In order to clarify the mechanism of neuroleptanalgesia (NLA) in the central nervous system, an experiment was performed using droperidol and fentanyl citrate. The subjects of the experiment were rabbits.
1) It wa s found that the average evoked potentials in the cerebral cortex through ATAC due to stimuli on the sciatic nerve were composed of three small negative responses (N
1, N
2, N
3), followed by a positive response (P) and four negative responses (N
4, Ne
5, Ne
6, N
7).
2) With regard to the average evoked potentials in the cerebral cortex, the late co mponents (N
4, N
5, N
6, N
7) exhibited stronger inhibitory effect than the early components (N
1, N
2, N
3) by droperidol.
3) As for fentanyl citrate: components N
1 and N
2 exhibited strong inhibitory effect, while components N
3, N
6 and N
7 exhibited weak inhibitory effect. When administered a proper dose, components P, N
4 and N
5 exhibited facilitatory effect.
4) When droperidol and fentanyl citrate were admin istered in combination at a ratio of 50: 1, for components N
1, N
2, P. N
4 and N
5, the functioning observed was identical to that observed when only fentanyl citrate was administered. However, the inhibitory effect became stronger for component N
3, and for components N
6 and N
7, the increased functioning during the proper dose was observed to become stronger.
5) Through stimulation of the sciatic nerve, three small negative responses (HN
1, HN
2, HN
3) were observed in the hippocampus, followed by three negative responses (HN
4, HN
5, HN
6).
6) With regard to the average evoked potentials in the hippocampus, both components HN
5and HN
6 exhibited stronger inhibitory effect than components HN
1, HN
2, HN
3 and HN
4.
7) As for fentanyl citrate: the early components HN
1, and HN
2, in addition to component HN6, exhibited strong inhibitory effect; while components HN
3, HN
4 and HN
5 exhib ited weak inhibitory effect.
8) When droperidol and fentanyl citrate were administered simultaneously, for components HN
1, HN
2 and HN
6, the functioning observed was identical to that observed w hen only fentanyl citrate was administered. However, for all of the other components especially for both components HN
4 and HN
5, the inhibitory effect was observed to become stronger. From the experimental results listed above, it has become clear that within the effects of NLA regarding the central nervous system, the analgesic action, in addition to functioning in the sensory afferent pathway, fulfills a substantial role functioning in the higher center in the hippocampus.
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