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Volume 21, Issue 1
Displaying 1-5 of 5 articles from this issue
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AKIRA TANIMURA, HIDEO YAMAMOTO, TATSUO YAMAGUCHI, HIDENORI SHIBATA, TE ...1974 Volume 21 Issue 1 Pages 1-6
Published: June 25, 1974
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA case of 70 year old Japanese female who had primary leiomyosarcoma of duodenum was reported. The most distinctive feature of this tumor was the presence of cytoplasmic hyaline globules in tumor cells. These hyaline globules were intensely PAS positive and hyaluronidase digestive. Electron microscopically, hyaline globules were found in distended cisternae of r-ER system. From these observation, hyaline globules were suggested to be mucopolysaccharide-protein complex, especially hyaluronic acid.View full abstractDownload PDF (9013K) -
ISAMU MATSUMOTO1974 Volume 21 Issue 1 Pages 7-9
Published: June 25, 1974
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (1300K) -
OVARIAN TUMORS DEVELOPED IN RATS RECEIVING CHEMICAL CARCINOGEN 9, 10-DIMETHYL-1, 2-BENZANTHRACENETOSHI KATO, MICHIAKI YAKUSHIJI, AKITSU TSUNAWAKI, KAIKITSU IDE1974 Volume 21 Issue 1 Pages 11-19
Published: June 25, 1974
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThere are numerous studies that have been published concerning experimental production of ovarian tumors in laboratory animals with the chemical carcinogen 9, 10-dimethyl-1, 2-benzanthracene (DMBA) and close investigations are in progress on the histogenesis and endocrinologic characteristics of the ovarian tumors induced with this compound. In the previously reported studies, the chemical carcinogen had been applied topically or administered by intravenous route and the neoplasms thereby produced were in most instances granulosa cell tumors, whilst it may fairly be said that reports of production of adenocarcinoma which is of profound interest to us clinicians because of its significant incidence in women as yet are essentially nonexistent. The present investigation represents an experimental attempt to study ovarian tumors induced with DMBA applied by the clipping method which had not been tried by any investigator in the past. There was, as a consequence, solid tumor formation in 36 out of 70 animals (51.4%) in 50 weeks of DMBA application and it is suggested from the data obtained that solid tumors are produced in the ovary with an incidence as high as approximately 70 per cent during the period from 41 to 50 weeks of application. This solid tumor incidence is about four to five times as high as the previously observed one with 20-methylcholanthrene. Moreover, it is considered to be of great significance from the viewpoint of experimental oncology that the solid ovarian tumors produced were of adenocarcinoma type in 18 of the 36 cases.View full abstractDownload PDF (10615K) -
KEN YAMAGAMI, MICHIAKI YAKUSHIJI, KAIKITSU IDE, HIROSHI SHIMOMURA, AKI ...1974 Volume 21 Issue 1 Pages 21-22
Published: June 25, 1974
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA case of cervical pregnancy meeting the four criteria of Rubin. There is no case on record of a cervical pregnancy going to term.View full abstractDownload PDF (1302K) -
TOSHI KATO, MICHIAKI YAKUSHIJI, AKIO ARIMA, ITSUO HARA1974 Volume 21 Issue 1 Pages 23-33
Published: June 25, 1974
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSEffects of estrogen and progesterone were investigated in rats with particular reference to morphological changes of the endometrium, using commercially available estrogen and progesterone preparations, with the results which may be briefly summarized as follows: 1. Eighty-five (74%) of a series of 115 rats treated with estrogens showed infranuclear vacuolation of the endometrial glandular epithelium. This microscopic feature seems to serve as a reliable morphologic index to endometrial response to estrogen priming. 2. A histologic change suggestive of squamous type metaplasia was considerably high in incidence in the endometrium of the uterine horns of estrogen-treated rats. That no reserve cell-like cells were found in the region of transformed epithelium where glandular epithelial cells were noted to be enlarged and flattened with contiguous squamous epithelium-like cells, suggests a direct metaplasia of endometrial epithelia of the corn uteri. 3. Estrogens have proven to increase the permeability of capillary blood vessels. 4. Administration of a progesterone preparation failed to bring about any conspicuous endometrial change in animals primed with estrogen or in those without estrogen priming, under the described experimental conditions.View full abstractDownload PDF (14321K)
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