It seems that hesperidin, that is, Vitamin P, takes part in increasing capillary resistance to some extent, and in decreasing capillary permeability. But Vitamin P and Vitamin C are generally not the only substances which affect capillary hemorrhage or permeability. It is thought that capillary hemorrhage and permeability are affected greatly also by Vitamin K, Vitamin B and the protein properties contained in food, especially by amino acids.
There are various methods for measuring capillary resistance and filtrate, but since these are imperfect, it is almost impossible to conclude without hesitation that various kinds of hemorrhage of the skin are due to one or two factors alone. From a clinical viewpoint, it is often thought that various factors are involved. Although the results of Szent-Györgyi's experiments on animals were totally contradicted, it apparently cannot be denied that there are cases in which some effects can be expected. I realize the necessity of conducting further comprehensive experiments in the future.
The gist of the above research was read before the Third Korea-Manchuria Medical Meeting held in Hsinking on September 3, 1938.
Recently I have received a large amount of hesperidin manufactured by the Takeda Company, and am about to conduct experiments with it.
In conclusion, I wish ot express my deep gratitude to Dr. Morinaka, the director of the Dairen Hospital, for his interest and encouragement, to Dr. Makino for his guidance, and to Mr. Goro Yano for his help in my research.
The work was undertaken with the aid of the scholarship from the research fundation of South Manchuria Railway Company. (Katashi Makino).
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