The functions of the autonomic nervous system were tested in 50 cases :-33 cases of lepra nervorum and 17 cases of lepra tuberosa.
The tests were done by the method with drugs, that is, with adrenaline chloride, pilocarpine chlorate and atropine sulphate.
There were 16 cases in the lepra nervorum and 10 cases in the lepra tuberosa which can be though normal.
6 cases of the lepra nervorum, and 3 cases of the lepra tuberasa were observed to be very sensitive for adrenaline. 15 cases of the lepra nervorum and 3 cases of lepra tuberosa to be very sensitive for pilocarpine, and 3 cases of lepra nervorum and 3 cases of lepra tuberosa for atropine.
According to above results, the so-called parasympathetic nervous system was in the sensible condition in 9 cases of leprra nervorum and in 2 cases of lepra tuberosa, and the sympathetic nervous system was in the sensible condition in 11 case of lepra nervorum and 2 cases of lepra tuberosa, while the autonomic nervous system was either in an unstable or in a less sensible condition in 7 cases of lepra nervorum and in 3 cases of lepra tubero
Especially those of notice were the cases of lepra nervorum in which the parasym-pathetic nervous system was observed to be sensible and were more than the others and the cases of lepra tuberosa in which the sympathetic nervous system was observed to be sensible were comparatively more than the other; that is, the nervous sensibility in either type is quite contrary.
Of the relation between the blood type of lepers and the functions of autonomic nervous systems.
I experimented on the blood of 50 lepers, and result is :-
In 26 cases out of 50 lepers whose autonomic nervous system have not abnormal functions were
In 24 cases out of 50 lepers whose autonomic nervous system have abnormal functions were:-
Thus type A in lepers bears a higher rate of increasing than in healthy persons, type B less lowering, type O nearly equal, and type AB notably lowering.

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The author has experienced the good effect in administrating an organic gold compound "Solganal " in twenty cases of acute leprous iridocyclitis for whom atropine or other usual disinflammations had no effect (viz. remakably effective in 50 % of the cases, moderately in 30 % and slightly in 20 %). First of all diminished the acute inflammation. Namely the pains and congestions disappeared after only two or three times of its injection. Next the visual power was also improved. But we could not find any effect for the leprous keratitis and leproma of sclera.
As the previous authors stated, it is p obable that the gold compound does not directly acts upon the leprous bacilli, but it acts as stimulant for treatment of the acute inflammation caused by the bacilli. Hence the author is inclining to support the Heub ner's theory for the process of its effective action which is regarded to be the intoxication of the capillary vessel. Moreover the accessory actions also appear, but they are not dangerous at all. Unconveniently, however, this "Solganal " is too expensive for general use.
" Triphal " takes few effects on leprous affections of eyes though it has been hitherto applied to leprous treatment in Japan. The author is delighted to be able to affirm the Hoff mann's theory from the above experiment of " Solganal."

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It is generally believed that there is a definite bacteriological relation between the quantity of bacilli and the degree of the morbid change caused by them.
The author made an emulsion of twenty times of leproma and vaccinated its 0, 5-1, 0 c.c. In the case of observations on the influence of gynocardic oil and other medicals or nutriments upon the rats morbid change, we noticed that the exessive quantity of the vaccinated bacilli may cause the severe acute morbid change through which the result of a second influence may be put in confusion to he judged. Hence taking the above mentioned emulsion as the original, we diluted it by 10-100-1.000-10.000 times and vaccinated 0, 5 cc of each liquid on four white rats, which we billed after four months and we compared their morbid changes.
As for the result of the experiments, a severe morbid change was produced by the original liquid or the liquid diluted by 10 times, but a slight change by the liquid diluted by 100 times or more. It is very into*resting that even the liquid diluted by 10.000 times can produce a morbid change. Accordingly as the smallest vaccinal quantity of rat's leprous bacilli which can produce a morbid change without failure, we are used to vaccinate 0, 5 cc of the liquid which was made by diluting the original emulsion by 100 times

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In 1931 (the sixth of Showa) the author examined the 700 cases of lepers more than sixteen years old including both sexes (lepra tuberosa _??_ 312, _??_ 88, sum 400; Lepra nervosa _??_ 192, _??_108, sum 300.) taken in the Kyushu Lepra House to investigate the lost tooth, the state of eruption of the wisdom tooth, and the carious tooth, and came to a general conclusion as follows :-
(1) Percent number of teeth.
(a) Single person of the Lepers more than sixteen year old has 28.15 in average number ; in Lepra tuberosa 28.90, in Lepra nervosa 27.14. Namely the average number of teeth for a person in Lepra tuberosa is greater than in lepra nervosa by 1.76.
(b) The difference of number of tooth between upper and lower jaw or between left and right, is not so great.
(c) Regarding to the sex the male is always supreior to the female in the number of teeth. This fact coincides with the cases of a normal man. This difference betweem them increases with the lapse of time, and reaches to the extremity in their thirties where the difference is 6.19.
(2) Lost teeth.
(a) The lost teeth of the leper are a little more than those of the normal man.
(b) The average numbr of lost teeth for a leper is 29.7-3.7 in lepra tuberosa, 4.66 in lepra nervosa. Thus the lost teeth are remarkably numerous in lepra nervosa, and moreover in any age we find the majority of the lost teeth in lepra nervosa.
(c) Since thirty years or thereabouts the number of the lost teeth gradually increases with the lapse of time. In the old age more than sixty years 18.5 teeth for a lepra are lost on the average.
(d) Regarding to the sex, the lost tooth in the female is more numerous than in the male.
(e) Regarding to the kind of teeth we find the greatest number of the lost teeth in the molar teeth of the lower jaw ; and next the molar teeth of the upper jaw, and the premolar teeth of the lower jaw, the incisor teeth of upper jaw follow in orderThe smallest number of the lost tooth was found in the incisor of the lower jaw.
(f) There is no special difference between the state of the lost teeth according to their position, that is quite similar to the case of a normal man, and there is also no part where the teeth are lost especially earlier in the lepers.
(3) The state of eruption of wisdom teeth.
(a) Examining the 481 cases of lepers in their twenties and thirties, a wisdom tooth was found in 75.89 %, of which 45.11 % have 4 wisdom teeth.
The eruption-rate against all number of teeth is 62.05 % The average number of the wisdom teeth for a person is 2.48.
(b) The eruption-rate of wisdom teeth of the leper is seemed to be a little lower than the normal man and especially that is the case in the lepra nervosa.
(c) The eruption of wisdom teeth in lepra tuberosa is 64.50 %; and in lepra nervosa 57.9 %. Thus the eruption of wisdom teeth is more often hindered in the lepra nervosa than in the lepra tuberora.
(d) It is interesting that the eruption-rate in lepra nervosa is lower than in lepra tuberosa. Though it seems to be true to me that, the lower eruption-rate or th delay of eruption of wisdom tooth is caused by an invasion of nervous system of the lepra nervossa, it must be determined by the future studies.
(e) Regarding to the sex, the eruption-rate in the male is greater than in the female. It is similar to the case of a normal man.
(f) The eruption-rate of wisdom teeth of the upper jaw is gseater than that of the lower jaw.
(g) There is no significant difference between right and left.
(4) The morbidity of carious teeth.
(a) The morbidity of carious teeth among all the lepers is 61.75-64.0 % in lepra tuberosa, 66.33 % in lepra nervosa. Namely the morbidity in the cases of lepra nervosa is higher and its difference is 4.41 %. Moreover in any age, the morbidity in the cases of lepra nervosa is higher and esp scially in their thirties the difference is exatreme.

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In der letzten Nummer dieser Zeitschrift veroffentlichte Verf. eine Mitteilung uber die Dichtheit der spontanen Rattenlepra in einigen nord-ostlichen Prafekturen Japans (17 kranke Tiere unter 2157 untersuchten Haus- and Wanderratten), uber 12 Kulturen von uaurefesten Bacillen, die er von diesen Lepraratten gewonnen hatte and die er fur Mycobacterium leprae murium hielt, ferner uber die Impfresultatc mit diesen Kulturen an einer grosseren Reihe von Laboratoriumtieren, besonders an weissen Ratten.
In dieser neuer japanischen Abhandlung stellt Verf. nun die histologischen Ver-anderungen der angeschwollenen Lymphdrusen, der Hautlasionen und der sonstigen Ein-geweide von solchen Versuchstieren eingehend dar und vergleicht sie mit denjenigen, die er bei den Ratten mit spontaner Lepra sowie bei den durch Inokulation naturlicher Rattenlepramaterialien lepros infizierten welssen Ratten beobachtete.
Pathologische Prozesse liessen sick hierbei am starksten in den Lymphdrusen, zuweilen i n der Haut, nur selten in der Milz nachweisen. Die sonstigen Eingeweide waen gewohnlich frei von spezifischen pathologischen Veranderungen. Die Eigenschaft soldier Veranderungen, die hauptsachlich aus mehr oder weniger verbreiteten Haufen grosser Monocyten (sog. Leprazelleu) mit reichlichem Bacillengehalt bestehen, stimmen bei all die en drei Serien von Lepratieren im grossen und ganzen miteinander uberein. Soweit dennoch Unterschiede bestehen, so nur dem Grade und nicht der Beschaffenheit nach. Diese Tatsache ist ebenfalls ein Beweis dafur, dass Verf. die von ihm kultivierten saurefesten Bacillenstamme mit Recht mit Mycobacterium leprae murium identifizierte. Eire eingehendere Mitteilung in einer europaischen Sprache wird bei anderer Gelegenheit erscheinen

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