The purpose of this study is to evaluate hemostatic effect of the mouthwash containing tranexamic acid (TR) which is known as a hemostatic and antiinflammatory drug.
The hemostatic effect was studied by the modification of bleeding method with the peritoneum of a rat on the three kinds of test solution; mouthwash containing TR, blank solution (mouthwash without TR) and control (purified water).
The following results were obtained;
1) Hemostatic effect of the mouthwash containing TR could be evaluated by the modification of bleedind method with the peritoneum of a rat.
2) It was recognized that hemostatic effect of the mouthwash containing TR was remarkably stronger than control at 30min. after administrations.
3) The blank solution showed anti-hemostatic effect, which was presumably due to the effect of the ingredients contained in the solution, such as surface active agents, perfumes, antiseptic agents and so on.

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The structure of eye and lashes is individual variations. Our evaluation and taste for mascara are greatly affected by that structure. It's necessary to make the system of conformity with individual eye and lashes, for the good choice of mascara.
First of all, we checked up the structure of eye and lashes, such as the number, length and direction of eyelashes, the width of eye and so on. Next, we investigated the influence in sensory evaluation and taste for mascara caused by difference of structure. Lastly, we tried to correspond to different types of mascara.
The result was that there are individual variations in the length and number of eyelashes rather than eye, no difference between men and women.
Three major items as follows were important factors of the finishing and taste of mascara. They were “the length of eyelashes”, “the amount of eyelashes” and “the width of eye”, We could classify persons into seven groups according to these three items, who evaluated four types of mascara.
In the usage test, we could select the best of four types of mascara for seven groups with different style in their eye and lashes.

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It is reported that squalene hydroperoxide, which is the primary peroxide of squalene, is produced by exposing skin to sunlight. Using squalene hydroperoxide as a marker, we studied inhibitory effects of some antioxidants on lipid peroxide production of sunlight exposed skin. Each ethyl-acetate solution of purified squalene and an antioxidant mixture was applied on the forehead skin, and exposed to sunlight. By specific detection of squalene hydroperoxide using the chemiluminescence-high performance liquid chromatography system (CL-HPLC), the peroxide value of exposed samples could be determined. dl-α-Tocopherol was more effective than BHT.

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Effects of ethanol, polyol and oil in cosmetics on stability of methyl paraben (MP) have been studied. MP was degraded by both hydrolysis and transesterification in the presence of alcohol or polyol. In ethanol or 1, 3-butylene glycol aqueous solution, observed rate constant (k) for degradation of MP increased with water activity (Aw) rising. k was nearly equal to rate constant for hydrolysis. This indicated that transesterification was negligible in these solutions. In glycerin aqueous solution, k increased as Aw rised. At Aw=0.95, k took a maximum value, and above this k decreased. This result suggested that the contribution of transesterification was significant in this solution.
In two-phase oil oil-water systems, MP is partitioned into oil and water. MP underwent degradation only in water phase, then transferred from oil phase. Consequently, partition coefficient (P) remained constant. P is determined by kind of oil, and related to pKa of MP and pH. We found that a plot of k versus logP gave a straight line, and that the slope was dependent on the amount of oil. In aqueous solution, k was related to pH and temperature. From these results, we proposed an equation with which residual proportion of MP was estimated. In emulsion system, this equation did not explain the behavior of MP. We obtained another equation leaving the transfer of MP out of consideration.
The calculated values agreed with experimental results. This suggested that in this system no MP transferred from oil phase because of some components which interferred with transfer of MP.

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The product performance of cosmetics is determined mainly by the sensory evaluation of users, and the objective measuring method and equipment to measure it haven't yet enough established. We applied KES-SE measuring instrument to the objective measuring method for evaluating the hand touch feeling of cosmetics.
In this study, we focused on the massage cream, especially whose hand touch on the skin surface is the decisive factor to determine the product performance among various cosmetics. As for the physical property, we used KES-SE measuring instrument and derived the coefficient of friction (MIU) and mean deviation of MIU (MMD) when massage creams are applied on an artificial leather. And, we measured the compressional force and energy, and stress alleviation of the hand touch feeling of creams, using KES-G5 (HANDY MOTION) Finger Robot Arm Motion Instrument. We examined the correlation between these measuring data and the result of the sensory hand evaluation test performed by aestheticians, such as the spreadability, permeability, smoothness, and stickiness of creams. The correlation between each physical property value and the sensory evaluation value differ according to various measuring conditions, varying application quantity, area of cream, number of times of the reciprocation action and load of contactor. And MIU of cream with application quantity 0.05ml and load 30gf showed a correlation with the result of the sensory hand evaluation of spreadability, permeability, and smoothness of creams. MIU of cream with application quantity 0.1ml and load 50gf showed a correlation with stickiness. And the compressional properties showed a good correlation with softness and skin touch feeling of creams.
As the results, we confirmed that we could grasp the hand touch feeling of massage creams by physical quantity, using the objective measuring method.

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The use of hydrogen peroxide produced in enzymatic oxidation has been investigated for oxidative hair dyeing and permanent waving.
For enzymatic oxidations were used pyruvate oxidase, lactate oxidase, glycerol oxidase, xantine oxidase, uricase and pyranose oxidase.
Successful dyeing of goat hair was carried out using uricase and pyranose oxidase in a commercial hair dyeing formulation with p-phenylenediamine.
An uricase produced the maximum hydrogen peroxide concentration up to about 0.06% after 5min. of reaction at pH 7.0.
Effect of enzyme on hair waving was estimated according to Kirby method.
Results on waving efficiency and wave retention ratio showed that permanent waving with uricase is almost on the level of chemical method with sodium bromide.

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