生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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通巻352号
選択された号の論文の16件中1~16を表示しています
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  • 能瀬 聡直, 高坂 洋史
    2020 年 60 巻 6 号 p. 319-324
    発行日: 2020年
    公開日: 2020/11/28
    ジャーナル フリー

    Selecting and executing specific behaviors in response to various environmental stimuli is a fundamental function of the nervous system. In this review, we introduce larval Drosophila as a model to study this process. We first review recent technological innovations in this system that allow cellular-level functional dissection of the central circuits, such as systematic single-neuron genetic targeting, all-optical neurophysiology and connectomics. We then introduce our recent studies on the structure and function of neural circuits that regulate forward and backward locomotion of the larvae. Taken together with the statistical analyses of the populational activity dynamics and mathematical modeling, system level understanding of the operation of the neural circuits is becoming possible.

  • 古賀 理恵, 古賀 信康
    2020 年 60 巻 6 号 p. 325-330
    発行日: 2020年
    公開日: 2020/11/28
    ジャーナル フリー

    Protein design holds promise for applications such as control of cells, therapeutics, new enzymes and protein-based materials. Recently, rational design of protein molecules has made a great progress, guided by the consistency principle proposed by Nobuhiro Gō in 1983: local and non-local interactions consistently favor the same folded conformation. We discovered a set of rules for designing ideal protein structures stabilized by consistent local and non-local interactions. The rules enabled the de novo design of amino acid sequences having the funnel-shaped energy landscapes toward the desired target structures. Various ideal protein structures have been created using the rules.

  • 熊本 康昭, 藤田 克昌
    2020 年 60 巻 6 号 p. 331-337
    発行日: 2020年
    公開日: 2020/11/28
    ジャーナル フリー

    Raman microscope is not widely used in life sciences. This fact is attributed to the fundamental weaknesses of Raman imaging, i.e., signal weakness and difficulty in molecular identification upon a cell spectrum. Signal weakness leads to long data acquisition time in Raman imaging. We discuss the recent advances in Raman microscopy for accelerating data acquisition speed. Difficulty in spectrum interpretation is attributable to spectral overlapping of vast kinds of molecules existing in a biological sample. We present Raman tags that have characteristic spectra in the silent region, where little intrinsic cellular signal appears. We also present super-resolution techniques that can aid the spectral complexity.

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