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Volume 31, Issue 2
Displaying 1-15 of 15 articles from this issue
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II. Pulmonary Lesions in Rabbits Infected with Schistosoma japonicum.MINORU MIYASATO, YUHJI KAKIZOE, HIROKI IIDA, YOICHI HIRANO, HIROSHI TS ...1984 Volume 31 Issue 2 Pages 47-53
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA total of 65 rabbits were infected with Schistosoma japonicum. The lungs were examined 48 to 400 days after the infection and pathologically classified into four categories according to the extent of the pulmonary lesions. Both parenchymatous and vascular pulmonary lesions were generally found to have a focal distribution. The quantity of eggs in the lung tissue corresponded to the extent of the pulmonary lesions, and both were related to duration of the infection. It was concluded that the extent of the pulmonary lesions can be attributed to a gradual accumulation of egg emboli in the lung and the protraction of the infection. Diffuse pulmonary lesions leading to cor pulmonale only rarely occur.View full abstractDownload PDF (6747K) -
SHIGERU YAMAMOTO, HIDEFUMI KABUTA, YASUHIRO UCHIWA, TATSUHIKO NAKAGAWA1984 Volume 31 Issue 2 Pages 55-63
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSMixed infections of cells with pairs of r mutants (mutants defective in fusion function) of herpes simplex virus types 1 and 2 resulted in the cytopathic change of cell rounding (no complementation) and did not produce the recombinant, which formed a large syncytium due to cell fusion (no recombination). No complementation was observed in the superinfection after various times with heterologous r mutant and also in mixed infections with three r mutants, two belonging to separate complementation groups of one type and one of the opposite type. These observations led to the hypothesis that some gene (s) involved in r mutant and in fusion-causing virus encode an inhibitory factor against cell fusion caused by the heterologous type virus.View full abstractDownload PDF (5350K) -
MIZUKI HIRATA, MINORU MIYASATO, HIROSHI TSUTSUMI1984 Volume 31 Issue 2 Pages 65-71
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe effect of a hydrochloric acid solution on the circumoval precipitin (COP) reactivity of Schistosoma japonicum eggs was studied. When eggs, recovered by trypsin digestion from tissues of an 8 week-infected rabbit, were treated with a pepsin HCl solution, they had significantly higher reactivity than the saline-treated eggs (control). A similar effect was obtained with HCl solution (0.008 N), alone. In contrast, a sodium hydroxide solution (0.05 N) decreased the reactivity. Treatment with different concentrations of HCl (0.01 to 6N) for 2 days revealed that the reactivity was highest at 0.1 N, and was diminished by the higher concentrations (3 and 6N). Preservation in an HCl solution (0.01N) yielded a peak reactivity at 2 days. While the exact role of the HCl solution was not studied, this study contributes to the preparation of egg specimens and to our understanding of the low reactivity of eggs.View full abstractDownload PDF (772K) -
Its Dianostic Value in Neoplasms of the Central Nervous SystemMASAFUMI YOSHIDA, YUHKI OHSHIMA, KAZUHIKO MORITAKA, SHINKEN KURAMOTO1984 Volume 31 Issue 2 Pages 73-79
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSCarcinoembryonic antigen (CEA) in cerebrospinal fluid (CSF) and plasma was measured with commercially available radioimmunoassays from 19 patients with neoplastic conditions of the central nervous system (CNS); 5 metastatic brain tumors, 4 glial tumors, 4 meningiomas, 2 pituitary adenomas, 2 acoustic neurinomas, 1 malignant lymphoma and 1 choriocarcinoma. 27 patients with various non-neoplastic conditions served as control. In the control group, CSF CEA value was 0.8±0.3 ng/ml (mean ± s. d.). In metastatic brain tumors, two cases showed an elevation of CSF CEA and another case showed borderline elevation of CSF CEA. In metastatic brain tumors, elevation of CSF CEA seemed to be well established and of great diagnostic value provided the primary malignancy is capable of producing CEA. In glial tumors, CSF CEA was elevated in only 1 case, in which elevation of CSF CEA preceded recurrence of the tumor. In glial tumor, measurement of CSF CEA seemed to be of value in evaluation of post-treatment patients, however, this point has yet to be established. No significant elevation of CSF CEA was noted in any other neoplastic condition. Significance of CSF CEA in diagnosis and management of CNS neoplasms is discussed.View full abstractDownload PDF (845K) -
MINORU SHIGEMORI, TATSUO YUGE, TAKASHI TOKUTOMI, FUMIHITO YAMAMOTO, TA ...1984 Volume 31 Issue 2 Pages 81-87
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe results of 31 Patients with acute subdural hematoma who underwent decompressive hemicraniectomy was reportd. Six selected patients were treated postoperatively with barbiturates. 32% of the patients had a favorable outcome (good recovery and/or moderate disability). 13% had an unfevorable outcome (severe disability and/or vegetative state) and there was a mortality rate of 55%. Careful evaluation of the results revealed that 80% of the patients with GCS scores of 6 to 8 before operation had a favorable outcome. 81% of the mortalities occurred in the patients with GCS scores of 3 to 5. The preoperative ICP was higher than 40 mmHg in all patients and the postoperative ICP was controlled at or below 50 mmHg except in patients who developed diffuse brain swelling. 36 % of the patients with sustained high ICPs of 50 mmHg after the operation had favorable outcomes. Postoperative administration of a barbiturate was effective in lowering the ICP by 10 to 15 mmHg without complications.View full abstractDownload PDF (900K) -
IV : Fluorescein Angiography and Electron Microscopy During Spontaneous Healing ProcessHISAHARU YOSHIOKA, YASUHIRO KATSUME, HIDEKI AKUNE, HIROSHI NAGASAKI1984 Volume 31 Issue 2 Pages 89-99
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSSpontaneous healing processes of experimental central serous chorioretinopathy induced by repeated intravenous adrenalin injections were studied in detail by fluorescein angiography and electron microscopy. The abnormal fluorescein spot in this experimental model changed from the initial ink blot type into the residual type and, further, into the window defect type, before finally disappearing. These findings indicate that the healing process in our model closely resembles those in human. Further, the histological findings suggest that the spot of either residual type or window defect type identified by fluorescein angiography is due to marked enlargement of basal infoldings of pigment epithelial calls and separation of the intercellular gap junction between the pigment epithelial cells; furthermore, the difference between the two types of fluorescein spots depends on the difference in. the degree of such morphological changes, mentioned above.View full abstractDownload PDF (11973K) -
KEN YAEGAKI, NORIAKI KANEKO, RYOHEI OGURA, TADAMITSU KAMEYAMA, CHOKUDO ...1984 Volume 31 Issue 2 Pages 101-105
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA simple procedure for isolation of lysosomes from rat salivary gland was developed. The highest activity for succinate dehydrogenase was found in the 4, 000×g pellet (F-2), the highest activity for acid phosphatase in the 20, 000×g pellet (F-3), and the highest activity for acid DNase in both the 20, 000×g pellet (F-3) and the 4, 000×g pellet (F-2). Acid DNase was extracted from the 20, 000×g pellet (F-3) by treatment with Triton X-100. There were no differences in the proportions or migration patterns in acid DNase for the 20, 000×g pellet (F-3) and the 20, 000×g supernatant (F-4) as observed on pH 4.3 electrophoresed gels. On the pH 8.8 gel, acid DNase from the 20, 000×g supernatant (F-4) yielded a distinct single band; however this band was absent from the 20, 000×g pellet (F-3).View full abstractDownload PDF (530K) -
Clinical and Pathological Differences in Intracerebral Infiltration between Primary Intracranial Lymphoma and Systemic Malignant LymphomaKUNITADA HARA, EIICHIRO HONDA, SEIKICHI KOBAYASHI, NOBUAKI NISHIO, KAT ...1984 Volume 31 Issue 2 Pages 107-113
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIntracranial malignant lymphoma accounts for 0.6 to 3.2%of the total cases of cerebral tumors, and the number of cases reported has increased in recent years. The authors experienced simultaneously two cases; one a cerebral primary malignant lymphoma found in the cerebral basal ganglion and the other probably a result of an intracerebral infiltration of the general malignant lymphoma. The patients were males, aged 33 and 43 years when initially attacked by the diseases. Their initial symptoms and clinical progress closely resembled each other and surgical observations were also similar. In neuro-radiological terms, only a difference in vascularity was observed in the cerebral angiogram but was not observed in the CT scan. With regard to the question of whether it is possible that the discrimination can be achieved clearly in each lymphoma, we have discussed the clinical and pathological differences between the two patients with other reports.View full abstractDownload PDF (9449K) -
EIICHIRO HONDA, TAKASHI HAYASHI, SHINKEN KURAMOTO1984 Volume 31 Issue 2 Pages 115-124
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe incidence of brain tumor in the newborn is extremely low. Choroid plexus papilloma of neuroectodermal origin has been reported in only nine cases, including the present case. Early diagnosis of brain tumor in the newborn is difficult. In addition, there are many difficult factors in the operative treatment of choroid plexus papilloma because of its tendency to hemorrhage and malignancy. Interestingly, a neuroepithelial cyst developed in the posterior fossa following the first operation. We report the present case as an extremely interesting one since the development of neuroepithelial cyst and choroid plexus papilloma appeared to have a common origin on the basis of histological findings, as well as other clinical observations.View full abstractDownload PDF (9044K) -
HITOSHI MOTOORI, SHOTARO SAKISAKA, HIROMU UEDA, KAZUAKI YAMAUCHI, HIRO ...1984 Volume 31 Issue 2 Pages 125-134
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe distribution of microtubules in cultured hepatocytes from rats was observed by indirect immunofluorescence microscopy using rabbit antiserum directed against pig brain tubulin. In hepatocytes cultured at a concentration of 105cells/0.2 ml/cm2, individual microtubules were not well observed due to the formation of an intercellular adhesion and the inability of the cells to spread. Therefore, an attempt was made to culture the cells at a concentration of 104cells/0.2 ml/cm2. Hepatocytes cultured for 48 hours at this concentration spread fully and individual microtubules were clearly observed within the cell. Microtubules were distributed in a reticular pattern around the nucleus and extended in a fibrous pattern in the direction of spreading in the cell periphery. Moreover, a star-like fluorescence from which microtubles appeared to radiate was detected in the perinuclear area. This structure appears to be a microtubule-organizing center. When hepatocytes cultured for 48 hours were treated with colchicine (10-4M) or cold temperature (4°C) for 3 hours, microtubules were less visible and the fluorescence became weak and diffuse. Particularly in the periphery of the spreading cytoplasm, the fluorescence was not seen. In addition, when hepatocytes were cultured in the presence of colchicine from the beginning of cultivation, the attachment and spreading were inhibited. However, attached hepatocytes cultured in colchicine medium for 24 or 48 hours were able to spread in spite of the loss of microtubules. Therefore, it seems that hepatocyte spreding does not depend on microtubules.View full abstractDownload PDF (6879K) -
A Preliminary ReportYASUSHI MIZUKI, MICHIO YAMADA, ICHIRO KATO, YOSHIKO TAKADA, SHUSAKU TS ...1984 Volume 31 Issue 2 Pages 135-143
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThree female patients with dementia were given aniracetam 500 mg, 1000 mg, and placebo for 4-week periods in a double-blind, cross-over study. EEGs and psychometric tests were performed before and during the treatment. From the power percentage of EEGs, aniracetam 500 mg produced an increase of α and fast wave activities but a decrease of slow wave activity. With aniracetam 1000 mg, neither an increase of α activity nor a decrease of slow wave activity were observed. In the psychometric tests, only the patient with a mild dementia responded favorably, according to performance on the tests. However, the scores with aniracetam 500 mg were higher than those with aniracetam 1000 mg. These results indicate that aniracetam may only be effective when dementia is mild and when the dose is carefully titrated.View full abstractDownload PDF (2713K) -
An Important Problem in Postoperative CareHIROYOSHI MIZOTE, KOHTA YATSUKA, YOSHIHIRO NAGASATO, TERUO KAKEGAWA1984 Volume 31 Issue 2 Pages 145-149
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDuring a period from 1976 to 1982, we performed gastrointestinal operation on 2406 cases. Among the 2406 operated cases, 135 (5.3%) developed severe infections. There were 36 (26.7 %) cases which fell into the sequential system failure subsequent to these severe postoperative infection. The mortality rate was high at 51.9%. The organ failure began to appear by the second week after the development of infections in the lung, liver, and kidney. When the system failure involved four organs or more, all the patients died. The correlation of the basic cause for the multiple organ failure should not be neglected.View full abstractDownload PDF (517K) -
HIROYOSHI MIZOTE, TERUO KAKEGAWA, YOSHIHISA TANAKA, KOHTA YATSUKA, KAZ ...1984 Volume 31 Issue 2 Pages 151-155
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA rare case of eosinophilic granuloma with an ulcer in the antrum portion of the stomach belonging to the localized type due to some parasite was reported. In spite of numerous examinations before the operation, a confirmed diagnosis was not obtained.View full abstractDownload PDF (2803K) -
MASANAGA YOSHIMOTO1984 Volume 31 Issue 2 Pages 157-165
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe examined 20 episodes of nephrotic crisis (Cx) in 13 nephrotic children and report hematological findings and pathogenesis of the crisis. All physical and clinical data including serum and plasma protein levels and urinalysis, were recorded at the onset of Cx, during recovery and the interventing interval. There was a total of 20 incidences of Cx: 17 occurred at relapses and 3 at the onset of the nephrotic syndrome. We compare the Cx data with the data we additionally collected from 14 other children sufferring with nephrotic syndrome but without the complication of Cx (non-Cx) either at relapses (10) or first onset (4). The most characteristic Cx clinical manifestations (compared with non-Cx group) were abdominal pain in 85 % (cf. 14.3 %), vomiting in 70 % (cf. 0 %), and facial pallor in 65% (cf. 7.1 %). There were significant differences of the Cx clinical and hematological data when compared with the non-Cx data. The Cx group showed a significantly lower blood pressure, higher hematocrit value, lower serum sodium concentration, lower C3 level, lower CH50 activity and lower serum total protein and albumin (standardized for hematocrit values). We conclude that hypovolemia was the pathogenesis for Cx: the sudden loss of massive serum protein into urine, causing subsequent hypoproteinemia (hypoalbuminemia) and decreased colloidal osmotic pressure impairing re-entry transport of interstitial fluids from tissue to the blood. The hypovolemia of Cx is aggravated by the hyponatremia which arises due to a sodium shift from the blood to interstitial tissue. We investigated the role and mechanism of a possible hypoadrenocortical state and report negative findings in all cases.View full abstractDownload PDF (834K) -
KASEI KOJIMA, ARATA SUGITA, HISAHARU YOSHIOKA1984 Volume 31 Issue 2 Pages 167-170
Published: December 20, 1984
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (5753K)
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