生物物理化学
Online ISSN : 1349-9785
Print ISSN : 0031-9082
ISSN-L : 0031-9082
13 巻, 2 号
選択された号の論文の3件中1~3を表示しています
  • 1968 年 13 巻 2 号 p. 81-157
    発行日: 1968/02/29
    公開日: 2009/03/31
    ジャーナル フリー
  • 日本脳炎の疫学的研究 第12報
    緒方 正名, 長尾 寛, 北村 直次, 菊井 立子
    1968 年 13 巻 2 号 p. 159-162
    発行日: 1968/02/29
    公開日: 2009/03/31
    ジャーナル フリー
    We could obtain the chiken by artificial fertilization from the hen (White Leghorn) having hemagglutination-inhibition antibody induced by natural infection of Japanese encephalitis. And the rates of disappearance of maternal antibody in chickens were examined.
    The results obtained were as follows.
    1) Linearity of the semilogarithmic plots of antibody titer in the chicken against the time was proved.
    2) Hemagglutination-inhibition titer of maternal antibody at the time of hatch as obtained by extrapolation was about 1:600. The value was the same as that of maternal hen.
    3) A half life of hemagglutination-inhibition antibody in the chicken was proved to be 4 days.
    4) Hemagglutination-inhibition antibody in the chicken was proved to exist mainly in γ-globulin fraction by starch block electrophoresis.
    5) From the above results we must take chicken into consideration as an amplifier of Japanese encephalitis virus.
  • 第II報 血清免疫グロブリンの疾患時変動
    戸田 武二
    1968 年 13 巻 2 号 p. 163-172
    発行日: 1968/02/29
    公開日: 2009/03/31
    ジャーナル フリー
    Serum levels of three classes of immunoglobulins (IgG, IgA, IgM) in pathological conditions were measured by quantitative precipitin reaction using class specific antisera.
    Increases of three classes of immunoglobulins were found in chronic liver diseases, rheumatoid arthritis and malignant lymphoma so far investigated.
    Liver cirrhosis had the higher level of IgG than chronic hepatitis. In histological studies on liver biopsy specimens, IgG was shown to have a correlation with hepatic fibrosis, hepatocyte degeneration and mesenchymal reaction. In acute hepatitis IgA and IgM were elevated, but IgG was within normal limits. A patient with Rotor's syndrome had an increased IgA and a slightly elevated IgM with a low IgG level.
    Systemic lupus erythematosus showed an increase of IgG and IgA with normal or slightly decreased IgM.
    In nephrotic syndrome all three classes of immunoglobulins were reduced with the less decrease of IgM.
    In monoclonal gammopathy, the anomalous protein showed the highest level of corresponding immunoglobulin class and the remaining immunoglobulins were usually decreased, while in Bence Jones proteinemia, all immunoglobulins were within normal range.
    In cases of acute leukemia treated with corticosteroid, three classes of immunoglobulins were decreased, though chronic myelogenous leukemia showed a normal IgG and a slightly elevated IgA with a reduced IgM level.
    In agammaglobulinemia all three classes of immunoglobulins were most conspicuously decreased. Five cases of ataxia teleangiectasia showed a selectively low concentration of IgA. In these cases IgG levels were normal or slightly reduced with elevated IgM levels.
    Pathophysiological meanings of these findings have been discussed with special reference to metabolic behaviours of each class of immunoglobulin under the conditions described.
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