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Volume 24 (1955)
- Issue 6 Pages 353-
- Issue 5 Pages 277-
- Issue 4 Pages 204-
- Issue 3 Pages 133-
- Issue 2 Pages 64-
- Issue 1 Pages 1-
Volume 24, Issue 5
Displaying 1-8 of 8 articles from this issue
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Kiyoshi Harada1955 Volume 24 Issue 5 Pages 277-282
Published: September 20, 1955
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSThe routine staining, Masson's Methylgreen-Pyronin, PAS methods Lipsid staining (Sudan III, Sudnn Black, lipophanerosis) Nileblue sulfate, were applied to investigate the formation of lepra cells. The results revealed that lepra cells derive from fixed macrophages and monocytes. The phagocytosed bacilli and the cytoplasma underwent fatty degenerotion and neutral fat was discharged into blood.
These changes can be adequately divided into three stadia by the histochemical methods for fatty substances, 1) the leprosy bacilli are phagocytosed by histiocytes, 2) fatty degeneration is taking place and 3) neutral fat is produced and vacuoles are observed.View full abstractDownload PDF (749K) -
Shinji Nishimura, Taro Masuda, Isao Hayashi, Ryuzo Sonoda1955 Volume 24 Issue 5 Pages 283-287
Published: September 20, 1955
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSSeven groups of each 20 rats with large lepromata were provided. Groups I, II and III were administered INAH (Hycozid: Takeda) 0.4mg/kg, 4mg/kg, and 40mg/kg, and groups IV, V end VI DDS (Yoshitomi) 1.5mg/kg, 15mg/kg and 150mg/kg, resepectively, six days in a week, per os for 150 days. Group VII was remained untreated as the control.
The size and nature of lepromata was examined at the interval of 30 days, autopsied and the weight of lepromata and bacillus distribution were examined (Tables 1, 2 and 3).
1) In severe murine leprosy 0.4mg/kg of INAH was ineffective for 150 days, but the increased doses of 4.0mg/kg or 40mg/kg was effective. In 4 of 10 cases treated with 40mg/kg INAH for the longest period the lepromatous granulation disappeared, but the bacilli were observed in the site and lymph nodes.
2) DDS was ineffective when administered 1.5mg/kg, 15mg/kg and 150mg/kg, daily.
From these results, the chemical agents appeared most effective when administered by the largest dose as possible.View full abstractDownload PDF (574K) -
The Influence of Murine Leprous Infection on Tuberculosis in MiceYoiehiro Kawaguchi1955 Volume 24 Issue 5 Pages 288-294
Published: September 20, 1955
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSThe slightly increased resistance in the mice infected with murine leprosy bacilli against tuberculous infection was verified by the following results.
It appears that the mice inoculated with murine leprosy bacilli showed partial immunity of lower grade against infection with virulent tubercle bacilli. Because it was shown that the growth of tubercle bacilli in organs was inhibited in the early stage of the infection, though there was no difference between the survival time of treated mice and that of the controls.
When the mice severely infected after intraperitoneal inoculation with murine leprosy bacilli were infected with tubercle bacilli, the latter were slightly more abundant than those of the controls, in culture made from the organs.View full abstractDownload PDF (802K) -
YOSHIMI HARADA, SHIGETAKA TAKASHIMA1955 Volume 24 Issue 5 Pages 295-320_3
Published: September 20, 1955
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSIn this treatise the authors described the result of the histopathologic investigation concerning three cases of lepromatous leprosy.
I Case, a 18 years-old boy, died of acute peritonitis from the gangrenous appendicitis. II Case, a 171/4 years-old boy, had been suffering from leprosy since about 2 years and III Case, a 48 years-old man, had been suffering from leprosy and died of suppurative meningitis. It was probable that the meningitis would caused by leprous lesions. Autopsy showed that the brain and cord were affected similarly and histologically were found the lepra bacilli in the meninge and brain; therefore the findings should be probable pronounced as the leprous meningo-encephalitis. But up to that time this patient has complained during almost thirteen years of the malady.View full abstractDownload PDF (2888K) -
REACTIONS PRODUCED BY THE MITSUDA OR DHARMENDRA ANTIGENKen YANAGISAWA, [in Japanese], [in Japanese], Toshiyasu SAITO, [in Jap ...1955 Volume 24 Issue 5 Pages 322-326
Published: September 20, 1955
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSAs a prelude for the study on standardization of the lepromin reaction the authors made a comparative observation of the skin reactions produced by the Mitsuda or Dharmendra antigen in 3137 leprous patients.
Both the early and late reactions were read and a correlation between the Mitsuda and Dharmendra reactions was studied, then it was concluded that so far as the lepromin test is concerned both the antigens are the same in the antigenicity, and the possible antigenic material may be contained solely in leprosy bacilli.View full abstractDownload PDF (280K) -
Teh Second Report. BASIC OBSERVATIONS FOR THE SETTLEMENT OF CRITERIA FOR READING THE REACTIONSKen YANAGISAWA, [in Japanese], [in Japanese], Toshiyasu SAITO, [in Jap ...1955 Volume 24 Issue 5 Pages 327-336
Published: September 20, 1955
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSAn attempt was undertaken by the authors to examine the difference between the early and late reactions, and to determine the criteria for reading the Mistuda and Dharmendra reactions from the skin-reactionological point of view.
Analyzing statistically the distribution frequency of size of reactions, following criteria were suggested.View full abstractDownload PDF (881K) -
Tamiro MOTOJIMA1955 Volume 24 Issue 5 Pages 337-341
Published: September 20, 1955
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESS6 cases of lingua nigra in lepromatous patients were observed since March, 1954. 4 of them were male and the rest female, the age ranging from 24-52.
In every case, the dorsal surface of the tongue was black or dark gray, suggesting of the wet rat skin. The patients tasted astringent, but severe pain was not complained. The upper half area of papillae filiformes was found minutely keratinized. The lesion spread from the anterior part of papillae circumvallatae to the whole dorsal surface of the tongue, and was smaller nearer to the lip and disappeared, leaving intact one or two thirds of the tongue tip area. No pain was complained when this hairy body was pulled by a pincette, but the loss of taste sense was recognized.
Blood, urine and bacterial examinations and syphilitic reactions revealed no distinct findings. Treatments of rinsing with 2% boracic acid, 0.2% acriflavin solution, application of caustic silver and curettage produced favorable effects upon all cases from 1 to 4 weeks.
This lingua nigra appeared after extraction of teeth or after treatment of the teeth duct of the lower jaw.
We will try to carry out clinical experiments and investigate the mechanisms.View full abstractDownload PDF (743K) -
[in Japanese]1955 Volume 24 Issue 5 Pages 342-350
Published: September 20, 1955
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSDownload PDF (2446K)
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