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Volume 42, Issue 1
Displaying 1-7 of 7 articles from this issue
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HIROSHI HACHISUKA, NOBUHIRO YAMAMOTO, HIDEKI SAKIHAMA, YOICHIRO SASAI1995 Volume 42 Issue 1 Pages 1-8
Published: April 01, 1995
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSEpidermolysis bullosa is a group of inherited blistering diseases classified into three main sub-groups on the basis of the level of cleavage within the skin. In dominant dystrophic epidermolysis bullosa, characterized by cleavage below the basal lamina, two variants can be distinguished by the presence (Pasini form) or absence (Cockayne-Touraine form) of albo-papuloid lesions. The present study was undertaken to investigate the glycosaminoglycan chains of proteoglycans in the albo-papuloid lesions of a patient with the Pasini form, using histochemical and immunohistochemical methods. Histological examination revealed no dermo-epidermal separation. In the dermis, the papillary and subpapillary layers were slightly homogeneous, and exhibited a strong affinity towards alcian blue, which was abolished by treatment with chondroitinase ABC or in the presence of MgCl2 0.3M, but was resistant to digestion with streptomyces hyaluronidase. The papillary and subpapillary layers were intensely stained with a monoclonal antibody against small size proteoglycan with dermatan sulfate. These results suggest the presence of degraded dermatan sulfate proteoglycan in the papillary and subpapillary dermis of albo-papuloid lesions in the Pasini form of dystrophic epidermolysis bullosa.View full abstractDownload PDF (4518K) -
MICHIO SATA, TAKASHI MATSUSHIMA, SHINICHI KAKUMU, MASASHI MIZOKAMI, SH ...1995 Volume 42 Issue 1 Pages 9-20
Published: April 01, 1995
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSNatural interferon-γ at a dose of 0.5×106 or 1×106 IU daily was intramuscularly administered daily for 4 weeks to 15 patients with chronic hepatitis B. The efficacy and safety of the treatment were evaluated for 24 weeks following the completion of the 4-week treatment period. Persistent disappearance of HBeAg was observed in 5 of 15 patients. Serum hepatitis B virus (HBV)-related DNA polymerase disappeared in 5 of 13 patients at the end of interferon therapy. On the other hand, serum ALT and β2-microglob-ulin levels showed a significant increase during the interferon therapy period. The side effects were completely reversible. These findings suggest that interferon-γ has an antiviral effect in patients with chronic hepatitis B and that the main mechanism of the therapeutic effect may be associated with the elimination of HBV-infected hepatocytes due to the immunopoten-tiating effect of the substance.View full abstractDownload PDF (5188K) -
SHINYA SUMIDA1995 Volume 42 Issue 1 Pages 21-32
Published: April 01, 1995
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe β-2 integrin consists of lymphocyte function-antigen-1 (LFA-1, CD11a/CD18) which binds to the major ligand intracellular adhesion molecules 1 and 2 (ICAM-1 and ICAM-2), Mac-1 (CDllb/CD18, ligand iC3b) and p150, 95 (CDllc/CD18, ligand iC3b). These molecules function not only as adhesion molecules but as signal transduction agents. To investigate the expression of an integrin family in asthma, lymphocyte subsets were assessed using bronchoalveolar lavage fluid (BALF) cells obtained from asthma patients. The relationship between the integrins and lymphocyte subpopulations and their activation state in the BALF was analyzed using two-color flow cytometry in 15 subjects with asthma and in 13 control subjects with chronic bronchitis. The absolute number of CD11a+ CD4+ lymphocytes was significantly greater in the asthmatics than in the non-smoking subjects with chronic bronchitis. In the asthmatics, the expression of the CD11a+CD4+ lymphocytes was significantly higher than the expres-sion of CD11a+CD8+ lymphocytes. The CD2+ lymphocytes had a significant positive regression with the CD11a+ CD4+ lymphocytes in the asthmatics. These findings indicate that the CD11a+ antigen is mainly located on the CD4+ lymphocytes in asthmatics, and that the subset of CD11a lymphocytes with the CD4+ antigen increases as the absolute number of T lymphocytes increases. Analysis of BALF revealed the representation of integrins for the ongoing bronchial transfer of information, and may provide an approach to obtain evidence about the inflammatory processes on the surface of the bronchioles in asthma.View full abstractDownload PDF (1393K) -
Postoperative ComplicationsKAZUO SHIROUZU, HIROHARU ISOMOTO, TATSUHISA MORODOMI, YUTAKA OGATA, YO ...1995 Volume 42 Issue 1 Pages 33-37
Published: April 01, 1995
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThis study was designed to clarify the postoperative major complications of total pelvic exenteration for locally advanced colorectal cancer. Twenty-six patients (primary disease: 17, recurrent disease: 9) were retrospectively studied. Major complications developed in 30.8% (8 of 26); in 23.5% (4 of 17) for a primary disease and in 44.4% (4 of 9) for a recurrent disease. Only 2 patients (7.7%) died within 30 days after the operation; one patient died of hepatic failure and another of pelvic sepsis. Postoperative ileus developed at a high rate of 11.5% (3 of 26). Ileo-ileal anastomotic leakage developed at a rate of 7.7% (2 of 26) and it commonly occurred following irradiation. The remaining one patient had gastrointestinal bleed-ing. These 6 patients surviving the operation were successfully managed conservatively. Conclusion was as follows: Total pelvic exenteration should be performed carefully and aggressively regardless of the development of postoperative complications.View full abstractDownload PDF (640K) -
KEIKO ODA, SHINITIRO OKI, NAOKI TSUMURA, MITUYOSHI NAKAO, TAKASHI MOTO ...1995 Volume 42 Issue 1 Pages 39-44
Published: April 01, 1995
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTo investigate the natural course of viral shedding during the newborn period, the presence of Cytomegalovirus (CMV) DNA in specimens at 3, 7, 14, 21 and 28 days of life was examined using the polymerase chain reaction (PCR) method. At the 3rd day of life, the viral DNA positive rate in the urine was 7% (4/60), at the 7th day 7% (3/46), at the 14th day 10% (2/20), at the 21st day 10% (1/10), and at the 28th day 25% (1/5). CMV was also detected in samples co-cultivated with HeLa 229 cells and this positive rate was 5% (3/60). The viral positive rate in newborns did not correlate with the gestational age, body weight, or serum IgM level. Six congenital infection cases were identified; two of which were small-for-date babies (SFD) and three of which were born with premature rupture of membranes (PROM). They had no complications during the six months after birth.View full abstractDownload PDF (1977K) -
TOSHIHIKO NISHIMURA, TAKASHI AKASU1995 Volume 42 Issue 1 Pages 45-48
Published: April 01, 1995
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (447K) -
TAKASHI AKASU, MASARU ISHIMATSU, KEI YAMADA1995 Volume 42 Issue 1 Pages 49-53
Published: April 01, 1995
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (579K)
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