All issues
Volume 22 (1969)
- Issue 6 Pages 411-
- Issue 5 Pages 349-
- Issue 4 Pages 269-
- Issue 3 Pages 197-
- Issue 2 Pages 139-
- Issue 1 Pages 1-
Predecessor
Volume 22, Issue 4
Displaying 1-11 of 11 articles from this issue
- |<
- <
- 1
- >
- >|
-
SHOZO NAKAZAWA, HISAKO ONO, TAKESHI NISHINO, HARUHIDE KAWABE, SACHIIKO ...1969 Volume 22 Issue 4 Pages 269-275
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSIn the bacteriological studies on cephalexin, the following results were obtained.
1. Both gram-positive and gram-negative bacteria were almost equally sensitive to cephalexin. This result appeared to differ from those of cephalothin and cephaloridine which were more sensitive to gram-positive than to gram-negative bacteria.
2. The sensitivities of the clinical isolates of Staph. aureue (64 strains) and E. coli (41 strains) were almost same as those of standard strains, though some strains of E. coli were observed to be resistant to cephalexin.
3. Antibacterial activity of cephalexin in vitro was not influenced by pH of medium and serum, though it was increased to some extent at pH5. Inoculum size had some influence on the antibacterial activity.
4. Cephalexin showed bactericidal action to Staph. aureus and E. coli at the concentrations of more than 3.5mcg/ml and 12.5mcg/ml.
5. The stability in solution, artincial development of resistance,inactivation by β-lactamase and in vivo activity in experimental infections in mice were also studied.View full abstractDownload PDF (3673K) -
1969 Volume 22 Issue 4 Pages 275-275,286
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSDownload PDF (2038K) -
SHOZO NAKAZAWA, MASAMITSU ISHIYAMA, MASAKO OHTSUKI, KEIJI KAKITA, KEIK ...1969 Volume 22 Issue 4 Pages 276-286
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
TADAKAZU SUYAMA, YOSHIGORO OGURO, TAKUJI DOI, KEN-ICHI IZAKA1969 Volume 22 Issue 4 Pages 287-298
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAntibacterial action of human placental lysozyme alone or in combination with penicillins was studied in vitro and in vivo experiments.
In vitro experimentals, the lysozyme was found to inhibit the growth of Bacillus subtilis at the concentration of 30mcg/ml of medium, but not to inhibit the growth of Clostridium tetani, Staphylococcus aureus or Diplococcus pneumoniae even at the concentration of 1,000mcg/ml of medium. These inhibitory activities of placental lysozyme were comparable to those of egg white lysozyme. Combined antibacterial effect of the lysozyme with penicillins was noticed in S. aureus and D. pneumoniae, but in C. tetani.
In vivo studies, however, preliminary administration of placental lysozyme alone or in combination with penicillin G exerted a marked prolongation on survival time of mice infected by C. tetani Harvard, suggesting a protective effect against tetanus infections, although the lysozyme preparation did not show any antitoxin action both in vitro and in vivo experiments. In order to control the experimental tetanus infection in mice with lysozyme it seemed necessary to inject intramuscularly daily dose of 50 to 100mcg/mouse for 7 days (3 doses before and 4 doses after infection). Staphylococcal infection in mice was also protected by intramuscular administration of the lysozyme alone. This effect was potentiated by combined use with penicillins. In case of pneumococcal infection the lysozyme alone did not show significant prolongation on survival time of mice, but it potentiated the protective effect of penicillins against this experimental infections.View full abstractDownload PDF (1872K) -
TOYOKO OGURI, NOZOMU KOSAKAI1969 Volume 22 Issue 4 Pages 299-302
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
KYOKO TANABE, YASUKO AMANO, MICHIYO YAMASAKI, TOSHIKO SAKAMOTO, KENJIR ...1969 Volume 22 Issue 4 Pages 303-307
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
KENKICHI KAWAMATA1969 Volume 22 Issue 4 Pages 308-310
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
FUSANOSUKE YAMASAKU, RYO TSUCHIDA, OKUHIRO ARAI, MASASHI YAMAZAKI, KOH ...1969 Volume 22 Issue 4 Pages 311-314
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
KAZUYUKI SAKAGUCHI, TAKASHI MIZUKAWA1969 Volume 22 Issue 4 Pages 315-316
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
YOSHIAKI KUMAMOTO, TAKAHIRO TAMIYA, KEIJI TAKATSUKA1969 Volume 22 Issue 4 Pages 317-318
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
Effect of penicillin derivatives on Escherichia coliJUN IGARI, YUKINORI KUNISADA, KAORU KOIKE1969 Volume 22 Issue 4 Pages 319-322
Published: August 25, 1969
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
- |<
- <
- 1
- >
- >|