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Volume 18, Issue 3
Displaying 1-7 of 7 articles from this issue
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K. NODA1971 Volume 18 Issue 3 Pages 117-126
Published: July 30, 1971
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn isolated skeletal amphibian muscles, significance of the transient increase in 45Ca dissociation occurring by ouabain application was investigated in connection with a detailed explanation of the mechanism of inhibiting effect of ouabain on active sodium efflux. Washout experiments of 22Na and 45Ca ions were made for determining the kinetic behaviors of these ions. 1. By changing experimental conditions, the locations of Ca or Ca++ in the muscle fibre could be divided into surface component, membrane protein, hydrophilic membrane lipid, tubular surface, and intracellular storage. 2. A previous report by the present author disclosed that the nature of ouabain action was not decalcification from the membrane. An increase in 45Ca dissociation inevitably observable following ouabain treatment was presumably brought about through a transient increase in simple diffusion of 45Ca ions released from protein anionic sites of the membrane. The increase had no relation to pump activity nor to alteration in cellular Ca++, and it was closely relating to an application of ouabain. 3. An increase in 45Ca release occurring simultaneously with a reduction in ouabain-sensitive, Ca-independent 22Na efflux may be explained in terms that covalent binding of unsaturated lactone rings of ouabain to protein portion renders Ca ions on the sites of membrane protein releaseable indirectly by altering the conformation of protein including transport enzymes. The portions of protein which are available for this type of binding may not be original Ca sites. 4. Substitution experiments of divalent ions indicated that either membrane structure or enzymatic properties in the membrane, which are maintained with help of Ca ions, not with other divalent ions, may be a prerequisite for expressing ouabain action. When Ca ions in the resting membrane are biophysically considered some properties other than charge number should be taken into account.View full abstractDownload PDF (1211K) -
KAZUKO AKIYAMA, FIJI KIMOTO1971 Volume 18 Issue 3 Pages 127-135
Published: July 30, 1971
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSMucosal glycoprotein, possessing a fucomucan-type carbohydrate composition, was isolated from swine stomach lining powder. It was found to possess the organ specificity as well as the species specificity, in addition to the blood-group activity. Such an antigenicity was not influenced by the treatment with various glycosidases (blood-group destroying enzymes). The alkaline borohydride treatment of the glycoprotein resulted a partial loss of the antigenicity when only the serine-carbo-hydrate linkages were cleavaged, but a complete loss when the threonine-carbo-hydrate linkages were cleavaged. On the basis of these experiments, the antigenic determinant was assumed to reside in the core protein including the carbohydrate linkage (threonine-galactosamine linkage) within the glycoprotein molecule.View full abstractDownload PDF (4737K) -
I. ANTIGENICITY OF SIALOPROTEIN MOIETYTAKAYO KURANARI, EIJI KIMOTO, MITSUWO HARA1971 Volume 18 Issue 3 Pages 137-146
Published: July 30, 1971
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSAntisera, obtained by immunization of rabbits with proteinpolysaccharide complex of human costal cartilage, produced at least two zones of precipitate with antigen on the Ouchterlony assay. The major proteinpolysac-charide fraction, obtained from a DEAE cellulose column chromatography and from a gel filtration, produced a single precipitate line which fused with that of bovine material and therefore was nonspecific between human and bovine material. On the electrophoresis in an agarose gel as well as in a Pevikon powder block, a discrepancy in a mobility occurred between the major glycosaminoglucuronoglycan-containing spot and the antigenic moiety. This antigenic material possessed the chemical composition characteristic to the glycosaminoglucuronoglycan-core protein complex as well as the sialoprotein. After hyaluronidase digestion, this antigenic fragment was characterized rather as a sialoprotein.View full abstractDownload PDF (6501K) -
SHINKEN KURAMOTO, MITSUO WATANABE1971 Volume 18 Issue 3 Pages 147-152
Published: July 30, 1971
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn 3 cases of idiopathic intention tremor stereotaxic thalamotomy was conducted on the posterior portion of the VL nucleus and the anterior portion of the V. im. e., of the thalamus, and the subthalamic area abutting on these portions, which resulted in abolishment of intention tremor for 8 to 16 months after operation in all the 3 cases treated.View full abstractDownload PDF (3931K) -
FUMIO YAMASHITA, TAKAKO FUNATSU, KIYOTAKA NAGAYAMA, HIDEAKI ARIHIRO, S ...1971 Volume 18 Issue 3 Pages 153-160
Published: July 30, 1971
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe therapeutic effect and the side effect of prednisolone in two regimen, “alternate-day (every 48 hours)” versus “daily” (continuous, divided in 3-4 doses) were evaluated in 10 children with nephrotic syndrome (late responder and non responder case) using cross-over method. The side effects, especially hypertensive tendency, and the weight gain were less, however, therapeutic effect was weak in the former regimen compared to the latter. No significant differences were noted in the adrenocortical response to synthesized ACTH between two steroid regimen.View full abstractDownload PDF (3401K) -
KAZUTOYO INANAGA, MASACHIKA OSHIMA, HISAYUKI TACHIBANA, KENICHI NAKAMU ...1971 Volume 18 Issue 3 Pages 161-168
Published: July 30, 1971
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn three cases of schizophrenia, ill for three-six years with no sign of remission under various psychopharmacotherapies, L-Dopa was used with the major tranquilizers which had previously been used. Subsequently, remarkable recovery was noted. The tentative dosage of L-Dopa in this research was 400-1200 mg per day. Hallucination and thought disorder had disappeared as well as apathy and lack of spontaneity. In one case, upon the suspension of L-Dopa, the patient's symptoms exacerbated. Continuous administration of L-Dopa is necessary for the improvement of the symptoms.View full abstractDownload PDF (4396K) -
1971 Volume 18 Issue 3 Pages e1-e4
Published: 1971
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (353K)
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