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Volume 25, Issue 1
Displaying 1-8 of 8 articles from this issue
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NOBUHIKO KOMATSU, HIROAKI IEHARA, NOBORU NAGUMO1972 Volume 25 Issue 1 Pages 1-5
Published: February 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAn extracellular polysaccharide, designated as schizophyllan, from Schizophyllum commune exhibits the host-mediated antitumor effect on subcutaneously transplanted tumors, such as Sarcoma 37, Sarcoma 180 and Ehrlich carcinoma. In order to know the influence of schizophyllan therapy on the inhibition of cell migration in tumor-bearing mice, the migration inhibition test, which is considered to be closely related to the establishment of cellular immunity, has been carried out, using peritoneal cells of mice transplanted subcutaneously with Sarcoma 37 cells.
Nearly no inhibition of cell migration was observed in the presence of antigen (sonicates of Sarcoma 37 cells) in the following groups of mice:(1) normal,(2) normal, treated with schizophyllan only, and (3) immunized with killed tumor cells.
On the contrary,the macrophage migration was inhibited in the presence of antigen in the following groups of mice:(1) tumor-bearing,(2) regressed after treatment with schizophyllan, and (3) non-regr-essed by the treatment. The degree of inhibition proved to be most remarkable in the peritoneal cells from the regressed mice by the treatment with schizophyllan.View full abstractDownload PDF (3679K) -
1972 Volume 25 Issue 1 Pages 5-5,16
Published: February 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSDownload PDF (581K) -
RINZO SOEJIMA, HARUO NOZUTE, KATSUMASA TOKUNAGA, YUKIO SETO, JIRO KANA ...1972 Volume 25 Issue 1 Pages 6-8
Published: February 25, 1972
Released on J-STAGE: May 17, 2013
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YUTAKA KANAZAWA, TOSHIO KURAMATA1972 Volume 25 Issue 1 Pages 9-16
Published: February 25, 1972
Released on J-STAGE: May 17, 2013
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KAZUFUTO FUKAYA1972 Volume 25 Issue 1 Pages 17-20
Published: February 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS1. The change of number of Candida in stool was observed during intermittent administration of Amphotericin B (AMPH) to mice for 40 days.
The sensitivity test to AMPH of Candida isolated in above experiments showed no development of resistance.
2. The standard curve for bioassay of AMPH was drawn by both vertical superposing and cup plate method using Candida albicans. As the detectable lower limit was relatively high, the bioassay was considered to be insufficient for practical use.
3. The protein binding rate of AMPH examined by cellophane bag dialysis using horse serum was calculated to be 43% on an average.
4. The adsorption rate to sheep red blood cells was as high as 3.30.
5. All of organ levels following AMPH intramuscular injection in dose of 2 mg to a mouse were below detectable level.
6. The reduction of activity of AMPH was moderate when mixed with each organ homogenate of mice.View full abstractDownload PDF (495K) -
SHOZO NAKAZAWA, HISAKO ONO, GO WAJIMA, TAKETOSHI IZAWA1972 Volume 25 Issue 1 Pages 21-27
Published: February 25, 1972
Released on J-STAGE: May 17, 2013
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Primary clinical trial by oral administrationKANJI SEIGA, MASAO MINAKAWA, KATSUHIKO MIYOSHI, KUNIHIKO YAMAJI, YOKO ...1972 Volume 25 Issue 1 Pages 28-30
Published: February 25, 1972
Released on J-STAGE: May 17, 2013
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1972 Volume 25 Issue 1 Pages 60-
Published: 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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