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Volume 11, Issue 3
Displaying 1-5 of 5 articles from this issue
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MUTSUYA TAKEUCHI, EIJI KIMOTO, YUKIO TANAKA1964 Volume 11 Issue 3 Pages 107-121
Published: March 15, 1965
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSInterest in the ground substance of vascular structures has been evoked by the advancement of histo-pathological studies on the atherosclerosis, emphasizing the possible role of mucopolysaccharide accumulation in the production of focal atheroma. Such histochemical observations on arterial mucopolysaccharide have stimulated the extension of the biochemical knowledge on their nature and metabolim. The questions were reviewed from the recent informations including some of our studies concerned. Our experiments at the first step were carried out on the gross aortic materials to overlook the changing pattern of total and fractionated AMPS with aging and atherosclerosis. At the next step, further microtechnique was introduced to permitting the analysis on the aortic material comprising as small as one intimal lesion, which was composed of the microscale extraction procedure including the selective precipitation with cation detergent and the densitometric determination of AMPS fractions after electrophoretic separation on cellulose acetate strip. The experiments have evidenced the facts that aging of aortic tissue appears to be characterized by a decline of total AMPS contents in aceton-dry tissue and a decrease in hyaluronic acid and chondroitinsulfate A or C content and an increase in chondroitinsulfate B, similarly to the aging skin or cartilage, and that the edematous lesions, perhaps an early phase of fibrous plaque, comprise both high AMPS value and hyaluronic acid content. The possible biological functions of AMPS on atherogenesis were also reviewed from the recent publications. AMPS was recognized to possess the properties of preventing thrombus formation and lipid deposition in the arterial wall through its antithrombin and lipid clearing activity and, on the other hand, those of inducing the fibrin and lipid deposit through physicochemical complex formation with fibrinogen and lipoprotein. The destruction or abnormal aggregation of AMPS in the ground substance might cause an increased permeability of the arterial wall to the circulating lipoprotein and also the destruction of connective tissue fibers, substantially inducing the atherosclerosis.View full abstractDownload PDF (6269K) -
KENICHI NODA1964 Volume 11 Issue 3 Pages 122-132
Published: March 15, 1965
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSIt is the main purpose of this report to elucidate the movement of K ions (particularly net efflux) in connection with water movement. 1. When water moved osmotically across the plasma membrane, K net efflux, independent of water movement, could be observed. 2. When the muscle was transferred from distilled water or sucrose to K free Ringer, the transient increase in K net efflux in K free Ringer was observed and was two or three times the K efflux which was increased in distilled water. The transient increase in K efflux had no close relation with total [K]i. The [K]i was not the primary cause for K net efflux. The total [K]i obtained with flame-photometer did not immediately signify the driving force for K net efflux. 3. The shorter the time of interrupting immersion with Ringer in moving from distilled water, sucrose, or K free Ringer to K free Ringer, the larger was the rate of increase in K efflux during the following soaking with K free Ringer. The transient increase in K efflux became less with approaching to the balanced state of K ions in Ringer; in other words, high [K]i, on the contrary, tended to inhibit the K net efflux. 4. The increase in K efflux from a transversely cut section of the muscle did not result from higher [K]i and was not the immediate cause for the decrease in [K]i. 5. Considering from the viewpoint of homeostasis, K net efflux described here may be a subordinate molecular phenomena at the membrane.View full abstractDownload PDF (1032K) -
RYOHEI M. OGURA1964 Volume 11 Issue 3 Pages 133-138
Published: March 15, 1965
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSOne of the most important functions of the epidermis is to protect underlying tissue from the environment. Only a few biologically active ultraviolet wave length of sunlight penetrates the epidermis into the dermis. However, an exposure to intense ultraviolet light produces a number of biochemical alterations. Most of the effect of ultraviolet light of the skin are harmful instead of beneficial. The exposure of ultraviolet is a major cause of cancer of the skin.The metabolism of sulfur compound in the epidermis is a challenging subject, because of its fundamental relationship to cellular biochemical activities. This report presents data and discusses the conparatively long term effects of ultraviolet lihgt on the sulfhydryl compounds in living rat epidermis.View full abstractDownload PDF (569K) -
MASAYA NISHIMURA, HIDETO MASAKI, MOTOICHI AKAO, HIROMI TAKAKI, TATSUJI ...1964 Volume 11 Issue 3 Pages 139-143
Published: March 15, 1965
Released on J-STAGE: June 17, 2010
JOURNAL FREE ACCESSRecent developments in cardiac surgery have been followed by increases in the number of open-heart operations which require an artificial heart-lung machine. As a result, diluted blood in the extracorporeal circulation has been utilized because of the increasing requirements for fresh blood and in order to reduce side-effects. Since 1960. Neptune, Cooley, De Wall, Zuhdi, etc. reported the complete replacement of blood with blood substitutes, such as 5% glucose in distilled water, physiological saline solution or low-molecular weight dextran, to prime the circuit of the artificial heart-lung machine. Then improvements in and simplification of the oxygenator have been made. With this thought in mind, the authors have developed a simplified disposable oxygenator and have obtained good results in its clinical use. The details and indications for the utilization of this machine follow.View full abstractDownload PDF (1874K) -
MASAHIRO NAKAMURA, SHINYA MURAOKA, TSUNEO KINOSHITA1964 Volume 11 Issue 3 Pages 144-147
Published: March 15, 1965
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSIn order to contribute toward the experiments of pure culture and tissue culture of Myc. lepraemurium, biological and biochemical properties of the bacillus have been investigating and the data obtained had reported (1, 2). This communication describes the effects of physical treatments on the infectivity of the bacillus.View full abstractDownload PDF (309K)
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