Biochemical studies concentrating on a paper electrophoretical analysis were made with the following results on the synovial fluid in an attempt to make a diagnosis of arthropathy.
1. The amount of protein was greater than that in a control group and was proportional to the intensity of the inflammation.
2. The severer the inflammation was, the lower was the viscosity of the synovial fluid. The viscosity indicated the local findings well.
3. The flocking number reaction (Takata) and particularly the mat delayed reaction were of value in observing the course of diseases.
4. Although the Tokata reaction, the Chinin reaction and the cadmium reaction did not occur in the synovial fluid the clinical significance of the Weltmann's coagulation band for serum was recognized.
5. A marked increase in mucoprotein took place in patients blood serum with rheumatosis. This finding was of significance in following the course of the diseases.
6. No changes between the types of disease took place in alkali phosphatase and in inorganic substances Na, K, P and Ca.
7. Amarked decrease of A/G ratio was observed in rheumatoid arthritis which was proportional to the intensity of inflammation.
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