Serum proteinase inhibitors such as C
1S-inhibitor (C
1S-INH), α
1-antitrypsin (α
1-AT), antithrombin III (AT-III) and α
2-macroglobulin (α
2-M) were measured in 156 patients with malignant tumors of various organs.
Results;
1. Generalized findings in all patients examined: C
1S-INH and α
1-AT increased and AT-III decreased as the stage of tumors progressed. A significant increase of α
2-M was found exclusively in the male patients, but changes became unremarkable following the progression of illness.
2. Changes in each patient group with tumors of different organs: (a) α
2-M significantly increased also in the female patients in advanced stage of cancer of the lungs. (b) AT-III rather increased in cancer of the cervix uteri. (c) α
2-M significantly increased even in earlier stage of cancer of the urinary bladder. (d) AT-III remarkably decreased in cancer of the prostate.
These changes of serum proteinase inhibitors are assumed to contribute beneficial environment for the growth of tumors.
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