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Volume 26 (1957)
- Issue 6 Pages 297-
- Issue 5 Pages 227-
- Issue 3 Pages 117-
- Issue 2 Pages 49-
- Issue 1 Pages 1-
Volume 26, Issue 2
Displaying 1-9 of 9 articles from this issue
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Korehiro TAKEDA1957 Volume 26 Issue 2 Pages 49-55
Published: March 20, 1957
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSIt is easily presumable, from the results of our studies on skin functions, that functions of endocrine and autonome nerve system participate in skin functions.
In previous studies, the characteristic skin functions of leprosy patients were attributed to the instability of individuality of patients, and to the functions of endocrine and autonome nerve system. This time, experiments were carried out to investigate the accommodating function of the skin in leprosy patients.
1) The average age of the first menstruation is delayed in leprosy patients by one year, especially in lepromatous patients and before manifestation of the symptoms.
2) The decrease of hypophysis-interbrain functions is remarkable and instability of the autonome nerve system (4/10) is observed. Epinephrin tests was abnormal in 57 of 67.
3) Agitation of neutrophile and eosinophile cells by administration of hormons or autonome toxins is recognized, but change of lymphocytes is slight. In some cases parasympathic toxin provoked urobilinogen in urine.
As the above results, instability of endocrine-autonome nerve system is observed in leprosy patients. Therefore, the accommodating functions are easily broken, prepating for the development of the disease.View full abstractDownload PDF (430K) -
Korehiro TAKEDA1957 Volume 26 Issue 2 Pages 56-65
Published: March 20, 1957
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSIn healthy people HSR presented different values according to the individuals, sexes, seasons and ages, while in various diseases it is characteristic, especially in leprosy it shows an extraordinary distribution. This fact tells the anticipation of endocrine-autonome nerve system. The following results were obtained from the experiments to examine the influences of endocrine-autonome nerve system upon HSR.
1) Injection and transplantation of ox hypophysis inhibits in general HSR of skin patients, as well as of leprosy patients, while in the cases of combined diseases HSR was promoted.
2) After operation HSR was inhibited in the early stage, but then it recovered.
3) ACTH and cortisone inhibited HSR.
4) In leprosy patients one administration of ovahormone, chiragen and ACE inhibited, while enarmone, prehormone and insulin increased HSR. As for autonome nerve toxins, the results were not decided.View full abstractDownload PDF (646K) -
RELATION BETWEEN THE SERIAL DILUTION OF LEPROMIN AND LESSENING OF REACTION INTENSITYKen YANAGISAWA, Michiaki MAEDA, Shigenori ISHIWARA, Osamu HATA, Jiro I ...1957 Volume 26 Issue 2 Pages 66-69
Published: March 20, 1957
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSEmploying 1687 leprosy patients, a study was made on the relation between dilution of lepromin and the change of reaction intensity, comparing 1:2, 1:4, and 1:8 dilutions with the original Mitsuda or the Dharmendra antigen. It was clarified that reaction intensity lessened with the increase of antigen dilution regardless of the type of antigen and of the type of reaction (the early or the late reaction).View full abstractDownload PDF (213K) -
Ken YANAGISAWA, Nozomu ASAMI, Shigerori ISHIWARA1957 Volume 26 Issue 2 Pages 70-76
Published: March 20, 1957
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSLepromin allergy was pursued after BCG vaccination regarding it as an indirect expression of leprous immunity. The results obtained in two separate populations of school children showed clearly the fact that BCG vaccination could convert more than half of the total objects to positive to lepromin test made 8 to 11 weeks after vaccination. For instance, in the first case where the vaccination was made by the scarification method, the positive conversion rate was 56.5 per cent in 11 weeks, and in the second case of intracutaneous vaccination it was 77.4 per cent in 8 weeks. In addition, it was found that a high correlation is kept between the lepromin reaction and the tuberculin reaction in connection with size of redness. The two populations of children employed for the present study is now undergoing the further survey of both kinds of allergy.
As far as the present study is concerned, the authors consider that BCG vaccination is effective for the prophylaxis of leprosy.View full abstractDownload PDF (398K) -
EFFECTS OF THE CHEMOTHERAPEUTIC AND NONCHEMOTHERAPEUTIC AGENTS UPON MURINE LEPROSY APPLYING NISHIMURA-IWASA'S SCREENING METHODShinji NISHIMURA, Taro MASUDA1957 Volume 26 Issue 2 Pages 77-81
Published: March 20, 1957
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe effects of the drugs mentioned in the Table 1 and 2 upon murine leprosy were examined, applying Nishimura-Iwasa's method, and the results obtained are summarized in Figure 1 and 2.
Isonicotinoyl-3-methoxy-4-hydroxybenzal hydrazone and Isonicotinyl-glucuronolactone-hydrazone are in large dosis slightly superior to INAH. Nsonicotinyl-N'-carbethoxy-hydrazine Hydrochloride and 2-(γ-pydidyl)-1.3.4 oxydiazolone-(5) have weaker inhibition than INAH. Proethyl, Tibione and Viomycin, an antibiotic have no effect upon murine leprosy.
Among nonchemotherapeutic agents, Triton (WR-1339) and Neominophagen AT have weak inhibitory effect, while Taifumin, Vitamin D2, Cepharanthin and Chiyugen have no effect.
Application of Nishimura-Iwasa's screening method enables us to examine and judge the effects of chemotherapeutic agents in three months. With nonchemotherapeutic agents the results were not in accordance with those obtained from our former experiments conducted in five months with rats. To know the possibility of screening test with mice of such nonchemotherapeutic agents in short period further experiments should be demanded.View full abstractDownload PDF (324K) -
SUPPLEMENTARY EXPERIMENTS ON OGATA'S SLIDE AGGLUTINATION METHOD AND COMPLEMENT BINDING REACTIONKikuo MINAMI1957 Volume 26 Issue 2 Pages 82-91
Published: March 20, 1957
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSOgata reported that the agglutination titer with the antigen of cardiolipin: lecithin =l: 1 was higher than that with the antigen of cardiolipin: lecithin =1: 10. In my supplementary experiments 64 % was positive, among which tuberous leprosy was positive in 75 %. 9 % of syphilitic and 12 % of other sera were positive, but the agglutination titers were low in all cases. The positivity of this reaction, combined with the clinical symptoms, leads us to the diagnosis of leprosy. The slide method with the antigen of cardiolipin: lecithin: cholesterol =1: 34: 30 and =1: 1: 18 presented the strong reaction, but not superior to the agglutination. Complement combining reaction with the antigen of cardiolipin: lecithin: cholesterol =1: 1: 20 reacted intensely in syphilis, but inferior to the agglutination. This reaction presented no specific result to murine leprosy.View full abstractDownload PDF (1250K) -
Katsuhito TAKIGAWA1957 Volume 26 Issue 2 Pages 92-96
Published: March 20, 1957
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSStatistical observations of 1, 232 leprosy patients reported from Jan, 1, 1953 to Dec. 31, 1955 present the following facts.
1) The ratio of male to female is 1.7-2.3: 1. In low ages there is no difference.
2) The age of manifestation shifted higher. And the frequency is most remarkable in 30-44 years.
3) Most of the patients belong to maculoneural type.
4) The occurence is more remarkable in the agricultural districts than in the urban districts.
5) The warmer districts, such as the Shikoku, Kyushu, Tokai and Kinki Districts are noticeable.
6) In lower ages of reported patients, 63-91% of them were admitted to the settlements, but in higher ages the percentages decreased.
7) The periods from leprosy diagnosis to admission were very short for most patients.View full abstractDownload PDF (324K) -
[in Japanese]1957 Volume 26 Issue 2 Pages 97-100
Published: March 20, 1957
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSDownload PDF (328K) -
[in Japanese], [in Japanese], [in Japanese]1957 Volume 26 Issue 2 Pages 101-108
Published: March 20, 1957
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSDownload PDF (1003K)
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