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Volume 45, Issue 2
Displaying 1-13 of 13 articles from this issue
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Methodology and Clinical UtilityHIDEAKI OGATA1998 Volume 45 Issue 2 Pages 165-170
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn this study, we explored the methodology and clinical utility of reticulated platelets analysis. Reticulated platelets were measured using flow cytometry in peripheral circulation with thiazole orange (TO). We chose fixed platelet-rich plasma as the sample since it has been known to give stable results. The percentage of reticulated platelets in 7 patients with idiopathic thrombocytopenic purpura (ITP) was significantly increased (8.41±5.35%; mean±SD), compared with that in 21 normal subjects (1.92±1.27%). The value in 16 patients with liver cirrhosis was slightly below normal (1.86 ± 0.85%). These findings suggested that thrombopoiesis was not promoted under the condition of hypersplenism or of abnormal pooling, and that any elevation in the percentage level of reticulated platelets could be clinically useful in the diagnosis of ITP.View full abstractDownload PDF (2286K) -
HIROSHI SUZUKI, MICHIO SATA, MASARU SASAKI, SHIROU MURASHIMA, FUYUHIKO ...1998 Volume 45 Issue 2 Pages 171-174
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe mutation of glucocorticoid responsive element (GRE) of HBV DNA obtained from a patient with chronic hepatitis B was evaluated. This patient showed fatal course by glucocorticoid administration. The HBV DNA from this patient (GRE-M) and two patients with HBeAg positive chronic hepatitis B (GRE-W1, 2), whose HBV DNA have few mutations, were examined. The 212 bp region from nt.274 to nt.485 (GRE region) was amplified by PCR and the nucleotide sequence was determined. A base mismatched sequence of the latter half of the GRE consensus sequence was confirmed at nt.296-301 (G1), nt.347-352 (G2), nt.359-364 (G3), and nt.473-478 (G4). Also one base mismatched sequence of the AP-1 response element was detected at nt.331-337 (A1). The nucleotide substitutions in GRE-M generate three putative loop formation sites, four bases in length, from nt.22 to nt.31 (L1), nt.35 to nt.42 (L2), and nt.74 to nt.83 (L3). The L1 was located just upstream of the G1. The L2 was located between the Al and the G2. These mutations follwed by three dimentional form change may affect the responses to glucocorticoid.View full abstractDownload PDF (634K) -
SATOE SHIGEMATSU1998 Volume 45 Issue 2 Pages 175-179
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe therapeutic role of interleukin (IL)-1 receptor antagonist, a potent inhibitor of IL-1, was investigated using peripheral blood mononuclear cells from patients with ulcerative colitis and Crohn's disease. Administration of IL-1 receptor antagonist inhibited IL-1β-augmented IL-1α and tumor necrosis factor-α production by mononuclear cells. Prednisolone caused a decrease in IL-1 receptor antagonist release, whereas sulfasalazine had no modulatory effect. Interestingly, lgG caused an increase in IL-1 receptor antagonist release. In conclusion, IL-1 receptor antagonist and related molecules may have therapeutic value.View full abstractDownload PDF (853K) -
TERUFUMI SAKAI1998 Volume 45 Issue 2 Pages 181-185
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIt is unclear whether patients with chronic liver disease have impaired pancreatic exocrine function. This study was designed to answer this question. Pancreatic exocrine function was evaluated with pancreatic function diagnostic (PFD) test in 16 patients with chronic hepatitis, 32 patients with liver cirrhosis, and 26 patients with cirrhosis and hepatocellular carcinoma (HOC) and in 26 control subjects. The values of PFD test were significantly lower in both patients with liver cirrhosis (70.5±10.7%, P<0.01) and patients with cirrhosis and HOC (68.5±11.2%, P<0.01) than in controls (77.8±6.5%). Although the value was also lower in patients with chronic hepatitis (71.8±11.4%) than in that in controls, the difference did not reach the level of significance. To evaluate potential effect of the impairment of para-amino-benzoic acid (PABA) absorption on the results of PFD test, we further performed a PABA absorption test in 16 patients with chronic liver disease who had abnormal PFD tests. There were no significant differences of the values of PABA test between control group and any patients groups. These results suggest that patients with chronic liver disease have an abnormal pancreatic exocrine function.View full abstractDownload PDF (1390K) -
HITOSHI FUKUDA1998 Volume 45 Issue 2 Pages 187-193
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSPercutaneous ethanol injection therapy (PEIT) is now widely used for small hepatocellular carcinoma (HCC). However, only limited information is available regarding predictors of long-term prognosis of patients with small HCC after PEIT. The relationship of pretreatment clinicopathologic and biologic factors (age, sex, virus marker, Child-Pugh classification, tumor size, number of tumor, histologic grade, tumor staining, α-fetoprotein level, AFP-L3%, and Ki67 labelling index) to long-term prognosis in 41 patients with HCC were studied. Over-all survival rates of patients were 73.5% in 3-year, 34.7% in 5-year, and 27.0% in 7-year. Of the 12 variables investigated, Child-Pugh classification (p=0.0243), histologic grade (p=0.0098), tumor staining (p=0.0012), AFP-L3% (0.0093), and Ki67 labelling index (p=0.0467) were significantly associated with the long-term prognosis by univariate analysis. According to the multivariate analysis using Cox's proportional hazard model with step-wise method, tumor staining (p=0.0024) and AFP-L3% (p=0.0137) were significantly associated with the long-term prognosis after PEIT. In conclusion, the study found that positive tumor staining of HCC and positive AFP-L3% in serum were the predictor of poor prognosis in patients with HCC after PEIT.View full abstractDownload PDF (1244K) -
Immunocytochemical Localization of Aquaporin-2HIROKO MAESHIRO1998 Volume 45 Issue 2 Pages 195-202
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSLittle is known about the effect of prematurity on water reabsorption in the renal tubules by anti-diuretic hormone (vasopression: ADH). The purpose of this study was to assess the different mechanisms of maintaining water balance in newborn and in adult rats on ADH and aquaporin-2 (AQP2) axis. After the dehydration, the plasma ADH in newborn and adult rose 104.6% and 117.2%, respectively. In immunocytochemical study, AQP2 stained more intensively in dehydrated rats. The dehydrated adult rats apical membrane in the IMCD cells showed more intensive staining than in the control rats. Adult rats revealed more intensive staining than newborn after the dehydration in the IMCD cells. We conclude that low ADH secretion in response to dehydration might lead to inadequate production of AQP2 resulting in an increased tendency in newborn to become dehydrated.View full abstractDownload PDF (6294K) -
Laparoscopic Versus Open Technique for Familial Adenomatous Polyposis and Ulcerative ColitisYASUMI ARAKI, HIROHARU ISOMOTO, YOSHIAKI TSUZI, ATSUSHI MATSUMOTO, MAS ...1998 Volume 45 Issue 2 Pages 203-207
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSClinical aspects of laparoscopy combined total colectomy (LTC)(n=10) and open total colectomy (OTC)(n=29) with ileorectal anastomosis for familial adenomatous polyposis and ulcerative colitis are compared in a retrospective study. The mean operative time was 282 (range, 169 to 420) minutes in the LTC group and 274 (range, 139 to 570) minutes in the OTC group. The mean volume of operative blood loss was 321 (range, 52 to 728) ml and 471 (range, 48 to 1040) ml for the LTC and OTC groups, respectively. Nasogastoric tube could be removed after POD 1.2 vs. 5.8 (p<0.05), the mean time to passage of stool was 1.9 (range, 1 to 3) vs. 5.2 (range, 3 to 7) days (p<0.01), and in the LTC group watery stool was soon made solidification after POD 23.4 vs. 84.1 (p<0.01). Laparoscopy combined total colectomy may prove to have one-stage restorative total colectomy without a temporary ileostomy due to early solidification of watery stool and more benefits than conventional open surgery.View full abstractDownload PDF (2849K) -
YASUMI ARAKI, HIROHARU ISOMOTO, YOSHIAKI TSUZI, ATSUSHI MATSUMOTO, MAS ...1998 Volume 45 Issue 2 Pages 209-213
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSImprovement of functional outcome after proctocolectomy for ulcerative colitis and familial adenomatous polyposis was compared between transanal ileal pouch-anal anastomosis (TIAA group, n=29) and double-stapled ileal pouch-anal anastomosis (DS-IAA group, n=8) . Clinical functions were evaluated using a functional scoring system, and physiologic functions by anorectal manometry after one year postoperatively. Although in the T-IAA group 4 of the 29 patients (13.8%)displayed partial incontinence (<9 points), all of 8 patients in the DS-IAA group showed good results referring to continence (>10 points). The maximum resting pressure was 44.3±5.2 cmH2O in the T-IAA group vs. 56.6±5.8 cmH2O in the DS-IAA group, and postoperatively the maximum squeezing pressure was 96.8±9.2 cmH2O in the T-IAA group vs. 106.3±8.1 cmH2O in the DS-IAA group. There was a significant difference of maximum resting pressure and no significant difference of maximum squeezing pressure between the two groups. The length of the high pressure zone in the anal canal was significantly shorter in patients of the T-IAA group (2.1±0.8 cm) than in those of the DS-IAA group (3.5±1.1 cm) (p<0.05). The DS-IAA is associated with excellent objective physiologic and subjective functional results. This reflects the sacrifice of the internal anal sphincter 1.5 cm cephalad necessary to effect this anastomosis at a mean of 1.4 cm from the dentate line.View full abstractDownload PDF (2818K) -
TOSHIHIRO MATSUO, AKIHIRO HAYASHI, SHINZO TAKAMORI, KOHSUKE TAYAMA, KO ...1998 Volume 45 Issue 2 Pages 215-217
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe describe a case of intralober pulmonary sequestration in association with tuberculosis. Sequestrations of the lung are classically divided into two types of extralober and intralober. Intralober pulmonary sequestration in association with tuberculosis is rare. We diagnosed the present case to be Pryce type 1 with tuberculosis infection.View full abstractDownload PDF (5569K) -
NAOFUMI ERIGUCHI, SHIGEAKI AOYAGI, MASAO HARA, MOTONORI SAKU, KOJI YOS ...1998 Volume 45 Issue 2 Pages 219-222
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSLeiomyosarcoma of the small bowel mesenterium is a rare entity. Approximately 21 cases originating from the small bowel mesenterium have been described in the Japanese literature. Differentiation from its benign counterpart, leiomyoma, and other connective tissue tumors is often difficult, but it is important because each respective tumor type has an entirely different prognosis. The case of a 65 year-old-man in whom an 9×6×5 cm leiomyosarcoma of the mesenterium was excised surgically is presented.View full abstractDownload PDF (6058K) -
A Case ReportMAMORU ARIYOSHI, KENSEI NAGATA, MANABU KUBO, KYOSUKE SONODA, YASUTO YA ...1998 Volume 45 Issue 2 Pages 223-225
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSStress fractures of the tarsal navicular bone are rare injury and assessing its healing is difficult. Tenderness over the tarsal navicular on physical examination is the most reliable sign for assessing fracture healing. However, it is desirable to assess fracture healing with some imaging method. We used serial magnetic resonance imaging (MRI) to assess healing in a patient with a tarsal navicular stress fracture. MRI was useful for the assessment of fracture healing of tarsal navicular stress fracture in our case.View full abstractDownload PDF (4519K) -
A Case ReportNAOFUMI ERIGUCHI, SHIGEAKI AOYAGI, MASAO HARA, TAKASHI MIYAZAKI, MASAT ...1998 Volume 45 Issue 2 Pages 227-230
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThis report describes a 49-year-old woman with recurrent massive gastrointestinal bleeding from jejunal varices without portal hypertension. Preoperative diagnosis was obtained by abdominal computed tomography, superior mesenteric arterial angiography and percutaneous transhepatic portography. Percutaneous transhepatic portographic findings revealed no step-up of oxygen concentration and normal pressure in the portal vein, only dilation of superior mesenteric vein. Jejunal resection and anastomosis resulted in complete resolution of the bleeding, and the patient has experienced no recurrent bleeding over a 4 year follow-up period. A review of the literature shows that this syndrome is nearly always characterized by portal hypertension, generally due to liver cirrhosis. Accurate preoperative diagnosis is often difficult. We report a very rare case of jejunal varices without portal hypertension.View full abstractDownload PDF (7532K) -
A Report of Three Cases and a Review of Published ReportsNAOFUMI ERIGUCHI, SHIGEAKI AOYAGI, MASAO HARA, TAKASHI MIYAZAKI, EIJI ...1998 Volume 45 Issue 2 Pages 231-234
Published: June 15, 1998
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSPseudomyxoma peritonei is a disease characterized by the progressive accumulation of mucinous ascites within the abdomen and pelvis. Metastatic disease outside the peritoneal cavity is unusual. Gastrointestinal function is lost from external compression of stomach, small bowel, and large bowel. We present three cases of pseudomyxoma peritonei which were treated by different therapeutic methods. Case 1 was a 61-year-old man who underwent treatment by appendectomy with administration of Cisplatin and Doxorubicin hydrochloride into the intraperitoneal cavity. Case 2 was a 64-year-old woman who underwent bilateral oophorectomy with administration of Cisplatin and ADM into the intraperitoneal cavity. About 4 years after the first operation, she died of peritonitis due to small and large bowel' perforations underlying recurrent tumors. Case 3 was a 79-year-old woman who underwent surgery to evacuate about 4000 ml of mucinous ascites, and received intraperitoneal administration of 5-Fluorouracil (500 mg/day) for 5 days without severe complications.View full abstractDownload PDF (3185K)
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