The writer examined the pressure, specific gravity, pH., quantity of sugar and protain, the number of blood celles, leper bacilli, colloidal reaction and immune reaction of the cerebrospinal fluid in 31 leprous cases (lepra nodosa 20, lepra ner- vorum 11). The immune reaction was compared with that of the serum in the same patients. The following results were obtained.
(1) The pressure was 55-140mm. in a side position and 210-390 in sitting position, the specific gravity 1006-1010, pH 7, 6-8, 6. The above mentioned results were the same as those in normal conditions of healthy bodies, and there was no marked difference between lepra nodosa and nervorum.
(2) The quantity of sugar usually increased in all leper patients. The increase was more or less in correspondence with the seriousness of the disease. The content of sugar in leprous spinal fluid was 0, 089g/dl-0, 2g/dl in average 0, 122g/dl.
(3) The protain of leperous spinal fluids was more or less influenced by the condition and state of the disease of lepra nodosa and no increase was noticed in lepra nervorum.
(4) The number of blood cells in spinal fluids increased a little in serious cases of lepra nodosa. Leper bacilli could not be found even in one of 31 cases.
(5) The globrin reaction appeared positive in 48% and these were all serious lepra nodosa or nervorum with the complication of syphilis.
(6) Goldsole. reaction appeared in 16 cases positive (57%). Patients who had positive reaction of syphilis, globrin and leper were also found positive in the gold- sole reaction. An intensive positiveness of the goldsole reaction could not be found especially in lepers.
(7) In two cases of lepra nervorum in which the Murata's reaction with the spinal fluid was positive, there appeared negative reaction with the serum. The S. G. R. was positive and the W. R. positive in 19% with the spinal fluid. While syphilitic reactions were found positive with the spinal fluid, they were almost negative with the serum.
(8) An alcoholic extract of leprous nodules could also be used as an antigen in carrying out syphilitic and leprous reaction with the spinal fluid, the precipita- tion reaction positive in 19% and the binding reaction positive in 52%. A liquid emulsion of leprous nodules or tubercle bacilli was suitable as a pure antigen for leprous reactions with the spinal fluid. (32% positive in complement binding reac- tion). The positive cases of leprous reactions with the spinal fluid were also posi- tive with the serum.
(9) All positive reactions with leprous spinal fluids were generally weaker than those with the serum and positive cases of the spinal fluid were very fewer than those of the serum. We could not assume that antibodies could pass from the serum into the spinal fluid under an ordinary condition.
(10) It was very interesting to notice that in leprous reactions of the spinal fluid or serum an antigen from cultured nodules was more effective than that from excised leprous nodules. From cultured nodules numerous lever bacilli could be cultured successfully.

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The writer reported an interesting case of leper. In that case 6 of 7 brothers who came from the parents by a marriage of cousins, suffered from leper. The souce of the disease seemed to be the paternal uncle who had lived with the family. 3 of them were deaf and dumb inherently and 4 had a remaining mem- brane in the pupils. According to previous papers 2 brothers or more, who suffered from leper, were infected almost always from the mother.
The infection of leper seemed to have nothing to do with the consanguineous marriage. The congenital deaf and dumbness in this case owed to the consan- guineous marriage of the parents, remaining membranes of the pupils, however, seemed not due to the latter.

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[in Japanese]

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