2005年11月～2010年7月までに，縦隔型リンパ腫と診断した猫10例に，犬のUniversity of Wisconsin-Madison chemotherapy protocol（UW25）に準じたプロトコールを行い，完全寛解率，生存期間ならびに抗癌剤の副作用について調査した。完全寛解率は90%と非常に高く，生存期間は1年未満が6例（現在生存中1例含む），1年以上2年未満が1例（現在生存中），2年以上3年未満が1例（現在生存中），3年以上が2例（現在生存中1例含む）と長期の生存期間が得られた。副作用の程度は軽度であり対症療法により回復した。このプロトコールでは25週の治療期間中に再発がみられなかった場合，過去のCOP療法の報告と比べ非常に長期の生存期間が得られることが証明された。
Objective : Since the sensitivity to prostacyclin differs widely depending on the animal species, it is essential to investigate the dose setting from the safety point of view before using beraprost (BPS) in diseased cats. Design : One week multiple administration toxicity study of BPS (10, 30, 70, 100 μg/kg, twice a day) compared with vehicle as control. Procedure : BPS group (n=6) at 10, 30, 70 and 100 μg/kg and vehicle group (n=5) were administered to healthy cats twice a day for 7 days. Both in BPS and vehicle groups, cessation period of the drug was provided 2 weeks between each doses of BPS. In addition hemodynamic parameters were also noted at 0.5 hour before initial administration on the first day and at 1 hour after final administration on the 7th day of each dose of BPS and vehicle. Results : Though BPS from 30 μg/kg upward transiently and dose-dependently increased the heart rate but had no influence on the blood pressure. Compared with the vehicle group, serum creatinine slightly but significantly decreased at 70 and 100 μg/kg and this decrease was also significant against the pre-administration value at the same dose. The influence of BPS on the blood parameters was nil or negligible, if any. Diarrhea were sporadically noted at 70 μg/kg, and mild and transient vomiting and sedation occurred at 100 μg/kg. However, each symptom soonerly disappeared without treatment. Conclusion : The pharmacological action and types of adverse effects of BPS in the cats were almost similar to those observed in other animals and the repeated oral administration of BPS can be safely conducted in cats at least up to 30 μg/kg twice a day.