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Volume 36 (1967)
- Issue 4 Pages 199-
- Issue 3 Pages 137-
- Issue 2 Pages 63-
- Issue 1 Pages 1-
Volume 36, Issue 4
Displaying 1-8 of 8 articles from this issue
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SHIGENORI ISHIHARA1967 Volume 36 Issue 4 Pages 199-206
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESS1) The recent occurrence of four cases of bulbar palsy in leprosy reported. These are male patients, two of them are lepromatous and the others are tuberculoid and borderline leprosy.
2) At the beginning of the bulbar palsy the patients complained of headache, pain in the occipital region and the neck, toothache without caries, and double vision.
3) The patients showed difficulty in speech, swallowing, and mastication. Paralysis of the soft palate and facial palsy were also seen. Disturbance of the taste, marked salivation, increasing the anesthesia on the faces were recognized.
4) The patients were treated mainly with cortisone, Vitamine B12, B1, and aspiration pneumonia were prevented by antibiotics.
5) The patients have been improving progressively and have continued to fed well with the exception of one patient who complains of the salivation.
6) The causes of these bulbar palsy in leprosy are not detectable but the symptoms may be supposed to be a leprosy reaction.View full abstractDownload PDF (949K) -
(2nd Report) Effects of proteolytic enzymes on serum protein of patients with leprosyAKIRA MAYAMA1967 Volume 36 Issue 4 Pages 207-211
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSHydrolytic actions of various proteases (animal-pepsin, trypsin; vegetable- ananase, ficin, papain; bacterial and fungal-pronase, prozyme) on serum protein fractions in leprosy were determined by microelectrophoresis. In most cases of lepromatous leprosy, especially in those with erythema nodosum leprosum the digestion of serum proteins by proteases was more remarkable strong than in those with tuber- culoid leprosy and in healthy persons. It has been observed that proteolytic activities of trypsin and prozyme were stronger than those of any other proteases, and the hydrolytic activity became more pronounced by the cross addition of other proteases to serum proteins previously hydrolyzed with trypsin and prozyme. In lepromatous leprosy, the a2-macroglobulin and hemopexin were very easily digested by the enzymes. The haptoglobin, ceruloplasmin, transferrin and immunoglobulins, however, still re- mained moderately high after the treatment. The quantity of the antitrypsin and acid glycoprotein decreased slightly by proteolysis. However, even the immuno- globulins and antitrypsin were demonstrated to be strongly hydrolyzed by the proteases in all cases with erythema nodosum leprosum.View full abstractDownload PDF (621K) -
(II) Course after Treatment, Including the Shift in Immunological Activity MethodHIROSHI HOKIBARA1967 Volume 36 Issue 4 Pages 212-217
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSA total of 67 cases of leprosy, resistant to therapeutic agents heretofore available, were treated by various method over a period of one year and a definite shift in the condition from p to r, and an improvement in 86.5% of the skin eruptions were found and 30 of the cases became bacteria-negative. All 9 cases treated by homo- geneous, healthy skin grafts (including 2 cases of follow-up test) showed improvement in the skin eruptions and a trend for reduction in the rate of isolation of bacillus was observed. The delay in rejection of the skin grafts is believed to be due to the depressed immunological activity in leprosy. Though various problems, such as the effect of repeated skin grafts as revealed by the lepromin reaction, still must be clarified, it is considered that a shift in immunological action takes place by this method. The results suggest that not only chemotherapy but also treatment of the host should be studied in the future. In the treatment of leprosy, detailed investigation of prior therapy is required, especially in old cases and though individual differences are great arise in therapeutic effect may be anticipated by close cooperation between the patient and the doctor. This will be further accelerated by measures, such as shift in immu- nological activity, in the host. At the present stage, it is felt that the term, therapy resistant leprosy; is not entirely acceptable.View full abstractDownload PDF (569K) -
IWAO ARAKAWA1967 Volume 36 Issue 4 Pages 218-224
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSThere are various methods for the reconstruction of alopecia leprosa of the eyebrow and among them, eyebrow plasty with single-hair-transplant, by which the form of the brow and the hair stream can be controlled, appears to be most satisfactory. The method is not popular, however, because of the complexity and inefficiency. In the eyebrow, a convergent stream is produced by a upward hair stream and a downward hair stream. The shape of the eyebrow can be classified into several types according to the intensity of the accent of the superior edge of the eyebrow and the axis shape with the convergent stream as the axis. By planning the order of im- plantation of hair with the axis as the base, the shape of the brow and the hair stream can be readily and accurately produced. The hair-transplant must be carefully prepared without damaging the hair-follicle and-bulb and then carefully embedded. For this purpose, the use of cold physiological saline is advantageous: softening of the hair is prevented so that optimal hardness is maintained, making manipulation easy. In this way, a regular plan of procedure has been set up concerning (1) prepara- tion of the hair-transplant (2) method of implantation (3) design of the eyebrow shape (4) order of implantation. With this procedure, the defects of eyebrow-plasty with single-hair-transplant can not only be overcome but the advantages further enhanced, and by chosely following it, satisfactory results have been obtained.View full abstractDownload PDF (868K) -
Part 3. Effect of some drugs on multiplication of M. Leprae in mouse foot-PadsYOSHIYASU MATSUO1967 Volume 36 Issue 4 Pages 225-231
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSMycobacterium leprae was obtained from a relapsed patient with lepromatous leprosy under treatment with 5, 200mg of Ciba 1906 for the first 13 weeks and there- after with 3, 100mg of DDS for 2 months. The number of acid-fast bacteria was counted by the microspot method. CFA#1 mice were inoculated with 5.2×103M. leprae in the left hind foot-pad. The drug treatment was commenced 53 days and continued up to 266 days after inoculation. Sulfone (dihydrazinodiphenyl sulfone) and isoniazid were given 1mg orally and Ciba 1906 and streptomycin 4mg intra- gluteally at a time. The drug administration was carried out 6 times a week for the first 5 weeks, and thereafter 3 times a week. Harvests were made at the 176th, 220th, and 266th day of inoculation. Two to three mice from each group were killed, and the inoculated foot-pads pooled for each harvest. Multiplication of M. leprae in the untreated controls proceeded as expected. Sulfone gave almost complete and con- tinuous suppression of multiplication. Ciba 1906 was found to be as effective as sulfone until 220 days after inoculation, but was less effective later. Streptomycin suppressed multiplication moderately during the early stage of multiplication, and thereafter reduced the number of bacteria as effectively as sulfone. Isoniazid did not suppress multiplication in the early stage, but later prevented further bacillary increase.View full abstractDownload PDF (776K) -
Part 4. Effect of Vaccination on Multiplication of M. Leprae in Mouse Foot-PadsYOSXLYASU MATSUO1967 Volume 36 Issue 4 Pages 232-237
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSThree groups of CF#1 mice were vaccinated intramuscularly at the back 42 days before challenge of Mycobacterium leprae, and an additional 3 groups 48 days after challenge. The another one was the unvaccinated controls. All the mice were inoculated with (4.2×0.2)×103 M. leprae into the left hind foot-pads. When the vaccines were given before challenge, living BCG (1 mg/wet weight, 6.8×107viable units) was the most effective one and provided a continuing suppression of multipli- cation of M. leprae in the mouse foot-pads. Heat-killed vaccine of M. lepraemurium (the Kurume-42 strain, 7.3×107) also provided a continuous suppression, but less so than BCG. Vaccination with heat killed M. tuberculosis (H37Rv, 2 mg/wet weight) delayed multiplication but did not produce a continuing type of suppression. When the vaccines were given after challenge, BCG was the sole effective agent, but far less so than when given before challenge.View full abstractDownload PDF (637K) -
MASAO ISIKAWA1967 Volume 36 Issue 4 Pages 238-241
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSPutrescine is always observed in the blood of the lepromatous leprosy patient in whose skin M. leprae are found, but not observed in the blood of the lepromatous or tuberculoid leprosy patient in whose skin no M. leprae are found. Consequently, putrescine is considered to be one of the metabolites of M. leprae.View full abstractDownload PDF (227K) -
MASAO ISHIKAWA1967 Volume 36 Issue 4 Pages 242-245
Published: December 30, 1967
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSPromine reacts with glutamine promptly in vitro, but when promine is injected intravenously promine does not react with glutamine readily in human blood.View full abstractDownload PDF (232K)
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