruses tested. This means that KP-1 possesses special antigenic components differing from the other type 2 viruses.

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The rapid extraction method is obtained for simultaneously determing 5-HT and 5-HIAA in a single mouse brain, and can deal conveniently with up to 15-20 samples at the same time. Recovery of both indoles through the method was 75-85%, and the procedure can be applied routinely to the sensitive estimation of small amounts of 5-HT and 5-HIAA using ophthalaldehyde and L-cysteine for detection.

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Our findings deserve the following conclusions.1) With an initial dose of 0.1 to 0.15 mg/kg, sufficient and excellent muscular relaxation for endotracheal intubation can be obtained within 2 - 5 minutes after intravenous administration of pancuronium bromide in man.2) A large dose of 3 mg/kg in total was used to maintain controlled respiration under moderate hypothermia to treat a 6 year-old boy who had general convulsion and muscular twitching which accidentally occurred postoperatively after open heart surgery for ASD. In reference to this case, we noted none of the untoward reactions like tachyphylaxis or cumulative action and none of the untoward responses in the cardiovascular system.3) We did not experience the prolonged apnea which lasted more than two hours although a relatively large dose of pancuronium bromide had been used.4) Anti-hypotensive action was noticed on the hypotension due to halothane anesthesia, possibly with reference to the steroid type of chemical structure as suggested by Bonta.5) The preoperative complications such as mal-nutrition, anemia and renal impairment in cancer patients deserve special attention, that is, a larger dose should be avoided.Obviously much more clinical investigations about the effects of pancuronium as a neuromuscular blocker should be required before further precise conclusions can be drawn.

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We reported that the comparison of tumor affinity agents in experiment. The nuclides using tumor scanning have a distinctive character respectively. Then we should be considered sufficiently the distinctive character in taking tumor scintigram.

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Since we experienced an extremely rare case of metastatic basal cell carcinoma, the details of the case and literary considerations were described in this paper.

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In conclusion there was a definite difference in pathologic findings between the pulmonary hypertension due to ventilatory dysfunction and the postcapillary pulmonary hypertension due to heart disease. In the cases of the pulmonary hypertension due to lung diseases it takes longer for organic changes in the pulmonary vesseles, but, once the changes occur, they become, in most cases, irreversible and its critical level is also lower (Fig. 6). It can be considered almost hopeless when the pulmonary arterial pressure is more than 30 mmHg. In contrast, the organic changes occur quite rapidly in the postcapillary pulmonary hypertension with the severe congestion and thickning of alveolar walls and/or a high pulmonary arterial pressure.The ratio of pulmonary to systemic resistance, the cardiac index, histological changes of pulmonary arteioles at biopsy, and secondary changes of the alveolar wall seem to be quite useful in judging the reversibility of the pulmonary hypertension and in establishing indication for the operability of heart and lung surgery in severs cases in addition to the general surgical judgment.

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